“…28 When administered at a dosage of 50 mg/kg (IV or PO) every 6 hours in rabbits 5 and dogs, 4 dipyrone is also effective in the treatment of postoperative pain; in situations of mild and moderate pain, the drug can be used alone at a dose of 50 mg/kg, thereby avoiding the adverse effects associated with opioid administration completely. 4,29 A systematic review 30 of the clinical efficacy of a single dose of dipyrone (500 mg) in the treatment of postoperative pain in humans revealed that dipyrone administered IM had a superior analgesic effect to that of pethidine (100 mg), ketorolac (30 mg), or morphine (10 mg) administered IM. 4 In such a scenario, dipyrone is not only opioid sparing but can also improve analgesia and potentially reduce the adverse effects of opioids.…”