Postoperative Cognitive Dysfunction

Page, Valérie; Oglesby, Fiona; Armstrong, Richard A.

doi:10.1007/s40140-017-0238-1

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Postoperative cognitive dysfunction (POCD), which is a common postoperative neuropsychiatric complication, refers to neurocognitive dysfunction caused by anesthesia [ 1 , 2 ]. It is mainly characterized by progressive memory impairment, acute cognitive dysfunction or deterioration in cognitive function after surgery and may lead to the loss of independent living abilities in severe cases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is mainly characterized by progressive memory impairment, acute cognitive dysfunction or deterioration in cognitive function after surgery and may lead to the loss of independent living abilities in severe cases [ 3 ]. Recently, several reports revealed that most commonly used intravenous anesthetics can cause POCD [ 1 , 4 ]. Recent study demonstrates that patients had an incidence of POCD at 1 week of 19.2% compared with a background level in the control subjects of 4.0% [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of ginsenosides on memory impairment in propofol-anesthetized rats

Chen

Liu

et al. 2021

Bioengineered

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To investigate the effects of ginsenosides on the memory impairment in Sprague–Dawley rats (SD rats) after anesthesia through the administration of propofol SPF, SD rats were randomly divided into four groups: control group (Group I), propofol-treated group (Group II), low dose of ginsenosides-treated group (Group III) and high dose of ginsenosides-treated group (Group IV). These rats were subjected to fear memory test in shuttle box, Y-maze test and Morris water maze test. Immediately after the test, the expression levels of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) were further detected by ELISA method. Ginsenosides could ameliorate the impairment on the functions of fear memory, working memory and spatial memory in rats caused by anesthesia via the injection of Propofol. Furthermore, the expression levels of NGF and BDNF on rat hippocampus were significant increased by the treatment of ginsenosides at both two doses compared with the control group (both P < 0.05). Ginsenosides hold potential to be developed as a novel therapeutic agent for those patients suffering from postoperative cognitive dysfunction caused by anesthesia via the treatment of propofol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of ginsenosides on memory impairment in propofol-anesthetized rats

Chen

Liu

et al. 2021

Bioengineered

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“…Postoperative cognitive dysfunction (POCD) is a common complication following surgery and hospitalization [1]. In 1955, Dr. Bedford first reported symptoms of cognitive changes and behavioral abnormalities in elderly patients who underwent general anesthesia, resulting in increasing research regarding cognitive impairment that occurs follow-ing various types of surgery, particularly cardiac surgery [2].…”

Section: Introductionmentioning

confidence: 99%

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Zhao

Yeung

et al. 2020

Oxidative Medicine and Cellular Longevity

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Postoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both patients and their families. Acupuncture has been suggested as an effective intervention for many neurological disorders. In recent years, there are increasing interest in the use of acupuncture to prevent and treat POCD. In this review, we summarized the clinical and preclinical evidence of acupuncture on POCD using a narrative approach and discussed the potential mechanisms involved. The experimental details and findings of studies were summarized in tables and analyzed. Most of the clinical studies suggested that acupuncture before surgery could reduce the incidence of POCD and reduce the levels of systematic inflammatory markers. However, their reliability is limited by methodological flaws. Animal studies showed that acupuncture reduced cognitive impairment and the associated pathology after various types of surgery. It is possible that acupuncture modulates inflammation, oxidative stress, synaptic changes, and other cellular events to mitigate POCD. In conclusion, acupuncture is a potential intervention for POCD. More clinical studies with good research design are required to confirm its effectiveness. At the same time, findings from animal studies will help reveal the protective mechanisms, in which systematic inflammation is likely to play a major role.

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“…The deficits can take the form of delirium in the early postoperative period or subtler cognitive deficits that can last for weeks to months. 11 These disorders are important to understand because they are associated with poor long-term outcomes, increased costs of care, prolonged hospitalization, and even death.…”

mentioning

confidence: 99%

“…Le déficit peut prendre la forme d'un délirium dans la phase postopératoire précoce ou de déficits cognitifs plus subtils qui peuvent durer des semaines ou des mois. 11 Ces troubles sont importants à comprendre parce qu'ils sont associés à une évolution à long terme défavorable, une augmentation du coût des soins, des hospitalisations prolongées, voire même des décès.…”

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Anesthesiology in the 21st century: our science is our destiny

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2018

Can J Anesth/J Can Anesth

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Postoperative Cognitive Dysfunction

Cited by 4 publications

References 33 publications

Effects of ginsenosides on memory impairment in propofol-anesthetized rats

Effects of ginsenosides on memory impairment in propofol-anesthetized rats

Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

Anesthesiology in the 21st century: our science is our destiny

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