Postoperative analgesic effects of dexketoprofen, buprenorphine and tramadol in dogs undergoing ovariohysterectomy

Morgaz, Juán; Navarrete, Rocío; Muñoz-Rascón, Pilar; Domínguez, Juan M.; Fernández-Sarmiento, José Andrés; Gómez-Villamandos, R.J.; Granados, Miguel Ángel Núñez

doi:10.1016/j.rvsc.2013.03.003

Cited by 39 publications

(62 citation statements)

References 32 publications

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“…Ovariohysterectomy is a surgical procedure widely used in analgesic studies in dogs, since it causes moderate or severe postoperative pain (6,15).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in humans confi rmed that preemptive analgesia reduces postoperative pain and the need for analgesics (1)(2)(3). Perioperative elimination of pain facilitates recovery from anesthesia and increases patient well-being (4)(5)(6). Undesirable effects of postoperative pain in surgical patients, such as loss of appetite, self-trauma, maladaptive physiological response or maladaptive behaviour, prolong time to recovery (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Ketoprofen is a non-steroidal anti-infl ammatory drug (NSAID) of the arylpropionic acid class with analgesic and antipyretic effects (6,9). It has been widely used as an analgesic in dogs (6,10,11).…”

Section: Introductionmentioning

confidence: 99%

“…It has been widely used as an analgesic in dogs (6,10,11). It acts by inhibiting cyclooxygenase enzyme-1 (COX-1) and/ /or COX-2, thereby inhibiting the synthesis of prostaglandins both in infl ammatory processes and in healthy tissue (6,12). Dexketoprofen trometamol is the water soluble salt of the S-isomer of ketoprofen, which is racemic (13,14).…”

Section: Introductionmentioning

confidence: 99%

“…Few study reports are available on the analgesic effi cacy of dexketoprofen in veterinary medicine (6).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of preemptive dexketoprofen trometamol effect on blood chemistry, vital signs and postoperative pain in dogs undergoing ovariohysterectomy

Saritas¹,

Sarıtaş²,

Pamuk³

et al. 2015

BLL

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Abstract:Objective: To investigate the postoperative analgesic effects of preemptive dexketoprofen trometamol in dogs subjected to ovariohysterectomy (OHE). Material and methods: Seventeen adult bitches of various breeds were used in this study. The dogs were randomly allocated into of two groups. Subjects in the dexketoprofen trometamol (DEX) group (n = 10), received intravenous (i.v.) dexketoprofen trometamol, 1 mg/kg, 15 minutes before premedication, while those assigned to the control (C) group (n = 7) were given no analgesics prior to premedication. Pain level was assessed by two researchers before the administration of anaesthesia (15 minutes before start) and 0, 1, 2, 4 and 6 hours after surgery. A modifi ed University of Melbourne Pain Scale (UMPS) was used to evaluate pain in both groups. Results: Serum cortisol level changed from 0 to 1 h and from 0 to 1 to 4 h were compared between the groups; the increase in the C group was statistically signifi cant. The modifi ed UMPS was applied to both groups at baseline and postoperative 1, 2, 4 and 6 h. According to this test, the values for DEX were signifi cantly lower than controls at 4 and 6 h (p < 0.001). Conclusion: Stable vital signs with unchanged biochemical parameters on dexketoprofen administration are a promising fi nding. The clinical advantage shown by the pain scale difference and the low serum cortisol levels should qualify dexketoprofen for preemptive pain management in dogs (Tab. 5, Fig. 2, Ref. 30). Text in PDF www.elis.sk.

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“…Ovariohysterectomy is a surgical procedure widely used in analgesic studies in dogs, since it causes moderate or severe postoperative pain (6,15).…”

Section: Discussionmentioning

confidence: 99%