Postoperative Perfluoro-N-Octane Tamponade for Primary Retinal Detachment Repair

Abstract

Perfluoro-n-octane is efficacious and safe as a short-term vitreous substitute in primary rhegmatogenous retinal detachment repair cases with inferior/multiple breaks or GRTs. Perfluoro-n-octane removal within 10 days reduces its side effect profile considerably. The highest anatomical retinal reattachment rates were observed when C3F8 or silicone oil was exchanged for PFO.

Pars Plana Vitrectomy With Medium-Term Postoperative Perfluoro-N-Octane for Recurrent Inferior Retinal Detachment Complicated by Advanced Proliferative Vitreoretinopathy

“…15,28 We observed a high rate (32%) of a characteristic inflammation compared with some previous clinical studies using postoperative PFO for RD. [22][23][24] This may be because of the longer average duration of PFO used in the present study, or underrecognition and retrospective design of previous studies. Rush et al 22 have recently observed inflammation with posterior lens capsule deposits in a comparable proportion (8/39) of eyes with postoperative PFO and reported similar resolution after PFO removal and clinical management with topical corticosteroids.…”

“…[22][23][24] This may be because of the longer average duration of PFO used in the present study, or underrecognition and retrospective design of previous studies. Rush et al 22 have recently observed inflammation with posterior lens capsule deposits in a comparable proportion (8/39) of eyes with postoperative PFO and reported similar resolution after PFO removal and clinical management with topical corticosteroids. Despite the frequent observation of vitreous cavity inflammation with indwelling PFO, we did not observe a statistically significant relationship between this response and visual or anatomical outcome.…”

“…Intraocular pressure elevation is a well-described phenomenon in the context of silicone oil, 30 but it has been ill-defined regarding PFO as a vitreous substitute. Some previous retrospective series [22][23][24]26 involving a similar technique have reported no or lower incidence. Rush et al 22 recently reported IOP elevation in 36% of eyes treated with postoperative PFO that was associated with macroscopically detectable PFO in the anterior chamber, identical to our report.…”

“…Previous reports have indicated mixed results using heavier-than-water compounds, and previous series investigating PFO 11,[22][23][24]27 have reported small samples of patients with PVR. The results of the present study indicate that a high rate of anatomical success can be achieved with short duration postoperative PFO in advanced PVR.…”

“…Recently, several reports have indicated that PFO may be left in the vitreous cavity postoperatively for short durations and may be useful for inferior retinal tamponade. [22][23][24] The purpose of the present study was to describe a technique involving PPV, intermediate (2-to 3-week duration) "medium-term" postoperative PFO (MT-PFO) followed by staged PFO removal in patients presenting with inferior retina redetachment complicated by Grade C PVR.…”