Postoperative neutrophil-to-lymphocyte ratio variation is associated with chronic subdural hematoma recurrence

Oliveira, Adilson de; Solla, Davi Jorge Fontoura; Oliveira, Klever F de; Amaral, Bruno S; Andrade, Almir Ferreira de; Kolias, Angelos; Paiva, Wellingson Silva

doi:10.1007/s10072-021-05241-y

Cited by 12 publications

(15 citation statements)

References 30 publications

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“…[22][23][24][25] A retrospective study found that postoperative neutrophil count and NLR were higher in those who recurred, and postoperative NLR ratio was independently associated with recurrence. 26 In this study, we found both NLR and PLR of the CSDH patients were higher than those of healthy controls but lower than the upper limit of normal reference values indicated in the literature. 27 After the hematoma was absorbed and cured, these markers, which were significantly higher than those of blood routine in healthy controls, were also basically returned to normal.…”

Section: Discussionsupporting

confidence: 39%

“…Neutrophil‐lymphocyte count ratio and PLR are important indicators of the inflammatory responses, and these two indicators have been applied as diagnostic criteria in many inflammatory responses and immune diseases 22–25 . A retrospective study found that postoperative neutrophil count and NLR were higher in those who recurred, and postoperative NLR ratio was independently associated with recurrence 26 . In this study, we found both NLR and PLR of the CSDH patients were higher than those of healthy controls but lower than the upper limit of normal reference values indicated in the literature 27 .…”

Section: Discussionmentioning

confidence: 99%

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The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients

Fan

Zhang

et al. 2022

Clinical Laboratory Analysis

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Chronic subdural hematoma (CSDH), characterized by pathological hematocele, is a common disease in neurosurgery. Its total incidence has reached 13.5-58.1/100,000 per year, and it is increasingly common in the elderly. 1,2 The Japan Neurosurgical Database showed that operation for CSDH is the most common neurosurgical management in 2018 and 2019(19.4-18.9%). 3 However, approximately 10-20% of surgically treated patients experience postoperative recurrence necessitating reoperation 4 which brings enormous economic, physical and mental burdens to patients.

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Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients

Fan

Zhang

et al. 2022

Clinical Laboratory Analysis

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“…In addition, patients with low RPR improved more in terms of Karnofsky performance status at 3 months [18]. The third study, a retrospective cohort study on 160 patients, indicated that a postoperative neutrophil-to-lymphocyte ratio (NLR) ≥ 1 (i.e., NLR that remains high compared to its preoperative value) and the postoperative absolute neutrophil counts were independently associated with recurrence [19].…”

Section: Biofluids and Biomarker Typesmentioning

confidence: 98%

“…The median (interquartile range, IQR) patient sample size of the included studies was 93 (60-258). The median (IQR) recurrence rate of twenty-one studies (two studies did not provide recurrence data) was 17.5% (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Study and Population Characteristicsmentioning

confidence: 99%

Biofluid Biomarkers in the Prognosis of Chronic Subdural Hematoma: A Systematic Scoping Review

Georgountzos,

Gkalonakis,

Anastasopoulos

et al. 2023

Diagnostics

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The present systematic scoping review aimed at mapping and analyzing the available literature on biological fluid (biofluid) biomarkers showing promise in the prediction of chronic subdural hematoma (cSDH) recurrence and the prognosis of neurological/functional patient outcome. Twenty-three studies published between 2003 and 2023 investigating a diverse range of biomarkers in hematoma fluid and/or the circulation in 3749 patients were included. Immune cell populations and inflammatory/anti-inflammatory cytokines comprised the most studied category of biomarkers displaying significant findings. A notable time trend in biomarker studies was a recent shift in research focus towards the analysis of circulating biomarkers. Several biomarkers were indicated as independent predictors of cSDH recurrence and/or functional/neurological outcome, including circulating fibrinogen degradation products (FDP), brain natriuretic peptide (BNP-1) and high-density lipoprotein (HDL), as well as blood urea nitrogen (BUN) and the ratios of blood neutrophil to lymphocyte (NLR) or red blood cell distribution width to platelet count (RPR). While studies on cSDH prognostic biomarkers have gained, in recent years, momentum, additional multicenter prospective studies are warranted to confirm and extend their findings. The identification of prognostic biofluid biomarkers in cSDH is an active field of research that may provide future tools, guiding clinical decisions and allowing for the design of treatments based on risk stratification.

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“…Like other inflammatory diseases, inflammatory cells are initially part of the healing process, but exacerbation and/or perpetuation turn it into a pathologic process, turning it into pathological processes. 27 The study by Fan et al found that CSDH only caused a mild inflammatory response, suggesting that not all components of the hematoma flowed into the peripheral blood. 16 In the study of an acute subdural hemorrhage (SDH) model, Fan et al demonstrated that hematomas in the subdural space drain extracranially through the meningeal and cervical lymphatics.…”

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confidence: 99%

A Linear Regression Equation for Predicting the Residual Volume of Chronic Subdural Hematoma 1 Week After Surgery

Yan,

Su,

et al. 2023

NDT

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The outcome of chronic subdural hematoma (CSDH) is influenced not only by the choice of treatment but also by various baseline characteristics. The main objective of this study is to identify the risk factors that can affect the prognosis of CSDH and develop a regression equation based on these risk factors. Methods: A total of 212 patients with CSDH were included in the study. We collected clinical data including age, gender, and so on, and radiological data including preoperative hematoma volume (V 1 ), effusion volume 1 day after surgery (V 2 ), gas volume 1 day after surgery (V 3 ), and so on. These were considered independent variables, while residual volume 1 week after surgery (V 4 ) was the dependent variable. Univariate linear regression analysis was performed to identify factors that were significantly related. Subsequently, multivariate linear regression analysis was conducted to determine the relationship between each independent variable and the dependent variable. Multiple linear regression analysis was used to obtain a regression equation predicting V 4 . Results: We have found that age (t = 3.109, P = 0.002), aspirin (t = 2.762, P = 0.006), hemostatic agents (haemocoagulase, t = 3.731, P < 0.001; vitamin K, t = 2.824, P = 0.005 < 0.05), V 2 (t = 8.73, P < 0.001), and V 3 (t = 5.968, P < 0.001) are significantly associated with V 4 . Furthermore, we have developed a regression equation that can predict this volume with CSDH. The fit of the model is robust with an R-squared value of 65.2% > 50%. Conclusion: Age, aspirin, hemostatic agent, V 2 , and V 3 are significantly associated with V 4. We developed a regression equation to predict this volume with CSDH.

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Postoperative neutrophil-to-lymphocyte ratio variation is associated with chronic subdural hematoma recurrence

Cited by 12 publications

References 30 publications

The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients

The inflammatory cellular feature in the peripheral blood of chronic subdural hematoma patients

Biofluid Biomarkers in the Prognosis of Chronic Subdural Hematoma: A Systematic Scoping Review

A Linear Regression Equation for Predicting the Residual Volume of Chronic Subdural Hematoma 1 Week After Surgery

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