Postoperative Pain Scores After Open Inguinal Hernia Repair: Comparison of Three Postoperative Analgesic Regimens

Mulita, Francesk; Parchas, Nikolaos; Solou, Konstantina; Tchabashvili, Levan; Gatomati, Foteini; Iliopoulos, Fotios; Maroulis, Ioannis

doi:10.5455/medarh.2020.74.355-358

Cited by 21 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies investigating the analgesic effect of combined pethidine/paracetamol and parecoxib/ paracetamol have not been published so far in patients undergoing thyroidectomy. Studies comparing the analgesic efficacy of paracetamol monotherapy vs. paracetamol combinations with either pethidine or parecoxib in patients undergoing laparoscopic cholecystectomy and open inguinal hernia repair have found the same results as our study [29,30]. One limitation of this study that should be considered is that we did not record data during mobilization, because pain scores were recorded only at rest.…”

Section: Discussionsupporting

confidence: 55%

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Mulita¹,

Verras²,

Iliopoulos³

et al. 2021

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 55%

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Mulita¹,

Verras²,

Iliopoulos³

et al. 2021

Self Cite

View full text Add to dashboard Cite

“…Another strategy that was investigated by Mulita et al studied the use of intravenous (IV) acetaminophen with intramuscular (IM) pethidine, acetaminophen with IV parecoxib, and acetaminophen monotherapy. It was shown that combinations of IV acetaminophen with either IM pethidine or IV parecoxib were superior to IV acetaminophen monotherapy in patients undergoing open inguinal hernia repair and laparoscopic cholecystectomy [ 13 , 14 ]. This drug regimen provides another potentially efficacious modality to treat post-operative pain.…”

Section: Discussionmentioning

confidence: 99%

Surgeon's Impact on Opioid Epidemic Following Uncomplicated Laparoscopic Appendectomy and Cholecystectomy

Trivedi¹,

Yang²,

Barbash³

et al. 2022

Cureus

View full text Add to dashboard Cite

The opioid crisis in the United States remains a major issue that is directly linked to the prescribing practices of physicians. There is a lack of consistency in post-operative prescribing of narcotic medications. We have designed a retrospective study to evaluate factors that contribute to the prescription of opioids following common laparoscopic procedures. In this study, we analyzed peri-operative medications and pain requirements and how they relate to the frequency in which narcotics are prescribed at Saint Joseph’s University Medical Center (SJUMC), a level two trauma center and teaching hospital. We also studied how the frequency of narcotic prescriptions is related to patient demographics and surgeon practices. We propose that standardizing pain medication protocols will be an effective way to decrease overall narcotic use as well as prescriptions for common laparoscopic procedures.

show abstract

“…Also, one of the major patient concerns undergoing inguinal hernia repair is postoperative pain and the need to return to work and daily activity as soon as possible [ 17 ]. The goal of postoperative pain management is to reduce or eliminate pain and discomfort with the least side effects and minimal cost.…”

Section: Discussionmentioning

confidence: 99%

Intrathecal Co-administration of Morphine Facilitated the Anti-nociceptive of Bupivacaine in a Rat Model of Acute Postoperative Pain

Ghosh¹,

Ray²

2022

Cureus

View full text Add to dashboard Cite

Introduction: Bupivacaine is one of the commonly used agents for spinal anaesthesia. Moreover, co-administration with morphine can likely increase its anti-nociceptive effect bringing about a reduction in the required dose of bupivacaine. Though this has been observed clinically, preclinical studies on the efficacy of this drug combination are lacking. Methods: Sprague Dawley rats, previously implanted with intrathecal catheters, were administered either bupivacaine (30 mcg) or morphine (30 mcg) or both bupivacaine and morphine (15 mcg each). These doses were determined following prior evaluation of different doses of bupivacaine (3, 10 and 30 mcg). Rats were subjected to hind paw incision under isoflurane anaesthesia, 15 min after drug administration. Anti-nociception was evaluated by estimating mechanical allodynia in a fixed peri-incisional area using von Frey filaments. This was done 4 h after the incision. Results: Both bupivacaine and morphine attenuated allodynia though morphine was more effective. Co-administration of both drugs at half the doses increased the antinociceptive effect of bupivacaine to the 30 mcg dose level. Conclusion: The underlying reason for this enhanced anti-nociception could be the different neural mechanisms responsible for anti-nociception. Local anaesthetics inhibit the generation of action potentials by blocking sodium channels whereas opioids like morphine act through G-protein coupled mu opioid receptor-linked closure of calcium channels in presynaptic terminals. In conclusion, the addition of morphine can facilitate bupivacaine’s anti-nociceptive effect following intrathecal administration. This information could have clinical relevance in the treatment of postoperative pain.

show abstract

Postoperative Pain Scores After Open Inguinal Hernia Repair: Comparison of Three Postoperative Analgesic Regimens

Cited by 21 publications

References 21 publications

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy

Surgeon's Impact on Opioid Epidemic Following Uncomplicated Laparoscopic Appendectomy and Cholecystectomy

Intrathecal Co-administration of Morphine Facilitated the Anti-nociceptive of Bupivacaine in a Rat Model of Acute Postoperative Pain

Contact Info

Product

Resources

About