Postneuposurgical Candida Lusitaniae Meningitis

Rj, Leggiadro; Collins, Tracy

doi:10.1097/00006454-198805000-00026

Cited by 16 publications

(7 citation statements)

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“…C. lusitaniae fungemia has been associated with a high mortality rate because of its resistance to amphotericin B [3]. C. lusitaniae has also been reported to be resistant to other antifungal agents, such as 5-fluorocytosine and fluconazole [4][5][6][7].…”

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confidence: 99%

Candida lusitaniae: A Cause of Breakthrough Fungemia in Cancer Patients

Minari

Hachem

Raad

2001

Clinical Infectious Diseases

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Candida lusitaniae is an infrequent cause of fungemia. We identified 12 cases of C. lusitaniae fungemia that occurred at the University of Texas M. D. Anderson Cancer Center from 1988 to 1999. The mean age of patients was 48 years (range 20--70 years). Eight patients had hematologic malignancy or had received a bone marrow transplant, and 4 had a solid tumor. Most patients (75%) were neutropenic (<10(3)/mm(3)). Treatment with amphotericin B alone failed for 3 of 6 patients, irrespective of neutropenic status. Fluconazole was effective as a single agent in 3 patients with solid tumors. The combination of amphotericin B plus fluconazole was effective treatment for two-thirds of patients with hematologic malignancy, despite persistence of neutropenia. The mortality rate associated with C. lusitaniae infection was 25%. C. lusitaniae presents as breakthrough fungemia in immunocompromised patients and is associated with failure of amphotericin B therapy. Fluconazole may be a useful agent in the treatment of this infection.

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confidence: 99%

Candida lusitaniae: A Cause of Breakthrough Fungemia in Cancer Patients

Minari

Hachem

Raad

2001

Clinical Infectious Diseases

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“…Currently, echinocandins are drugs of choice in such cases because of their significant effect on biofilm form of yeasts (Cauda 2009). Infections of the CNS were treated successfully with a combination of amphotericin B and flucytosine before the introduction of new antifungals because of their synergism during penetration of the blood-brain barrier (Leggiadro and Collins 1988). It was impossible to apply this treatment strategy to our patient because of his allergic response to amphotericin B.…”

Section: Discussionmentioning

confidence: 96%

“…Sanchez and Cooper (1987) described a case of sepsis with subsequent meningitis in a neonate. Leggiadro and Collins (1988) reported C. lusitaniae meningitis in a child following neurosurgery for cerebral glioma. Sarma et al (1993) presented fatal meningitis in a previously healthy adult male.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of McRAPD for typing and importance of biofilm production in a case of nosocomial ventriculoperitoneal shunt infection caused by Candida lusitaniae

Hamal

Hanzen²,

Horn

et al. 2011

Folia Microbiol

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A case report of ventriculoperitoneal shunt infection caused by Candida lusitaniae in a 6-year-old patient with cerebral astrocytoma and obstructive hydrocephalus is presented briefly with emphasis on the course of antifungal treatment. Seven isolates recovered subsequently from the cerebrospinal fluid were studied retrospectively. To confirm identity, isolates were typed using pulsed-field gel electrophoresis and melting curve of random amplified polymorphic DNA (McRAPD). Further, the ability to form biofilm and its susceptibility to systemic antifungals were evaluated. Using McRAPD, identity of C. lusitaniae isolates showing slight microevolutionary changes in karyotypes was undoubtedly confirmed; successful application of numerical interpretation of McRAPD for typing is demonstrated here for the first time. The strain was also recognized as a strong biofilm producer. Moreover, minimum biofilm inhibitory concentrations were very high, in contrast to low antifungal minimum inhibitory concentrations of isolates. It can be concluded that McRAPD seems to be a simple and reliable method not only for identification but also for typing of yeasts. A ventriculoperitoneal shunt colonized by C. lusitaniae was revealed as the source of this nosocomial infection, and the ability of the strain to form biofilm on its surface likely caused treatment failure.

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“…was indeed rarely encountered as a human pathogen (4). More recently, C. lusitaniae has been recovered from a variety of human clinical specimens such as cerebrospinal fluid (5,6). Little is known about the risk factors for C. lusitaniae colonization and infection.…”

Section: Discussionmentioning

confidence: 99%