Postoperative Analgesia After Arthroscopic Knee Surgery: A Randomized, Prospective, Double-Blind Study of Intravenous Regional Analgesia Versus Intra-articular Analgesia

Graham, N.; Shanahan, M.D.G.; Barry, P. Creagh; Burgert, Sabine; Talkhani, Imitayaz

doi:10.1016/s0749-8063(00)90129-4

Cited by 21 publications

(7 citation statements)

References 21 publications

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“…Trials in which morphine was given in combination with other drugs were not included, [13][14][15][16][17][18][19][20][21][22][23][24][25] nor were those in which knee arthroplasty was performed 26 or nonarthroscopic reconstruction of the anterior cruciate ligament. 27,28 Excluded was also 1 trial comparing the additional pain control by IA morphine with that produced by peripheral nerve blocks.…”

Section: Resultsmentioning

confidence: 99%

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Rosseland

2005

Regional Anesthesia and Pain Medicine

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There are few well-controlled RCTs on IA morphine, and the negative trials of higher quality counter the evidence from the numerous positive ones of lower quality. The quality of most published trials is poor, and performing meta-analysis on these data is not meaningful. Properly controlled trials, in which early postoperative pain intensity is documented, suggest that there is no added analgesic effect of IA morphine compared with saline alone.

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Section: Resultsmentioning

confidence: 99%

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

Rosseland

2005

Regional Anesthesia and Pain Medicine

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“…The IA route provides local analgesia and avoids potential undesirable systemic effects (sedation, bradycardia, nausea, vomiting, etc.). Several authors have evaluated the IA administration of different analgesic drugs in humans (Kalso et al ., ; Møiniche et al ., ; Buerkle et al ., ; Graham et al ., ; Joshi et al ., ; Gupta et al ., ; Drosos et al ., ; Alagöl et al ., ; Kazemi et al ., ; Tan et al ., ; & Zeidan et al ., ).…”

Section: Introductionmentioning

confidence: 97%

A pharmacokinetic/clinical approach to postulate a local action of intra‐articular xylazine administration in the horse: a preliminary study

Salvo

Rocca

Bazzica

et al. 2014

Vet Pharm & Therapeutics

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The study aims to evaluate whether the analgesic effect of intra-articular (IA) route of xylazine administered to horses following arthroscopic surgery is due to a local or a systemic action. Two connected studies were performed. In the first, 1 mg/kg b.w. of xylazine was injected IA, and blood samples were taken to assess drug systemic absorption. In addition, systemic effects of the drug (sedation, ataxia or reduction of respiratory and cardiac rate) were registered. Control horses injected with saline IA were included in the study to exclude the influence of anaesthesia in the occurrence of these manifestations. In the second study, 1 mg/kg b.w. of xylazine was administered intravenously (i.v.) in healthy horses. Blood samples were collected to determine the concentrations of xylazine, and the same signs of systemic effects of the drug were recorded. By correlating these parameters, a systemic 'no effect' concentration was defined. Pharmacokinetic data after IA administration resulted in some xylazine absorption (bioavailability equal to 58.12%) with values above the systemic 'no effect' concentration. The occurrence of some signs related to systemic effects in horses receiving IA xylazine was significant compared with horses receiving saline. In conclusion, a systemic action of the drug after IA administration cannot be excluded.

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“…¶ Several studies have compared intra-articular injection and femoral block. These studies reported conflicting results, showing either no difference among these methods 17 or a preference for the femoral block. 7,18 The current investigation involved the comparison of 2 extant postoperative pain control protocols being used in our facility.…”

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confidence: 99%

Continuous Femoral Nerve Block versus Intra-articular Injection for Pain Control after Anterior Cruciate Ligament Reconstruction

2006

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Postoperative Analgesia After Arthroscopic Knee Surgery: A Randomized, Prospective, Double-Blind Study of Intravenous Regional Analgesia Versus Intra-articular Analgesia

Cited by 21 publications

References 21 publications

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

No evidence for analgesic effect of intra-articular morphine after knee arthroscopy: A qualitative systematic review

A pharmacokinetic/clinical approach to postulate a local action of intra‐articular xylazine administration in the horse: a preliminary study

Continuous Femoral Nerve Block versus Intra-articular Injection for Pain Control after Anterior Cruciate Ligament Reconstruction

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