Postoperative analgesia with epidural bupivacaine and low‐dose fentanyl ‐ a comparison of two concentrations

Sjöström, Staffan; Bläss, J.

doi:10.1111/j.1399-6576.1998.tb05321.x

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Studies have been done in the past to ascertain the optimal doses and concentrations of epidural local anaesthetics, opiods and other adjuvants so as to get the best of the postoperative epidural analgesia and the least of the side effects [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Effect of Epidural Bupivacaine, Epidural Bupivacaine Plus Fentanyl and Epidural Bupivacaine Plus Clonidine on Postoperative Analgesia after Hip Surgery

Karnawat¹

2013

J Anesth Clin Res

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Background: Management of postoperative pain is one of the most challenging and gratifying domains of anaesthesia. Search for an ideal adjuvant for post operative epidural analgesia still continues. Methods: A total of 75 healthy patients of both sexes in age group 50-80 years belonging to ASA status I and II posted for elective hip surgeries were enrolled and randomly divided into three groups of 25 each-Group B, Group BF and Group BC All the patients in the three groups received 3.5 ml Bupivacaine heavy (0.5%) intrathecally before surgery, followed by epidural bolus postoperatively, at 'two segment sensory regression' in following manner: initial bolus made to 10 ml with each group given-7 ml of 0.125% Bupivacaine and 3 ml distilled water with adjuvant as 50 µg Fentanyl in group BF and 100 µg Clonidine in group BC. Top up of 7 ml was given to each group with 5 ml of 0.125% Bupivacaine and 2 ml distilled water with adjuvant as 50 μg Fentanyl in group BF and 75 μg Clonidine in group BC. Results: There was no statistically significant difference between the demographic profile. VAS scores were found to be better in Group BF and BC at most of the times and these scores were significantly lower than Group B. Rescue analgesia was required in 12% patients in Group B while none of the patients in Group BF or Group BC required rescue analgesia. Nausea, vomiting and pruritus were observed in 52% of the patients in Group BF and in none of the patients in Group BC and Group B.Degree of sedation was significantly more in Group BC when compared with Group BF and Group B. Conclusion: Combination of Bupivacaine-Clonidine was found to be a better option than Bupivacaine-Fentanyl for postoperative epidural analgesia in hip surgery patients. J o u rn al of A n e s th es ia & C li n ic a l Resea rc h

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Section: Introductionmentioning

confidence: 99%

Comparison of Effect of Epidural Bupivacaine, Epidural Bupivacaine Plus Fentanyl and Epidural Bupivacaine Plus Clonidine on Postoperative Analgesia after Hip Surgery

Karnawat¹

2013

J Anesth Clin Res

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“…37,[52][53][54][55] RCTs are equivocal regarding respiratory depression, frequency of hypoxemia, hypercarbia, and sedation or somnolence when lower doses of singleinjection intrathecal opioids are compared with higher doses (Category A1-E evidence). 63,64 Survey Findings for Dose Selection: Both the consultants and the ASA members strongly agree that the lowest efficacious dose of neuraxial opioids should be administered to minimize the risk of respiratory depression. 63,64 Survey Findings for Dose Selection: Both the consultants and the ASA members strongly agree that the lowest efficacious dose of neuraxial opioids should be administered to minimize the risk of respiratory depression.…”

Section: Practice Parametersmentioning

confidence: 99%

Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration

2016

Anesthesiology

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The American Society of Anesthesiologists Committee on Standards and Practice Parameters and the Task Force on Neuraxial Opioids and the American Society of Regional Anesthesia and Pain Medicine present an updated report of the Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration. Supplemental Digital Content is available in the text.

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Is the combination of epidural clonidine–levobupivacaine has same analgesic efficacy and safety as the combination fentanyl–levobupivacaine after radical cystectomy?

Mahran

Ibrahim

2014

Egyptian Journal of Anaesthesia

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Postoperative analgesia with epidural bupivacaine and low‐dose fentanyl ‐ a comparison of two concentrations

Cited by 7 publications

References 20 publications

Comparison of Effect of Epidural Bupivacaine, Epidural Bupivacaine Plus Fentanyl and Epidural Bupivacaine Plus Clonidine on Postoperative Analgesia after Hip Surgery

Comparison of Effect of Epidural Bupivacaine, Epidural Bupivacaine Plus Fentanyl and Epidural Bupivacaine Plus Clonidine on Postoperative Analgesia after Hip Surgery

Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration

Is the combination of epidural clonidine–levobupivacaine has same analgesic efficacy and safety as the combination fentanyl–levobupivacaine after radical cystectomy?

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