Postoperative chest wound infections in patients requiring coronary bypass

Sutherland, Robert; Martinez, H.E.; Guynes, W.A.; Miller, LaWayne

doi:10.1016/s0022-5223(19)41455-4

Cited by 57 publications

(4 citation statements)

References 16 publications

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“…Mounting evidence suggests the association of decreased levels of BDNF in AD brains [66, 67]. Further, ICV-STZ infusion decreases the BDNF levels in rodents [4, 68] which indicates that an increase in oxidative stress reduces brain BDNF levels [69].…”

Section: Discussionmentioning

confidence: 99%

S-Nitrosoglutathione Attenuates Oxidative Stress and Improves Retention Memory Dysfunctions in Intra-Cerebroventricular-Streptozotocin Rat Model of Sporadic Alzheimer’s Disease via Activation of BDNF and Nuclear Factor Erythroid 2-Related Factor-2 Antioxidant Signaling Pathway

Dubey,

Ray,

Dubey

et al. 2024

Neuropsychobiology

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Introduction: The brain-derived neurotrophic factor (BDNF) and transcription nuclear factor erythroid 2-related factor-2 (NRF-2) play an important role in Alzheimer’s disease (AD). However, the interactive involvement of BDNF and NRF-2 in respect to antioxidant mechanisms in different parts of the AD brain is still unclear. Considering the above condition, used S-nitrosoglutathione (GSNO) to examine whether it modulates the BDNF and NRF-2 levels to activate signaling pathway to promote antioxidant levels in AD brains. Method: AD was induced by intracerebroventricular infusion of streptozotocin (ICV-STZ, 3 mg/kg) in Wistar rats. The effect of GSNO was analyzed by evaluating the retention of memory in months 1, 2, and 3. After the behavior study, rats were sacrificed and accessed the amyloid beta (Aβ)-40, Aβ42, glutathione (GSH), BDNF, and NRF-2 levels in the hippocampus, cortex, and amygdala tissue. Results: Pretreatment with GSNO (50 µg/kg/intraperitoneal/day) restored the BDNF, and NRF-2 levels toward normalcy as compared with ICV-STZ + saline-treated animals. Also, GSNO treatment reversed the oxidative stress and increased the GSH levels toward normal levels. Further, reduced Aβ levels and neuronal loss in different brain regions. As a result, GSNO treatment improved the cognitive deficits in ICV-STZ-treated rats. Conclusion: The results showed that endogenous nitric oxide donor GSNO improved the cognitive deficits and ICV-STZ-induced AD pathological conditions, possibly via attenuating the oxidative stress. Hence, the above finding supported that GSNO treatment may activate BDNF and NRF-2 antioxidant signaling pathways in the AD brain to normalize oxidative stress, which is the main causative factor for ICV-STZ-induced AD pathogenesis.

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Section: Discussionmentioning

confidence: 99%

S-Nitrosoglutathione Attenuates Oxidative Stress and Improves Retention Memory Dysfunctions in Intra-Cerebroventricular-Streptozotocin Rat Model of Sporadic Alzheimer’s Disease via Activation of BDNF and Nuclear Factor Erythroid 2-Related Factor-2 Antioxidant Signaling Pathway

Dubey,

Ray,

Dubey

et al. 2024

Neuropsychobiology

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“…Estudios previos diseñados con este fin mostraron elevaciones de hasta 5 veces el valor basal, cuando existía mediastinitis con o sin otras condiciones mórbidas agregadas, tales como insuficiencia respiratoria, requerimiento de balón de contrapulsación, etc. 29 Por último, la mortalidad reportada en los pacientes con MPQ oscila entre 8,6 y 77%, 4,16,13,28 siendo en nuestra serie de 33%, lo que expresa claramente la gravedad y el impacto de esta infección.…”

Section: Discussionunclassified

Mediastinitis post-quirúrgica: Estudio caso - control

Clara

Stern

Barcán

et al. 2002

Rev. chil. infectol.

