Postoperative respiratory difficulty due to asymptomatic anterior cervical osteophyte after brain tumor surgery: a case report

Shin, Hye Won; Jang, Joon Chul; Lim, Hyong Hwan; Park, Min Kyung; Bae, Go Eun; Choi, Sung Uk; Park, Ji Yong

doi:10.4097/kjae.2016.69.6.640

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…The spontaneous self‐assembly of P NDI in four different aqueous mixtures was investigated using fluorescence and CD spectroscopy (Figure ). P NDI was equilibrated for ≥30 min in pure water at a pH of about 5.5 (designated as W) or at pH 7.0 (W pH=7 ), or in water mixtures with co‐solvents that promote hydrogen bonding (water/acetonitrile 3:2; W/A) or decrease the likelihood of monomers interaction via hydrogen bonds (water/hexafluoro‐2‐propanol (HFIP) 4:1; W/H) . The fluorescence spectra of the self‐assembled compounds show three emission peaks (Figure a), one at 415 nm that is attributed to monomeric NDI emission, and two others at 485 nm and 530 nm, indicative of excimer formation due to π‐stacking interactions .…”

Section: Figurementioning

confidence: 99%

“…Self‐assembly in the W or W/A solutions is mostly governed by hydrogen bonding and electrostatic interactions, favoring β‐sheet formation and leading to long fibrils, similar to those observed for KFE‐8 (Supporting Information, Figure S6). Indeed, assembly in acetonitrile–water mixtures has been previously shown to drive fast fibril growth while inhibiting the formation of bundled architectures . In the polar W/H solution, HFIP creates a layer around the peptide molecules reducing the accessibility of the backbone hydrogen bonds to interact with other monomers .…”

Section: Figurementioning

confidence: 99%

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The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils

et al. 2016

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Peptide fibril nanostructures have been advocated as components of future biotechnology and nanotechnology devices. However, the ability to exploit the fibril functionality for applications, such as catalysis or electron transfer, depends on the formation of well‐defined architectures. Fibrils made of peptides substituted with aromatic groups are described presenting efficient electron delocalization. Peptide self‐assembly under various conditions produced polymorphic fibril products presenting distinctly different conductivities. This process is driven by a collective set of hydrogen bonding, electrostatic, and π‐stacking interactions, and as a result it can be directed towards formation of a distinct polymorph by using the medium to enhance specific interactions rather than the others. This method facilitates the detailed characterization of different polymorphs, and allows specific conditions to be established that lead to the polymorph with the highest conductivity.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils

et al. 2016

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“…Egerter et al [7] noted significant improvement six months after surgery was completed. This range of variability could be related to age, comorbidities, location of osteophyte, thickness of osteophyte, complexity of the surgery, or postoperative edema [21,22], which in turn makes prognostication difficult.…”

Section: Introduction and Literature Reviewmentioning

confidence: 99%

Impact of Osteophytectomy on Swallowing Function in a Patient with Chronic Dysphagia

Howard¹,

Phillips²,

Henley³

et al. 2020

obm geriatr

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Anterior cervical osteophytes are common in the geriatric population. Dysphagia can occur in individuals suffering from these spinal abnormalities. Surgical intervention is an uncommon course of treatment for these patients, but is often utilized as a last resort with the hope of swallow recovery. The purpose of this article is to highlight a unique case study documenting the required treatment course for dysphagia associated with osteophytes and subsequent osteophytectomy. We review current literature of both conservative and surgical interventions, as well as discuss the rehabilitation course for a complex patient with persistent dysphagia. Various outcome measures were utilized during the patient’s inpatient stay to track progress including the Functional Oral Intake Scale (FOIS), the Bolus Residue Scale (BRS), Penetration Aspiration Scale (PenAsp), Dysphagia Outcome Severity Scale (DOSS), and a Modified Barium Swallow Study (MBSS). The patient received rehabilitative training including oral motor and pharyngeal strengthening exercises, respiratory strengthening, speech instruction, cognitive retraining, and instrumental assessment. Following osteophytectomy and dysphagia rehabilitation the patient did not show any change based on a repeat MBSS which revealed the necessity for the patient to remain nothing per oral (NPO). The patient demonstrated an inability to manage his secretions, requiring continual suctioning. Upon discharge the patient remained NPO with the exception of ice chips, utilized a PEG for nutrition, and had a red capped tracheostomy. He was on room air and independently utilized oral suction as needed for secretion management. Our patient’s clinical course was not aligned with typical osteophytectomy recovery as progress after his 25-day inpatient stay was limited. The goal of this case study is to contribute information to the limited and variable data available regarding treatment options, outcome measures and timelines for recovery as it pertains to patients who undergo an osteophytectomy.

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Postoperative respiratory difficulty due to asymptomatic anterior cervical osteophyte after brain tumor surgery: a case report

Cited by 2 publications

References 14 publications

The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils

The Strong Influence of Structure Polymorphism on the Conductivity of Peptide Fibrils

Impact of Osteophytectomy on Swallowing Function in a Patient with Chronic Dysphagia

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