Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud’s Phenomenon: A Prospective, Controlled Study

Maga, Paweł; Henry, Brandon Michael; Kmiotek, Elizabeth; Gregorczyk-Maga, Iwona; Kaczmarczyk, Paweł; Tomaszewski, Krzysztof A.; Niżankowski, Rafał

doi:10.1155/2016/9645705

Cited by 9 publications

(6 citation statements)

References 43 publications

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“…With respect to temperature, the current results were consistent with previous studies [ 32 , 33 , 34 ] that showed similar findings for temperature records before and after CST and recovery patterns in PRP and SRP participants and the healthy controls. The blood flow measurements were also consistent with previous studies [ 35 , 36 , 37 , 38 ] that reported lower baseline blood flow in RP patients than in the controls. Furthermore, these authors [ 35 , 38 ] found no significant difference in the basal blood flow between the PRP and SRP groups.…”

Section: Discussionsupporting

confidence: 91%

Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon

Tapia-Haro,

García-Ríos,

Castro-Sánchez

et al. 2023

Diagnostics

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This study aimed to compare vascular involvement, hand functionality, and upper limb disability between Raynaud’s phenomenon participants and controls. Also, we analyzed the relationships between vascular impairment, mobility, and strength with disability in this Raynaud population. We conducted a case–control study with fifty-seven participants. We registered sociodemographic and clinical data; vascular variables (temperature, cold test, blood flow, and oxygen saturation); functional variables (pinch strength, range of motion), and disability (Shortened Disabilities of the Arm, Shoulder and Hand Questionnaire) (Q-DASH). Raynaud participants present more disability in all Q-DASH subscales, lower hands’ temperature pre and post cold test, decreased blood flow on radial artery, decreased ranges of motions at passive extension of index finger, and active flexion and extension of thumb than the healthy controls. The multivariate regression analysis showed that extension of the index finger, lateral pinch strength, and oxygen saturation were significantly associated with disability in RP, almost the 55% of the total variance on the upper limb, 27% at sports/arts, and 42% at work. Our findings suggest that RP has a disabling effect on the upper extremities and a practice of activities in people who suffer it. Also, disability in Raynaud seems to be more related with hand mobility and strength impairment than vascular injury.

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Section: Discussionsupporting

confidence: 91%

Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon

Tapia-Haro,

García-Ríos,

Castro-Sánchez

et al. 2023

Diagnostics

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“…45 Some authors reported that measuring the baseline microvascular blood flow and then time-to-peak flow after occlusion using laser Doppler flowmetry may be a highly accurate test for differentiating patients with primary RP from healthy controls. 45 The postocclusive time-to-peak flow had a superior specificity of 90% as compared with 66% for baseline microvascular flow. 45 Laser Doppler imaging, speckle contrast analysis, and speckle contrast imaging are characterized by a higher reliability, but they are more expensive and are not yet widely accessible.…”

Section: Evaluation Of the Microcirculation Capillaroscopymentioning

confidence: 91%

Recent advances in the workup and management of Raynaud’s phenomenon

Lis‐Święty

2019

Polish Archives of Internal Medicine

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oxide synthase 1 gene as significantly correlated with RP in the general population. 4 Major risk factors for primary RP include, in addition to the female sex and family history, a previous sensation of cold hands, migraine, cardiovascular diseases, decreased body mass index, manual occupation (not including vibration tool use), and estrogen replacement therapy. 3-6 Cigarette smoking and alcohol consumption are still of unclear significance when concerning the prevalence of primary RP. 7 Secondary RP associated with a known disease, mainly with systemic sclerosis (SSc) (>80% of patients) or other connective tissue diseases (CTDs), is rare and accounts for 10% to 20% of all RP cases. 8 Other common causes of secondary RP include diseases of arteries in the upper limbs (60% of RP occurring in individuals older than 60 years), malignancies, endocrine diseases, occupational syndromes, hematologic disorders, and infections (TABLE 1). 8,9 In addition, several Introduction Raynaud phenomenon (RP) is defined as recurrent, reversible episodes of vasospasm involving peripheral small vessels of the fingers and toes, at times also of the other acral sites (nose, ears, oral mucosa, lips, or nipples), when exposed to a cold environment or stressful situation. 1 This is characterized by a series of color changes in the affected area: first white (lack of blood flow), then bluish (deoxygenation of remaining blood), and red (reperfusion). Attacks can cause distal pain, burning, numbness, and paresthesia. 2 Regarding its etiology, RP is classified as primary (idiopathic) or secondary. Primary RP, which is an isolated finding without an underlying pathology, is common, occurring in about 5% of the general population living in areas with cold climates. 3 The prevalence of RP is higher in women (female-to-male ratio of 9 to 1). There is an associated genetic predisposition: one polymorphic variant was identified within the nitric

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“…With regard to vascular endothelial studies, the LDF method is used to assess reactive hyperaemia in the vascular bed of cutaneous vessels. Laser flow meters are well suited for recording the early component of the hyperaemic response associated with rapid dilation of resistance-type vessels (skin arterioles) [41,42].…”

Section: Laser Doppler Flowmetry (Ldf) Methodsmentioning

confidence: 99%

Non-invasive assessment of endothelial function — a review of available methods

Musz¹,

Podhajski

Grzelakowska

2021

Medical Research Journal

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The key role of the endothelium in vascular-dependent diseases led to an increase in scientific interest in examining the endothelial function as a tool for screening, as well as for monitoring of the disease and its treatment. In the period from 2016 till 2019, a high level of scientific interest in the assessment of endothelial function has been observed, as expressed in the number of published clinical trials between 369 and 477 per year with the total number of subjects between 49,634 and 75,934. Currently, none of the known methods of assessing vascular endothelial function is widely used in clinical practice. This may be a result of various factors: scientific (lack of standardization in terms of quantitative indicators of endothelial function), formal (lack of official recommendations for endothelial assessment), financial (the best-validated methods and devices are costly, which renders it unsustainable to use them in screening diagnostics) and technological (high susceptibility of many measurement methods to errors). Nevertheless, it can be expected that non-invasive methods for the early detection of endothelial dysfunction in screening programs will gradually gain importance.

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Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary Raynaud’s Phenomenon: A Prospective, Controlled Study

Cited by 9 publications

References 43 publications

Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon

Analysis of Hand Function, Upper Limb Disability, and Its Relationship with Peripheral Vascular Alterations in Raynaud’s Phenomenon

Recent advances in the workup and management of Raynaud’s phenomenon

Non-invasive assessment of endothelial function — a review of available methods

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