Postoperative Cognitive and Single Photon Emission Computed Tomography Assessment of Patients with Resection of Perioperative High-risk Arteriovenous Malformations

Abstract

We studied the outcome of 10 patients who had undergone high-risk surgery for an arteriovenous malformation at our institution between November 1991 and November 1993. All of the lesions were located in the dominant (left) hemisphere. Perioperative risk was assessed by the location of the lesion in functionally eloquent cortex (seven patients) or deep structures (two patients) or the lesion's large volume (two patients). Our patients included six women and four men, and their ages ranged from 22 to 53 years (mean, 35.8). Our follow-up study included the evaluation of neurological sequelae but mainly emphasized the study of cognitive deficits (seven major functional clusters), the incidence of depression and behavioral changes, and the assessment of regional cerebral blood flow with single photon emission computed tomography. Six patients returned to a seemingly "normal" daily life with some minor deficits postoperatively, three developed contralateral hemiparesis, and one had disabling cognitive deficits. Our comprehensive cognitive assessment, in particular, showed that although patients might appear "normal" on a routine neurological examination, most patients showed a mild deficit in at least one cognitive function and three were severely impaired. In addition, the single photon emission computed tomographic studies pointed out hypoperfusion in more extensive regions than the surgical defects shown by magnetic resonance imaging or computed tomographic studies. These single photon emission computed tomography images helped to explain some of the cognitive and behavioral changes better than the anatomic studies. This information will make it possible for the physician to offer continuing supportive care for the patient in postoperative transition to normal life activities.

Natural course of the arteriovenous malformations of the brain initially presented by hemorrhage – analysis of a clinical series of 39 patients

“…Comparative studies show that annual risk for occurrence of the bleeding from AVM of the brain is 2-4% annually and it is followed by death outcome in 10% of cases and neurological deficit in 50% of cases (7,19,21,27,31).…”