Postoperative Deep Venous Thrombosis After Renal Transplantation

Brunkwall, Jan; Bergqvist, David; Bergentz, Sven‐Erik; Bornmyr, S.; Husberg, B

doi:10.1097/00007890-198705000-00008

Cited by 40 publications

(21 citation statements)

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“…It has been used in kidney, liver, lung and intestines transplants, in the postoperative evaluation to check the presence of venous thrombosis (Brunkwall et al, 1987), acute rejection (Klar et al, 1999) and immunosupression drugs toxicity (Doutreleau et al, 2001).…”

Section: "The 20th Century Will Be Remembered For Three Broad Innovatmentioning

confidence: 99%

Surgery by Infrared Vision

Brioschi¹,

Malafaia²,

Costa³

et al. 2004

RET

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This paper is about the development, uses and advantages of infrared thermography. Its principles had already been used by old civilizations as a manner of diseases diagnosis. The discovery of the infrared waves and its heating power happened on 1800, but its use in modern Medicine as a diagnosis method was only possible because of the scientific and technological development demanded by the Great Wars, in the 20 th century. Here the authors present some news and promising surgery applications.

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Section: "The 20th Century Will Be Remembered For Three Broad Innovatmentioning

confidence: 99%

Surgery by Infrared Vision

Brioschi¹,

Malafaia²,

Costa³

et al. 2004

RET

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“…However, renal-transplant patients display a high incidence (57%) of DVT, although the onset of symptoms tends to be delayed to between 8 and 14 days postoperatively. The delay has been explained as the recovery time from hemodilution (6), as well as from the hypocoagulable state, possibly because of inhibited platelet function and the frequent use of systematic heparinization during hemodialysis and during the operative procedure (7)(8)(9). A second peak of DVT events after the initial postoperative period (8) has been seen particularly among patients with the risk factors of age older than 40 years, diabetes mellitus (6), secondary polycythemia, or high-dose steroid therapy, which produces direct actions as well as indirect hyperlipidemic effects to promote coagulation (7).…”

Section: Patients In the Sirolimus Group Showed A Strong Correlation mentioning

confidence: 99%

“…In addition to these factors, the incidence of thromboembolic events was increased when immunosuppression with azathioprine (Aza) was replaced by cyclosporine (CsA), particularly among patients with high drug concentrations (9,(12)(13)(14). The predisposition to thromboembolic events related to the drug has been attributed to increased adenosine diphosphate-induced platelet aggregation, thromboxane A 2 release, thromboplastin generation, and factor VII activity (15).…”

Section: Patients In the Sirolimus Group Showed A Strong Correlation mentioning

confidence: 99%

“…Vanrenterghem et al (17) reported 17 thromboembolic events in 13 patients (14.4%): namely, pulmonary emboli (nϭ10), DVTs (nϭ3), renal vein thrombosis (nϭ1), and hemorrhoidal thromboses (nϭ3). However, the incidence of DVT was lower with CsA immunosuppression when compared with a regimen including antilymphocyte serum, Aza, and prednisone (Pred) (7,9). Furthermore, one case report implicated mycophenolate mofetil in the increased occurrence of thrombotic events in a patient displaying the factor V Leiden mutation (2).…”

Section: Patients In the Sirolimus Group Showed A Strong Correlation mentioning

confidence: 99%

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Sirolimus does not increase the risk for postoperative thromboembolic events among renal transplant recipients1

Langer¹,

Kahan²

2003

Transplantation

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“…Thromboemboticcomptications constitute an important risk after renal transplantation (RT) (1)(2)(3)(4)(5)(6)(7). While thrombotic disease may strike either major or minor arteries in transplant patients, the venous system is more often ~~ted (7,8).…”

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Coagulation and Fibrinolysis During the First Year of Immunosuppressive Treatment in Renal Transplantation: Correspondence Between Hypercoagulable State and Steroid Therapy

Patrassi¹,

Sartori²,

Rigotti

et al. 1995

Clin Appl Thromb Hemost

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An increased incidence of thromboembolic complications has been reported after kidney transplantation, and hypercoagulability has been associated with immunosuppressive treatment, specifically with Cyclosporin A. Hypercorticism due to prolonged steroid therapy or to Cushing's disease has been associated with a similar hypercoagulable state and thrombotic risk. The aims of this study were first to evaluate coagulation and fibrinolytic behavior in 27 patients at different times during the first year after renal transplantation and then to compare the same patients' coagulation and fibrinolytic findings 1 month after transplantation with those of a normal control group and a group of Cushing's patients. Compared with normal controls, renal transplant patients and Cushing's patients showed a similar hypercoagulable and hypofibrinolytic state, with a significant shortening in activated partial thromboplastin time and increase in factor VIII-von Willebrand factor complex, tissue plasminogen activator concentration, and plasminogen activator inhibitor activity and concentration. Other test results in the two groups showed no differences. The same abnormalities were present in the renal transplant group for the entire period of study. Our results suggest that a hypercoagulable and hypofibrinolytic state persists almost 1 year after renal transplantation and that these abnormalities are very similar to those present in Cushing's disease. Steroid treatment seems to play a key role in determining thromboembolic risk after renal transplantation.

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Postoperative Deep Venous Thrombosis After Renal Transplantation

Cited by 40 publications

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Surgery by Infrared Vision

Surgery by Infrared Vision

Sirolimus does not increase the risk for postoperative thromboembolic events among renal transplant recipients1

Coagulation and Fibrinolysis During the First Year of Immunosuppressive Treatment in Renal Transplantation: Correspondence Between Hypercoagulable State and Steroid Therapy

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