2011
DOI: 10.5402/2011/203179
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Postoperative Atrial Fibrillation

Abstract: Postoperative atrial fibrillation (POAF) is common among surgical patients and associated with a worse outcome. Pathophysiology of POAF is not fully disclosed, and several perioperative factors could be involved. Direct cardiac stimulation from perioperative use of catecholamines or increased sympathetic outflow from volume loss/anaemia/pain may play a role. Metabolic alterations, such as hypo-/hyperglycaemia and electrolyte disturbances, may also contribute to POAF. Moreover, inflammation, both systemic and l… Show more

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Cited by 82 publications
(72 citation statements)
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“…7,[40][41][42][43] Fewer data exist regarding mechanisms of PAF after pulmonary resection; it may be associated with various surgical stresses, such as excitation of sympathetic nerve activity, right ventricular overload, hypoxia, and systemic inflammatory responses. 2,44 The NT-proBNP level increases have been found in several clinical conditions, such as left ventricular hypertrophy, hypertension, left atrial enlargement, and heart failure. 45 In 2004, Wazni et al reported that increased BNP levels may predict PAF in patients undergoing cardiac surgery.…”
Section: Discussionmentioning
confidence: 99%
“…7,[40][41][42][43] Fewer data exist regarding mechanisms of PAF after pulmonary resection; it may be associated with various surgical stresses, such as excitation of sympathetic nerve activity, right ventricular overload, hypoxia, and systemic inflammatory responses. 2,44 The NT-proBNP level increases have been found in several clinical conditions, such as left ventricular hypertrophy, hypertension, left atrial enlargement, and heart failure. 45 In 2004, Wazni et al reported that increased BNP levels may predict PAF in patients undergoing cardiac surgery.…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have shown that this pro-inflammatory state may also be reflected to a lesser extent in the systemic circulation. Some inflammatory markers in the serum of post-operative cardiac surgery patients have appeared elevated and correlated with increased occurrences of cardiac dysfunction and atrial fibrillation [6][7][8]. We have recently proposed that the focus for the initiation of the pro-inflammatory response after surgery is the post-operative pericardial fluid (PO-PCF) and that the oxidative stress in this compartment is more severe than in the blood [5].…”
Section: Introductionmentioning
confidence: 99%
“…It was connected with increased intensive care utilization and hospital length of stay, morbidity, mortality, hospital readmissions, and longterm risk of stroke [17]. Besides, the prevalence of POAF was 16%-46% following cardiothoracic surgery and was 0.4%-12% following noncardiothoracic surgery [19]. In lung cancer, AF is most frequently seen during thoracic surgery, especially pulmonary resection [20].…”
Section: Postoperative Af (Poaf) In Cancermentioning
confidence: 98%