Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs

Marucio, Rodrigo Luiz; Luna, Stélio Pacca Loureiro; Neto, Francisco José Teixeira; Minto, B. W.; Hatschbach, Eduardo

doi:10.2460/ajvr.69.7.854

Cited by 21 publications

(25 citation statements)

References 19 publications

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“…Although other canine pain studies have validated the pain VAS [44], [45], different treatment effects on mean VAS scores following trochleoplasty were not demonstrated in this study. The VAS might have provided systematic error, particularly when measuring pain at baseline (floor effect) and during the postoperative period (ceiling effect).…”

Section: Discussionmentioning

confidence: 57%

Validation of Orthopedic Postoperative Pain Assessment Methods for Dogs: A Prospective, Blinded, Randomized, Placebo-Controlled Study

et al. 2012

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In the context of translational research, there is growing interest in studying surgical orthopedic pain management approaches that are common to humans and dogs. The validity of postoperative pain assessment methods is uncertain with regards to responsiveness and the potential interference of analgesia. The hypothesis was that video analysis (as a reference), electrodermal activity, and two subjective pain scales (VAS and 4A-VET) would detect different levels of pain intensity in dogs after a standardized trochleoplasty procedure. In this prospective, blinded, randomized study, postoperative pain was assessed in 25 healthy dogs during a 48-hour time frame (T). Pain was managed with placebo (Group 1, n = 10), preemptive and multimodal analgesia (Group 2, n = 5), or preemptive analgesia consisting in oral tramadol (Group 3, n = 10). Changes over time among groups were analyzed using generalized estimating equations. Multivariate regression tested the significance of relationships between pain scales and video analysis. Video analysis identified that one orthopedic behavior, namely ‘Walking with full weight bearing’ of the operated leg, decreased more in Group 1 at T24 (indicative of pain), whereas three behaviors indicative of sedation decreased in Group 2 at T24 (all p<0.004). Electrodermal activity was higher in Group 1 than in Groups 2 and 3 until T1 (p<0.0003). The VAS was not responsive. 4A-VET showed divergent results as its orthopedic component (4A-VETleg) detected lower pain in Group 2 until T12 (p<0.0009), but its interactive component (4A-VETbeh) was increased in Group 2 from T12 to T48 (p<0.001). Concurrent validity established that 4A-VETleg scores the painful orthopedic condition accurately and that pain assessment through 4A-VETbeh and VAS was severely biased by the sedative side-effect of the analgesics. Finally, the video analysis offered a concise template for assessment in dogs with acute orthopedic pain. However, subjective pain quantification methods and electrodermal activity need further investigation.

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Section: Discussionmentioning

confidence: 57%

Validation of Orthopedic Postoperative Pain Assessment Methods for Dogs: A Prospective, Blinded, Randomized, Placebo-Controlled Study

et al. 2012

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“…The dogs with fractures had an average CMPS-SF score of ≥5/20 and OP-VAS over 40 mm, which, according to what has previously been reported, indicates pain and the need for additional analgesic treatment [11, 54]. Surprisingly, the S-VAS scores measured during collection of saliva and blood samples were significantly lower in dogs with traumatic bone fractures compared to the healthy dogs.…”

Section: Discussionmentioning

confidence: 73%

“…The level of pain may have been underestimated because of the sedative effect of morphine affecting some of the parameters [54, 55]. However, despite receiving morphine analgesia, the subjective pain assessment scores were still higher in dogs with fractures than in the healthy dogs, indicating a suboptimal analgesic effect.…”

Section: Discussionmentioning

confidence: 99%

Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures

et al. 2017

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BackgroundTraumatic bone fractures cause moderate to severe pain, which needs to be minimized for optimal recovery and animal welfare, illustrating the need for reliable objective pain biomarkers for use in a clinical setting. The objectives of this study were to investigate catestatin (CST) and vasostatin (VS) concentrations as two new potential biomarkers, and cortisol concentrations, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF), and visual analog scale (VAS) in dogs suffering from traumatic bone fractures before and after morphine administration in comparison with healthy dogs.MethodsFourteen dogs with hind limb or pelvic fractures and thirty healthy dogs were included. Dogs with fractures were divided into four groups according to analgesia received before participation. Physical examination, CMPS-SF, pain and stress behavior VAS scores were recorded in all dogs. Saliva and blood were collected once in healthy dogs and in dogs with fractures before and 35–70 min after morphine administration. Blood samples were analyzed for CST, VS, and cortisol. Saliva volumes, however, were insufficient for analysis.ResultsCatestatin and cortisol concentrations, and CMPS-SF, and VAS scores differed significantly between dogs with fractures prior to morphine administration and healthy dogs. After morphine administration, dogs with fractures had significantly decreased CMPS-SF and VAS scores and, compared to healthy dogs, CST concentrations, CMPS-SF, and VAS scores still differed significantly. However, CST concentrations remained largely within the normal range. Absolute delta values for CST significantly correlated with delta values for CMPS-SF. Catestatin and cortisol did not differ significantly before and after morphine administration. Vasostatin concentrations did not differ significantly between groups.ConclusionsCatestatin and cortisol concentrations, CMPS-SF, and VAS scores differed significantly in the dogs with traumatic bone fractures compared to the healthy dogs. Morphine treatment partially relieved pain and stress according to the subjective but not according to the objective assessments performed. However, because of the large degree of overlap with normal values, our results suggest that plasma CST concentrations have a limited potential as a clinically useful biomarker for pain-induced stress.

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“…Também devido à grande incidência de cães SRD no estudo, não foi possível a formação de um grupo composto por um determinado padrão racial corroborando com autores que empregaram cães de diversas raças em seus estudos sobre a dor (Grisneaux et al, 1999;Slingsby e Waterman-Pearson, 2001;Mastrocinque e Fantoni, 2003;Marucio et al, 2008).…”

Section: As Raças Mais Incluídas No Estudo Foram a Srd Seguidas Do Cunclassified

“…Escalas de avaliação da analgesia são muito utilizadas para determinação do grau de dor e controle no tratamento analgésico, dentre elas a Escala Analógica Visual (EAV) bastante utilizada também na veterinária (Dobbins et al, 2002;Slingsby et al, 2006;Marucio et al, 2008). No estudo em tela, utilizou-se a ENV, empregada rotineiramente no hospital da FMVZ-USP, por ser de fácil uso para avaliação da dor e do tratamento analgésico, sendo também utilizada em estudos de dor na veterinária (Fowler et al, 2003;Morton et al, 2005;Bergmann et al, 2007;Quinn et al, 2007).…”

Section: As Raças Mais Incluídas No Estudo Foram a Srd Seguidas Do Cunclassified

Estudo comparativo do emprego de tramadol, codeína e cetoprofeno no controle da dor pós-operatória e nos níveis de glicose, cortisol e interleucina-6 em cães submetidos à maxilectomia ou mandibulectomia

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Postoperative analgesic effects of epidural administration of neostigmine alone or in combination with morphine in ovariohysterectomized dogs

Cited by 21 publications

References 19 publications

Validation of Orthopedic Postoperative Pain Assessment Methods for Dogs: A Prospective, Blinded, Randomized, Placebo-Controlled Study

Validation of Orthopedic Postoperative Pain Assessment Methods for Dogs: A Prospective, Blinded, Randomized, Placebo-Controlled Study

Catestatin, vasostatin, cortisol, and pain assessments in dogs suffering from traumatic bone fractures

Estudo comparativo do emprego de tramadol, codeína e cetoprofeno no controle da dor pós-operatória e nos níveis de glicose, cortisol e interleucina-6 em cães submetidos à maxilectomia ou mandibulectomia

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