“…Step two, which is reinsertion of the guidewire through the accessory channel of the cholangioscope to locate the targeted bile duct and calculus, also has its advantages. For example, in cases of complicated hepatolithiasis, where repeated manipulation of the cholangioscope is necessary to accurately locate the exact position of calculi, and where the vision is obscured by the constant irrigation, basket extraction and lithotripsy, the guidewire can serve as a road sign, indicating the exact path to target the calculi. In addition, the volume of saline flowing into the intestine is significantly less in the wire‐guided procedure, which is important to reduce the incidence of adverse reactions such as diarrhea.…”