Postoperative radiotherapy to stabilize a tumor embolus in clear cell renal cell carcinoma: A case report

Gong, Zhihua; Yan, Lv-Jun; Sun, Jianping

doi:10.3892/ol.2014.2421

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Renal cell carcinoma has been considered a radio-resistant malignancy [18,[20][21][22]. Indeed, conventional radiotherapy (2 Gy per fraction) causes only a limited cytotoxic effect.…”

Section: Discussionmentioning

confidence: 99%

Hypofractionated radiotherapy for renal cell carcinoma with inferior vena cava tumour thrombus

Bełdzińska¹,

Gądek²,

Rutkowski³

2022

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Renal cell carcinoma (RCC) constitutes about 3% of all malignant neoplasms in adults. Clear cell carcinoma is the most frequent type, accounting for about 65% of cases. It tends to invade the veins and form tumour thrombi in inferior vena cava (IVC-TT), occasionally reaching the right atrium. Nephrectomy and thrombectomy are standard therapeutic procedures performed in RCC-IVC-TT. Despite proven effectiveness of surgery, this entity in IVC-TT is associated with poor outcome. The role of palliative radiotherapy in this entity is undetermined. We present a case of a 43-year-old female patient after right-sided nephrectomy due to advanced RCC which invaded the IVC, hepatic veins, and right atrium. The patient has been treated with postoperative, hypofractionated radiotherapy on the residual disease.

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“…Renal cell carcinoma has been considered a radio-resistant malignancy [18,[20][21][22]. Indeed, conventional radiotherapy (2 Gy per fraction) causes only a limited cytotoxic effect.…”

Section: Discussionmentioning

confidence: 99%

Hypofractionated radiotherapy for renal cell carcinoma with inferior vena cava tumour thrombus

Bełdzińska¹,

Gądek²,

Rutkowski³

2022

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“…There have been only two reports of radiotherapy for IVC tumor thrombosis of RCC. One is a case report of intensity-modulated radiotherapy (56 Gy/24 fractions of one fraction per day) that stabilized a tumor embolus in clear cell RCC [7]. Another is the only existing report of SRT for IVC tumor thrombus of RCC by Hannan et al, which showed only partial remission at two years follow-up and 18-month survival [8].…”

Section: Discussionmentioning

confidence: 99%

Giant Tumor in the Inferior Vena Cava Treated With CyberKnife

Harada

Miyazaki²,

Kunimura

2021

Cureus

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Renal cell carcinoma (RCC) is a slow-progressing cancer that may cause tumor embolism in the inferior vena cava (IVC) and has a high mortality rate. Treatment for IVC metastasis of RCC is basically surgical resection often requiring cardiopulmonary bypass. RCC has been regarded as a radio-resistant tumor; however, stereotactic radiotherapy (SRT) has proven effective in recent years. We present a case of advanced RCC in which CyberKnife radiotherapy was successful in saving and preserving quality of life. An 81-year-old male presented with severe edema in both legs. Contrast CT scan displayed giant tumor in IVC and bilateral mediastinal lymphadenopathy. The cancer appeared to originate from the lower pole of the right kidney. The tumor protruded into the right atrium, and surgical resection with pump oxygenator was impossible due to patient's age. CyberKnife SRT was performed for tumor in the IVC. Biopsy for hilar lymph node revealed clear cell RCC, and the second CyberKnife treatment was performed. The patient is surviving over three years without any symptoms. CyberKnife was successful in preserving patient's quality of life for advanced stage IV RCC.

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“…This may include a combination of surgery, chemotherapy, and radiation. Interventional approaches include placement of an intravascular stent or surgical bypass grafting [ 5 ]. The patient was noted to have significant improvement in her lower extremity edema after initiation of capecitabine and oxaliplatin, likely resulting in reduction in the size of the metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…An underlying cancer is the cause of more than 90% of cases of the SVC syndrome. Other cancers associated with SVC syndrome include thymoma, mesothelioma, lymphoma, and germ cell tumors [ 5 ]. However, the clinical presentation of these malignancies does not include vena cava compression in most cases.…”

Section: Introductionmentioning

confidence: 99%

The inferior vena cava (IVC) syndrome as the initial manifestation of newly diagnosed gastric adenocarcinoma: a case report

Patel

2015

J Med Case Reports

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IntroductionVena cava compression is a relatively rare initial manifestation of underlying malignancy. The superior vena cava syndrome, which is characterized by facial plethora, jugular venous distension, and arm swelling, is a well-known entity associated with bronchogenic carcinoma. Less common is the compression of the inferior vena cava. To the best of my knowledge, this is the first reported case of newly diagnosed gastric adenocarcinoma presenting initially as the inferior vena cava syndrome. The unique aspect about this case is that it highlights a rare presentation before diagnosis of gastric adenocarcinoma.Case presentationA 56-year-old Malaysian woman with a past medical history of iron deficiency anemia presented with lower extremity edema and progressive fatigue of 1 month’s duration. She had significant worsening of leg swelling after standing for short periods of time. She also reported epigastric discomfort, which led to an additional workup, including computed tomography of the abdomen and pelvis. This revealed a 3cm×2.9cm mass in the stomach, extensive hepatic metastasis, and severe inferior vena cava compression. The patient was examined further with esophagogastroduodenoscopy, and a biopsy showed gastric adenocarcinoma.ConclusionsThis report describes a case of a patient with inferior vena cava syndrome as a unique presentation of previously undiagnosed stage IV gastric adenocarcinoma. Patients presenting with inferior vena cava syndrome should undergo prompt evaluation for underlying malignancies that have a predilection for hepatic metastasis. This case is important because earlier recognition of this syndrome can lead to earlier workup and thus detection of malignancy. Prompt initiation of treatment, including chemotherapy or vena cava stent placement, can result in improved patient outcome.

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Postoperative radiotherapy to stabilize a tumor embolus in clear cell renal cell carcinoma: A case report

Cited by 3 publications

References 11 publications

Hypofractionated radiotherapy for renal cell carcinoma with inferior vena cava tumour thrombus

Hypofractionated radiotherapy for renal cell carcinoma with inferior vena cava tumour thrombus

Giant Tumor in the Inferior Vena Cava Treated With CyberKnife

The inferior vena cava (IVC) syndrome as the initial manifestation of newly diagnosed gastric adenocarcinoma: a case report

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