Postoperative Irradiation of Brain Ependymomas: Analysis of 33 cases

Marco, A. Di; Campostrini, Franco; Pradella, R.; Reggio, M; Palazzi, M.; Grandinetti, Antonella; Garusi, G. F.

doi:10.3109/02841868809093535

Cited by 23 publications

(12 citation statements)

References 18 publications

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“…Adult patients seem to have at least a trend for better prognosis than pediatric patients with a 5-year survival of 55-90% and of 14-60%, respectively [36,37,42,48,54]. Namely, the younger the child, the worse the prognosis [5,36,43,49]. It was suggested that pediatric ependymomas could behave more aggressively, based on the more immature neural tissue of the children [36,54].…”

Section: Prognostic Factorsmentioning

confidence: 98%

“…Postoperative magnetic resonance allows both a better evaluation of the degree of resection and the selection of cases with residual tumor in whom immediate second-look surgery could be useful. Significant improvements of neurosurgical techniques and neuroanesthesia allowed a reduction of operative mortality from 25-50% for infratentorial and from 6-22% for supratentorial ependymomas to <5% [36,43,48,52].…”

Section: Therapeutic Management Surgerymentioning

confidence: 99%

“…Myxopapillary ependymoma and subependymoma have a favorable prognosis, late recurrences and distant metastases being very uncommon. According to some authors tumor grade is the most important determinant of prognosis [5,33,34,[42][43][44][45], whereas others did not find any correlation between survival and histologic grade suggesting that the outcome is influenced by anatomical location, which influence resecability, rather than by pathological features [35,36,[46][47][48][49]. The 5-year survival for patients with low-grade tumors ranges 55-87%, whereas for anaplastic ependymomas it is 10-47% [33,37,43,50].…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…The rate of gross total resection in infratentorial tumors depends on their location, being up to 100% in the roof of the fourth ventricle, 86% in mid-floor tumors and 54% in the lateral recesses [48]. Spinal cord tumors, which in the majority of cases are low-grade lesions, can often be removed without functional sacrifice and completely in 27-45% of cases [32,33,42,43,45,[63][64][65].…”

Section: Therapeutic Management Surgerymentioning

confidence: 99%

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Current management and prognostic factors for adult ependymoma

Reni¹,

Brandes²

2002

Expert Review of Anticancer Therapy

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The optimum therapeutic management in adult ependymoma remains undefined because of the low incidence of this disease and because most of reported series mainly refers to childhood, are retrospective, include a small number of patients and span several decades. The purpose of this article is to analyze, discuss and summarize the current available information regarding the therapeutic approach and the prognostic factors and to provide recommendations for ordinary clinical practice. Some important therapeutic issues like the irradiation dose and volume are also analyzed. Finally, the main open questions as well as current and expected investigation trends are discussed.

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Section: Prognostic Factorsmentioning

confidence: 98%

Section: Therapeutic Management Surgerymentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

Section: Therapeutic Management Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Current management and prognostic factors for adult ependymoma

Reni¹,

Brandes²

2002

Expert Review of Anticancer Therapy

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“…There appears to be no outcome difference whether focal radiotherapy, whole brain radiation, or craniospinal radiation is used as far as survival is concerned [15][16][17], The long-term delete rious effect of extensive radiation therapy, particularly in the very young, cannot be overemphasized. The value of chemotherapy remains disputed, although a positive ef fect has been noted in anecdotal reports on recurrent cra nial ependymomas [ 18,19], C onclusion…”

Section: Discussionmentioning

confidence: 99%

Posterior Fossa Lateral Ependymoma in Childhood

Nagib¹,

O’Fallon²

1996

Pediatr Neurosurg

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Radiotherapy of primary malignant brain tumors

Larson

Wara

1998

Semin. Surg. Oncol.

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Radiotherapy is usually recommended for patients with a primary malignant brain tumor. The foundation for its use is grounded on the results of randomized trials for malignant gliomas which have demonstrated a relationship between survival and external beam radiation dose. Although similar trials have not been performed for most other primary intracranial tumors, radiation oncologists treat them in a similar fashion, delivering the highest possible dose consistent with acceptable levels of normal tissue damage. In most cases, focal therapy is required, using modern three‐dimensional treatment planning and delivery—with whole brain or craniospinal therapy used only for infrequently encountered clinical presentations. With modern planning, the volume of normal tissue subjected to possible radiation damage can be minimized. Radiation effects in normal tissues typically occur months to years after treatment. Semin. Surg. Oncol. 14:34–42, 1998. © 1998 Wiley‐Liss, Inc.

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Postoperative Irradiation of Brain Ependymomas: Analysis of 33 cases

Cited by 23 publications

References 18 publications

Current management and prognostic factors for adult ependymoma

Current management and prognostic factors for adult ependymoma

Posterior Fossa Lateral Ependymoma in Childhood

Radiotherapy of primary malignant brain tumors

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