Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the german prospective randomized trial hit ’91

Kortmann, Rolf Dieter; Kühl, Joachim; Timmermann, Beate; Mittler, U; Urban, Christian; Budach, Volker; Richter, Eckart; Willich, Normann; Flentje, Michael; Berthold, Frank; Slavc, Irene; Wolff, Johannes; Meisner, Christoph; Wiestler, Otmar D.; Sörensen, Nils Arne; Warmuth‐Metz, Monika; Bamberg, M.

doi:10.1016/s0360-3016(99)00369-7

Cited by 385 publications

(258 citation statements)

References 33 publications

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“…It was also true in the cases of pediatric brain tumors [10]. However, prior cranial irradiation increased cisplatin ototoxicity in children and young adult patients [8,9,14,21]. With cisplatin alone, there is a negligible risk of hearing loss at doses of 90-360 mg/m 2 and this risk increases to 60 -80% when combined with prior irradiation.…”

Section: Discussionmentioning

confidence: 97%

Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma

Kim

Choi

et al. 2004

Radiotherapy and Oncology

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Section: Discussionmentioning

confidence: 97%

Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma

Kim

Choi

et al. 2004

Radiotherapy and Oncology

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“…Chemotherapy was routinely administered to all patients who were treated after 1995. The chemotherapy regimen comprises lomustine, cisplatin, and vincristine as published previously (2,16).…”

Section: Methodsmentioning

confidence: 99%

Microarray-Based Screening for Molecular Markers in Medulloblastoma Revealed STK15 as Independent Predictor for Survival

et al. 2004

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Medulloblastoma, a primitive neuroectodermal tumor of the cerebellum, is one of the most common central nervous system malignancies of childhood. Despite aggressive multimodal therapy, including surgery, irradiation, and chemotherapy, 5-year survival rates have only approached 50 -60%. To identify potential candidate genes that predict for overall survival (OS), we performed a gene expression profiling analysis in 35 newly diagnosed medulloblastoma neoplasms. Subsequently, the nine most promising candidate genes were analyzed by immunohistochemistry and fluorescence in situ hybridization on tumor tissue microarrays representing a series of 180 tumors. We found 54 genes in which expression levels predicted for unfavorable survival in medulloblastoma. In line with the gene expression profiling analysis, a positive staining for STK15 (P ‫؍‬ 0.0006), stathmin 1 (P ‫؍‬ 0.001), and cyclin D1 (P ‫؍‬ 0.03) was associated with an unfavorable OS, whereas cyclin B1, DAXX, Ki-67, MYC, NRAS, and p53 showed no statistical significant effect. In comparison to clinically defined parameters such as gender, age, metastatic stage, extent of tumor resection, application of chemotherapy, and tumor grade, positive staining for STK15 was identified as an independent prognostic factor for OS (P ‫؍‬ 0.026). Moreover, additional gene copy numbers of MYC (P ‫؍‬ 0.003) and STK15 (P ‫؍‬ 0.05) predicted for poor survival. The combination of gene expression profiling with tissue microarray experiments allowed the identification of a series of candidate genes that predicts for survival in medulloblastoma. Of the results highlighted by the various data analysis procedures, genes associated with cell proliferation (cyclin D1), transcription (MYC), and especially mitosis (stathmin 1, STK15) appear particularly intriguing with respect to medulloblastoma pathomechanism.

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“…Various multidrug chemotherapeutic regimens have been used (see Table 2). Chemotherapy is now a standard therapeutic method in patients with medulloblastoma due to the fact that maintenance chemotherapy after radiotherapy seems to deliver superior survival rates 9 . Chemotherapy was indicated in our patient, but radiotherapy was not administered because of patient's age.…”

Section: Discussionmentioning

confidence: 99%

Purely intramedullary spinal cord primitive neuroectodermal tumor: case report and review of the literature

et al. 2009

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Introduction. Primitive neuroectodermal tumors (PNETs) are malign neoplasms of the central nervous system which mainly locate in cerebellum (medulloblastoma). Primary intraspinal PNETs are rare. Within this group, we have found ten cases of purely intramedullary PNETs (IPNETs). In this report, we describe a new IPNET case and review the literature about these infrequent intramedullary tumors.Case report. A 17 month-old boy showed progressive decrease of motion in his lower extremities. Spine magnetic resonance imaging revealed an intramedullary expansive lesion from T3 to T10. A near-total removal was performed. The pathological diagnosis was PNET. Subsequent chemotherapy was recommended. Six months after operation, holocord progression has occurred.Conclusion. IPNETs are uncommon tumors affecting children and young adults. They are characterized by recurrence, progression or intracranial dissemination. Outcome is dismal: most patients die within two years in spite of surgical resection followed by radiotherapy and chemotherapy. Caso clínico. Se trata de un niño de 17 meses de edad que ha desarrollado una paraparesia progresiva. La resonancia magnética espinal muestra una lesión expansiva intramedular que se extiende desde T3 hasta T10. Se procedió a una extirpación macroscópica casi completa. El estudio anatomopatológico reveló un PNET. Se recomendó quimioterapia. Seis meses después de la cirugía, ha habido progresión a lo largo de la médula.Conclusión. Los PNETs exclusivamente intramedulares son raras neoplasias que afectan a niños y adultos jóvenes. Se caracterizan por la recurrencia, progresión o diseminación intracraneal. Son procesos de muy mal pronóstico, ya que los pacientes mueren en los primeros dos años a pesar de la resección quirúrgica y posterior radioterapia y quimioterapia.

show abstract

Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the german prospective randomized trial hit ’91

Cited by 385 publications

References 33 publications

Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma

Sensory neural hearing loss after concurrent cisplatin and radiation therapy for nasopharyngeal carcinoma

Microarray-Based Screening for Molecular Markers in Medulloblastoma Revealed STK15 as Independent Predictor for Survival

Purely intramedullary spinal cord primitive neuroectodermal tumor: case report and review of the literature

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