Postoperative Ratio of C-Reactive Protein to Albumin as a Predictive Marker in Patients with Crohn’s Disease Undergoing Bowel Resection

Abstract

Background. The ratio of C-reactive protein (CRP) to albumin (CAR) has a significant correlation with postoperative complications and acts as a predictor in patients with pancreatic cancer and colorectal cancer. However, whether the CAR can be used to predict complications in Crohn’s disease (CD) patients after surgery has not yet been reported. Methods. A total of 534 CD patients undergoing surgery between 2016 and 2020 were enrolled. The risk factors of postoperative complications were assessed by univariate and multivariate analyses. The cutoff values and the accuracy of diagnosis for the CAR and postoperative CRP levels were examined with receiver operating characteristic (ROC) curves. Results. The rate of postoperative complications was 32.2%. The postoperative CAR (OR 13.200; 95% CI 6.501-26.803; P < 0.001 ) was a significant independent risk factor for complications. Compared with the CRP level on postoperative day 3, the CAR more accurately indicated postoperative complications in CD patients (AUC: 0.699 vs. 0.771; Youden index: 0.361 vs. 0.599). ROC curves showed that the cutoff value for the CAR was 3.25. Patients with a CAR ≥ 3.25 had more complications ( P < 0.001 ), a longer postoperative stay ( 15.5 ± 0.6 d vs. 9.0 ± 0.2 d, P < 0.001 ), and more surgical site infections (48.2% vs. 5.7%, P < 0.001 ) than those with a CAR < 3.25 . Conclusions. Compared to the CRP level, the CAR can more accurately predict postoperative complications and can act as a predictive marker in CD patients after surgery.

Association between the High-Sensitivity C-Reactive Protein/Albumin Ratio and New-Onset Chronic Kidney Disease in Chinese Individuals

“…The high-sensitivity CRP (hs-CRP)/albumin ratio (CAR) is a novel inflammatory index that has been widely used in the study of inflammation-related diseases. An elevated CAR has previously been shown to be positively associated with Crohn’s disease [ 12 ], COVID-19 infection [ 13 ], acute pancreatitis [ 14 ], oral squamous cell carcinoma [ 15 ], ovarian malignancies [ 16 ], non-small cell lung cancer [ 17 ], nasopharyngeal tumors [ 18 ], and coronary heart disease [ 19 , 20 ]. The CAR has also been identified as a prognostic marker of infection, rheumatoid arthritis, and critical illness [ 21 – 23 ] and is strongly linked with kidney disease.…”