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We report the results of a case-control study of post-surgical mediastinitis, that we conducted for eighteen months. The aim of the study was to detect possible risk factors for mediastinal infection after cardiovascular surgery as well as to analyze related clinical features. Thirty episodes of mediastinal infections over 687 consecutive cardiovascular surgeries (4,4%) were registered during a control period of 18 month at Hospital Italiano of Buenos Aires, Argentina. Among all variables analyzed only the following were significantly associated to mediastinal infection in the postoperative period: time elapsed at the recovery unit (p < 0.01) total time with catheter placed in the pulmonary artery (p: 0.05) and the rate of postoperative complications (p < 0.01). Six patients with mediastinal infection (20%) had undergone reoperation shortly after main surgery compared to only 3 (5%) in the control group (p: 0.05). The association with surgical events may be related to post-surgical causation. The presence of fever, only after 72 hours from surgery, allowed discrimination between patients with and without mediastinal infection. All case patients showed abnormalities in surgical wound, and 28 of these patients (93%) had at least two local signs of infection. Among the 37 types of microorganisms isolated from sternal secretion, 22 (59%) were gram-positive cocci, with Staphylococcus as the predominant genus. While 40% of the recovered gram-positive bacteria were methicillin-resistant, only 50% of the gram-negative bacteria were sensitive to aminoglycosides and ceftazidime. The in-hospital time was significantly longer in patients with mediastinitis compared to control patients (p < 0.001). The mortality rate inpatients mediastinitis was 33%. In conclusion, mediastinal infection actually remains representing a severe and costly complication of cardiovascular surgery due to its high morbidity and mortality rates.

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“…Postoperative deep sternal wound infection (DSWI) is a serious complication in cardiac surgery affecting 1–5% of patients with high morbidity and mortality rates ranging from 5% to 46% . This is also one of the most common complications in open‐heart surgery along with heart failure and stroke .…”

Section: Introductionmentioning

confidence: 99%

Assessment of vacuum‐assisted closure therapy on the wound healing process in cardiac surgery

Pericleous

Dimitrakakis

Photiades

et al. 2015

International Wound Journal

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Postoperative deep sternal wound infection (DSWI) is a serious complication in cardiac surgery (1-5% of patients) with high mortality and morbidity rates. Vacuum-assisted closure (VAC) therapy has shown promising results in terms of wound healing process, postoperative hospital length of stay and lower in-hospital costs. The aim of our retrospective study is to report the outcome of patients with DSWI treated with VAC therapy and to assess the effect of contributory risk factors. Data of 52 patients who have been treated with VAC therapy in a single institution (study period: September 2003-March 2012) were collected electronically through PAtient Tracking System PATS and statistically analysed using SPSS version 20. Of the 52 patients (35 M: 17 F), 88·5% (n = 46) were solely treated with VAC therapy and 11·5% (n = 6) had additional plastic surgical intervention. Follow-up was complete (mean 33·8 months) with an overall mortality rate of 26·9% (n = 14) of whom 50% (n = 7) died in hospital. No death was related to VAC complications. Patient outcomes were affected by pre-operative, intra-operative and postoperative risk factors. Logistic EUROscore, postoperative hospital length of stay, advanced age, chronic obstructive pulmonary disease (COPD) and long-term corticosteroid treatment appear to be significant contributing factors in the long-term survival of patients treated with VAC therapy.

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Postoperative chest wound infections in patients requiring coronary bypass

Cited by 57 publications

References 16 publications

S-Nitrosoglutathione Attenuates Oxidative Stress and Improves Retention Memory Dysfunctions in Intra-Cerebroventricular-Streptozotocin Rat Model of Sporadic Alzheimer’s Disease via Activation of BDNF and Nuclear Factor Erythroid 2-Related Factor-2 Antioxidant Signaling Pathway

S-Nitrosoglutathione Attenuates Oxidative Stress and Improves Retention Memory Dysfunctions in Intra-Cerebroventricular-Streptozotocin Rat Model of Sporadic Alzheimer’s Disease via Activation of BDNF and Nuclear Factor Erythroid 2-Related Factor-2 Antioxidant Signaling Pathway

Mediastinitis post-quirúrgica: Estudio caso - control

Assessment of vacuum‐assisted closure therapy on the wound healing process in cardiac surgery

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