Postoperative Endophthalmitis

Kuriyan, Ajay E.; Hussain, Rehan M.; Flynn, Harry W.

doi:10.1007/978-3-030-42634-7_98

Cited by 1 publication

(1 citation statement)

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“…This corresponds to the histological findings of fungal elements close to the ciliary body epithelium and the posterior lens surface. The anteriorly located focus of infection may also have contributed to the relatively rapid and asymmetric nuclear cataract formation [ 35 ]. Owing to the slow and unilateral inflammation with vitreous involvement, fungal endophthalmitis was initially suspected.…”

Section: Discussionmentioning

confidence: 99%

Endogenous fungal endophthalmitis caused by Cladophialophora devriesii: report of a case and literature review

Krohn,

Power,

Mylvaganam

et al. 2024

J Ophthal Inflamm Infect

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Purpose To report a case of endogenous endophthalmitis caused by the dematiaceous fungus Cladophialophora devriesii. Methods Observational case report and literature review. Case presentation A 73-year-old female with a history of chronic obstructive pulmonary disease presented with a red and painful left eye. Examination revealed anterior segment inflammation and vitritis, indicative of endophthalmitis. She underwent core vitrectomy and intravitreal injection of vancomycin and amphotericin B. The vitreous sample showed inflammatory cells and fungal hyphae, and systemic amphotericin B and itraconazole were commenced for fungal endophthalmitis. Targeted amplification of the sample for bacterial DNA (V2-V3 region of 16 S rDNA) was negative, but fungal DNA targets (ITS1 and ITS2) were present, and their sequences were consistent with Cladophialophora devriesii. Phenotypic characterisation and sequencing of ITS1 and ITS2, carried out on cultured fungus from the sample, also revealed Cladophialophora devriesii. She received repeated intravitreal injections of voriconazole, and based on the antifungal susceptibility results, her systemic medication was changed to posaconazole. After 12 months, the eye showed no signs of inflammation, and posaconazole therapy was discontinued. After 3 months without antifungal medication, the inflammation recurred, and she was restarted on antifungal therapy for an additional 20 months. Another recurrence occurred 3 months after discontinuation of treatment, and a repeat vitreous sample confirmed the presence of Cladophialophora devriesii. She was started on isavuconazole, but developed seclusio pupillae and painful secondary glaucoma. Due to the duration and severity of the infection, the eye was enucleated. Histopathology revealed persistent fungal elements at the ciliary processes and the posterior lens surface. Conclusions This second reported case of endogenous endophthalmitis caused by Cladophialophora devriesii illustrates the role of vitreous sampling and molecular methods in diagnosis and treatment of fungal endophthalmitis. Despite early diagnosis and prolonged local and systemic antifungal therapy, it was not possible to achieve long-term control of the fungal infection.

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Section: Discussionmentioning

confidence: 99%