Postoperative radiotherapy for cutaneous melanoma of the head and neck region

Ang, K. Kian; Peters, Lester J.; Weber, Randal S.; Morrison, William H.; Frankenthaler, Robert A.; Garden, Adam S.; Goepfert, Helmuth; Ha, Chul S.; Byers, Robert M.

doi:10.1016/0360-3016(94)90351-4

Cited by 184 publications

(105 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our overall rerecurrence rate of 28% in patients who did not receive adjuvant radiation is similar to the figure reported by O'Brien et al (O'Brien et al, 1997) and lower than many reports (O'brien et al, 1997). The dramatic decrease in recurrence in our patient both with N3 disease and regional disease overall is in agreement with the findings of Ang and colleagues (Ang et al, 1994) from the MD Anderson unit in Texas. Ang and colleagues (Ang et al, 1994) were able to demonstrate a dramatic reduction in recurrence when neck dissection was followed with adjuvant radiation compared with historic control data where surgery alone was used.…”

Section: Wwwintechopencomsupporting

confidence: 92%

“…The dramatic decrease in recurrence in our patient both with N3 disease and regional disease overall is in agreement with the findings of Ang and colleagues (Ang et al, 1994) from the MD Anderson unit in Texas. Ang and colleagues (Ang et al, 1994) were able to demonstrate a dramatic reduction in recurrence when neck dissection was followed with adjuvant radiation compared with historic control data where surgery alone was used. Incidently they were also able to demonstrate that adjuvant radiation also reduction in recurrence following excision of prognostically unfavourable primary melanomas.…”

Section: Wwwintechopencomsupporting

confidence: 92%

See 1 more Smart Citation

Management of Head and Neck Melanoma

Shaw¹,

Fay²

2011

Treatment of Metastatic Melanoma

View full text Add to dashboard Cite

Section: Wwwintechopencomsupporting

confidence: 92%

Section: Wwwintechopencomsupporting

confidence: 92%

Management of Head and Neck Melanoma

Shaw¹,

Fay²

2011

Treatment of Metastatic Melanoma

View full text Add to dashboard Cite

“…Detailed studies performed by Overgaard (17) demonstrated that hypofractionated doses of RT are the most effective. This finding has been supported by other clinical studies (20)(21)(22)(23).…”

Section: Introductionsupporting

confidence: 87%

Radiotherapy-induced decreases in substance P levels may potentiate melanoma growth

Erin¹

2009

Mol Med Rep

View full text Add to dashboard Cite

Abstract. Substance P, a member of the tachykinin family, is expressed in primary invasive malignant melanomas, metastatic melanomas, melanomas in situ, atypical naevi, and spindle and epithelioid cell naevi. The role of substance P in cancer development and progression is not clear. Radiotherapy, which is used extensively in the treatment of malignancies, alters substance P levels. It is, however, not known whether radiotherapy affects substance P levels in melanomas or in the tumor microenvironment. Given the fact that melanomas express substance P, possible radiation-induced changes in substance P content may underlie their radio-resistance. Hence, the aim of the present study was to determine the effects of radiotherapy on the growth of B16F10 melanomas as well as on the tumor and systemic expression of substance P. In vivo exposure of tumor-bearing C5BL/6 mice to ionizing radiation (45 Gy administered in three fractions) arrested tumor growth for three weeks and induced 3-fold increases in survival, as well as decreasing substance P levels in primary tumors and the surrounding skin. Although radiotherapy was applied locally (1 x 1 cm) at the mid-flank region of the animal, it also induced systemic changes in the levels of substance P. Specifically, radiotherapy decreased substance P levels in skin distant from the radiation field as well as in the lungs and adrenals. In order to understand the significance of this effect, B16F10 cells and cells made from metastatic lesions (B16LNAD cells) were treated with substance P. Substance P inhibited the growth of B16F10 and B16LNAD cells and further potentiated the inhibitory effects of radiotherapy. These findings demonstrate for the first time that substance P inhibits melanoma growth, and that radiotherapy-induced decreases in substance P levels may underlie the radio-resistance of melanomas.

show abstract

“…Moreover, this regimen has been extensively studied in patients with high risk melanoma, with 5-year local-regional control rates approaching 90%. The reported incidence of late toxicity with this regimen is very low, including in patients with tumors of the axilla and supraclavicular fossa [18,19].…”

Section: Discussionmentioning

confidence: 99%