Postoperative recurrence and risk factors of colorectal cancer perforation

Asano, Hiroshi; Kojima, Kazuto; Ogino, Naomi; Fukano, Hiroyuki; Ohara, Yasuhiro; Shinozuka, Nozomi

doi:10.1007/s00384-016-2694-3

Cited by 47 publications

(35 citation statements)

References 20 publications

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“…Intestinal perforation at the time of diagnosis is not a significant risk factor for relapse, as our study shows, against to other studies in the literature (6,(25)(26)(27)(28). The risk of relapse is 2 times greater for patients with perforation compared to nonperforated cases, and is higher in the first 30 months post-op, eventually the survival curves getting close to each other, being almost similar at 60 months post-op.…”

Section: Discussioncontrasting

confidence: 52%

Prognostic Factors Analysis for Colon Cancer with Lymph Node Negative

Vilcea¹,

Romain²,

Rohr³

et al. 2018

chr

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We performed a retrospective analysis regarding the impact of prognosis factors for patients with high recurrence risk in stages I and II. We studied 99 patients with T2, T3 and T4 tumors who suffered a curative resection and whom may or may not present indication for adjuvant chemotherapy according to histoprognostic factors and molecular biomarkers. We performed a univariate Cox regression which highlighted that male sex is a risk factor for disease relapse (HR=5.53, p 0.05, IC95% = 1.29 to 23.73). Although with a low statistical significance effect, T4 tumors seems to be associated with a poor prognosis regarding disease relapse (HR = 2.56, p = 0.06, IC95% = 0.94 to 6.99) compared to T2 and T3 tumors. Patients with d'MMR (MSI-H) seem to have a more favorable evolution compared to patients with p'MMR (MSS/MSI-L) - HR (d'MMR vs p'MMR) = 0.19, IC95% = 0.02 to 1.61, p = 0.13. We believe that it would be useful for MSS / MSI to be systematically analyzed, our data suggesting a better response of d`MMR patients to adjuvant chemotherapy. The multivariate Cox regression did not identify independent risk factors of relapse.

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Section: Discussioncontrasting

confidence: 52%

Prognostic Factors Analysis for Colon Cancer with Lymph Node Negative

Vilcea¹,

Romain²,

Rohr³

et al. 2018

chr

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“…The biggest drawback of local resection is its failure to dissect the lymph nodes in relevant drainage areas. Left metastatic lymph nodes are an important reason for postoperative recurrence, which is also the reason why caution should be taken if local resection is selected[ 34 - 36 ]. Consequently, if it is not clear whether preoperative lymph node metastasis is present in T1-stage CRC, radical surgery may be the most suitable choice.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Sun

Zhou

et al. 2017

WJG

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AIMTo explore the features and prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer (CRC).METHODSIn all, 321 cases of T1-stage CRC were selected from 10132 patients with CRC who received surgical therapy in six large-scale hospitals in China and were retrospectively analyzed. Univariate and multivariate analyses were performed to analyze the risk factors for lymphatic metastasis. A survival analysis was then performed to analyze the prognostic value of lymph node metastasis.RESULTSThe occurrence rate of T1 stage was 3.17% (321/10132); of these patients, the lymph node metastasis rate was 8.41% (27/321), and the non-lymph node metastasis rate was 91.59% (294/321). Univariate analysis showed that preoperative serum CEA, preoperative serum CA199, preoperative serum CA724, vascular invasion, and degree of differentiation were associated with lymph node metastasis in T1-stage CRC (P < 0.05 for all). Multivariate analysis indicated that preoperative serum CA724, vascular invasion, and degree of differentiation were closely related to lymph node metastasis (P < 0.05 for all). Log-rank survival analysis showed that age, preoperative serum CEA, preoperative serum CA199, vascular invasion, degree of differentiation, and lymph node metastasis (χ2 = 24.180, P < 0.001) were predictors of 5-year overall survival (OS) (P < 0.05 for all). COX regression analysis demonstrated that preoperative serum CA199 and lymph node metastasis (HR = 5.117; P < 0.05; 95%CI: 0.058-0.815) were independent prognostic indicators of 5-year OS in patients with T1-stage CRC (P < 0.05 for both).CONCLUSIONThe morbidity of T1-stage CRC was 3.17% for all CRC cases. Preoperative serum CA724, vascular invasion, and degree of differentiation are independent risk factors for lymph node metastasis. Lymph node metastasis is an independent prognostic factor for OS in patients with T1-stage CRC.

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“…However, the mechanism underlying the development of colorectal cancer is largely unclear, which poses great difficulty in designing treatments and improving prognosis (35). despite an abundance of basic and clinical research conducted on colorectal cancer, the diagnosis and treatment of the disease remains within the scope of surgical chemotherapy and radiotherapy, the recurrence rate after surgery is high (36). Therefore, it is of great importance to discover novel colorectal cancer treatment targets and more effective treatment strategies.…”

Section: Ccnd1 Is Required For the Proliferation And Apoptosis Of Ht-mentioning

confidence: 99%

MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels

Guo

Xue

2020

Mol Med Report

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Microrna (mir)-628-5p serves as an antitumor gene in a variety of cancers; however, the role of mir-628-5p in colorectal cancer remains largely unclear. The purpose of this study was to investigate the role and mechanism of mir-628-5p in colorectal cancer. reverse transcription-quantitative Pcr (RT-qPCR), colony formation assays and flow cytometric analysis were used to determine the expression levels of mir-628-5p in colorectal cancer tissues and cell lines, and the proliferative ability of colorectal cancer cells. TargetScan version 7.2 and dual-luciferase reporter assay were performed to predict and confirm mir-628-5p target genes. The expression levels of cyclin d1 (ccnd1) and related genes were determined using rT-qPcr or/and western blotting analysis. mir-628-5p mimics and ccnd1 plasmids were used to overexpress mir-628-5p and ccnd1; it was demonstrated that the expression levels of miR-628-5p were significantly downregulated in colorectal cancer tissues and cell lines. mir-628-5p mimic-transfected cells inhibited the proliferation and induced apoptosis of HT-29 cells. ccnd1, a downstream effector of mir-628-5p, promoted the proliferation and suppressed apoptosis of HT-29 cells, and the effects were reversed by mir-628-5p mimics. in conclusion, the present study suggested that colorectal cancer progression may be regulated through the mir-628-5p/ccnd1 axis, and mir-628-5p could be used as a potential diagnostic and prognostic biomarker for colorectal cancer.

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Postoperative recurrence and risk factors of colorectal cancer perforation

Cited by 47 publications

References 20 publications

Prognostic Factors Analysis for Colon Cancer with Lymph Node Negative

Prognostic Factors Analysis for Colon Cancer with Lymph Node Negative

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels

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