Postoperative Cognitive Dysfunction: Mechanism and Prevention

Abstract

Postoperative cognitive dysfunction (POCD) refers to a condition characterized by impaired cognitive processing and reasoning, which can negatively affect perceptual abilities and play a crucial role in overall health. Factors such as age, educational attainment, history of mental illness, and the presence of comorbid diseases can influence the occurrence of postoperative cognitive dysfunction (POCD). Strategies aimed at preventing the occurrence of postoperative cognitive dysfunction (POCD) involve both surgical interventions and addressing patient-related issues, as well as optimizing the administration of anesthetics and conducting surgery in a stress-free manner. The benefits of reducing oxidative stress and inflammation in brain cells have been demonstrated. Postoperative recovery may be extended due to postoperative cognitive dysfunction (POCD). The studies conducted showed heterogeneity in terms of patient groups, methodology used to quantify POCD, and study design, making it challenging to draw generalizable conclusions. The prevalence of postoperative cognitive dysfunction (POCD) is a widespread health concern globally.