Postoperative gastrectomy outcomes in octogenarians with gastric cancer

Mikami, Jota; Kurokawa, Yukinori; Miyazaki, Yasuhiro; Takahashi, Tsuyoshi; Yamasaki, Makoto; Miyata, Hiroshi; Nakajima, Kiyokazu; Takiguchi, Shuji; Mori, Masaki; Doki, Yuichiro

doi:10.1007/s00595-014-1087-x

Cited by 22 publications

(12 citation statements)

References 21 publications

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“…They found significantly more complications in the octogenarian group than in the younger age group (54.3% vs. 41.2%, respectively) [ 24 ]. Other studies also reported more complications among older aged patients compared to younger patients [ [25] , [26] , [27] , [28] ]. In the present study, we divided patients into the 3 following groups: adult (age 18–59 years), older adult (age 60–79 years), and octogenarian (age 80 years and over).…”

Section: Discussionmentioning

confidence: 88%

Factors associated with complication after gastrectomy for gastric or esophagogastric cancer compared among surgical purpose, surgical extent, and patient age: Retrospective study from a high volume center in Thailand

Parakonthun

Sirisut

Nampoolsuksan

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Discussionmentioning

confidence: 88%

Factors associated with complication after gastrectomy for gastric or esophagogastric cancer compared among surgical purpose, surgical extent, and patient age: Retrospective study from a high volume center in Thailand

Parakonthun

Sirisut

Nampoolsuksan

et al. 2022

Annals of Medicine &Amp; Surgery

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“…Mortality rates for elderly patients undergoing resection for gastric cancer vary considerably in the literature, ranging from 2% to 10.1% in Asian studies and 3% to 8% in European studies 17‐30 . This inconsistency is corroborated by US studies showing 30 days postoperative mortality rates specifically in octogenarians of 5%, 10.2%, and 7.2% using single‐institutional, multi‐institutional, and ACS‐NSQIP data respectively 31‐33 .…”

Section: Introductionmentioning

confidence: 99%

“…This inconsistency is corroborated by US studies showing 30 days postoperative mortality rates specifically in octogenarians of 5%, 10.2%, and 7.2% using single‐institutional, multi‐institutional, and ACS‐NSQIP data respectively 31‐33 . In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients 17‐24,26,27‐30,32,33 . Data are similarly conflicting with regards to the outcomes of elderly vs young patients with GE junction tumors undergoing esophagectomy 34‐36 .…”

Section: Introductionmentioning

confidence: 99%

“…Mortality rates for elderly patients undergoing resection for gastric cancer vary considerably in the literature, ranging from 2% to 10.1% in Asian studies and 3% to 8% in European studies. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] This inconsistency is corroborated by US studies showing 30 days postoperative mortality rates specifically in octogenarians of 5%, 10.2%, and 7.2% using single-institutional, multi-institutional, and ACS-NSQIP data respectively. [31][32][33] In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients.…”

mentioning

confidence: 99%

“…[31][32][33] In contrast, these studies have established mortality rates ranging from 0% to 4.1% in their younger patients, with conflicting data on whether or not survival differs between elderly and younger patients. [17][18][19][20][21][22][23][24]26,[27][28][29][30]32,33 Data are similarly conflicting with regards to the outcomes of elderly vs young patients with GE junction tumors undergoing esophagectomy. [34][35][36] This study aims to compare perioperative outcomes and survival of patients age 80 or older with younger patients undergoing curative resection for esophagogastric adenocarcinoma at our institution.…”

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confidence: 99%

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Perioperative outcomes and survival of octogenarians undergoing curative resection for esophagogastric adenocarcinoma

Chen

Senders

Hardacre

et al. 2020

Journal of Surgical Oncology

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Background and Objectives Current data are conflicting as to whether the outcomes of octogenarians undergoing resection for esophagogastric adenocarcinoma are comparable to younger patients. This study aims to compare perioperative outcomes and survival of patients ≥80 years old with younger patients undergoing curative resection for esophagogastric adenocarcinoma. Methods Retrospective data were collected on 190 patients who underwent resection with curative intent for adenocarcinomas found in the stomach and esophagogastric junction from 2004 to 2015 at a single institution. Results Of the 190 patients, 34 (18%) were ≥80 years old. Octogenarians were more likely to have chronic kidney disease (CKD) and were less likely to have received neoadjuvant chemotherapy. Pathologic features were similar between groups. Octogenarians' tumors were more likely to be located in the gastric body as compared to the esophagogastric junction in younger patients. Although the length of stay was comparable, octogenarians were significantly less likely to be discharged home (P < .01). Both groups had a single death during the index admission. Incidence and severity of 90 days postoperative complications were not significantly different between groups. There was no difference in 30‐day, 90‐day, 1‐year, or median survival. Conclusions Perioperative outcomes and survival of octogenarians undergoing curative resection for esophagogastric cancer are comparable to younger patients at our institution.

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Postoperative Long‐Term Outcomes in Elderly Patients with Gastric Cancer and Risk Factors for Death from Other Diseases

et al. 2019

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Background Elderly patients with gastric cancer are frequently treated surgically in current clinical practice. Although several studies have investigated short‐term outcomes after gastrectomy in elderly patients, most did not evaluate long‐term outcomes. Methods We analyzed 1154 consecutive patients who underwent curative gastrectomy for gastric cancer between 2001 and 2013. We classified them into two groups: the elderly group (n = 241), consisting of patients aged ≥75 years, and the non‐elderly group (n = 913), consisting of patients aged <75 years, and compared the short‐ and long‐term outcomes between the two groups. The risk factors for death from other diseases in elderly patients were also examined. Results Although the incidence of postoperative pneumonia was significantly higher in the elderly group (P < 0.001), the proportion of overall postoperative complications did not differ significantly between the two groups (P = 0.097). The disease‐specific survival was similar between the two groups (P = 0.743), whereas the overall survival in the elderly group was significantly shorter than that in the non‐elderly group (P < 0.001) because of a higher incidence of death from other diseases throughout all gastric cancer stages. Multivariate analysis revealed that a low preoperative prognostic nutrition index (PNI) and multiple comorbidities were significant risk factors for death from other diseases within 5 years in the elderly group. Conclusions Despite acceptable short‐term outcomes, long‐term outcomes in elderly patients with gastric cancer were poor due to the high incidence of death from other diseases. Indications for surgery in elderly patients with a low PNI or multiple comorbidities should be considered carefully.

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Postoperative gastrectomy outcomes in octogenarians with gastric cancer

Abstract: Octogenarian patients with gastric cancer experienced more complications than younger patients. Therefore, closer monitoring is needed for octogenarian patients who will receive total gastrectomy.

Cited by 22 publications

References 21 publications

Factors associated with complication after gastrectomy for gastric or esophagogastric cancer compared among surgical purpose, surgical extent, and patient age: Retrospective study from a high volume center in Thailand

Factors associated with complication after gastrectomy for gastric or esophagogastric cancer compared among surgical purpose, surgical extent, and patient age: Retrospective study from a high volume center in Thailand

Perioperative outcomes and survival of octogenarians undergoing curative resection for esophagogastric adenocarcinoma

Postoperative Long‐Term Outcomes in Elderly Patients with Gastric Cancer and Risk Factors for Death from Other Diseases

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