Background: Post-operative care is necessary for good surgical outcomes. It requires vigilance and careful regular observation of the child. Counseling and educating mothers regarding the clefts and the various procedures are one of the most vital aspects of treatment. Aim: To evaluate the effect of the intervention program on awareness and practice of mothers regarding post-operative care of their children with cleft lip and cleft palate. Design: A quasi-experimental design (Pre & Post) was used.