Postnatal Vitamin D Intake Modulates Hippocampal Learning and Memory in Adult Mice

Liang, Qiujuan; Cai, Chunhui; Duan, Dongxia; Hu, Xinyu; Hua, Wanhao; Jiang, Pei-Cheng; Zhang, Liu; Xu, Jun; Gao, Zhengliang

doi:10.3389/fnins.2018.00141

Cited by 20 publications

(8 citation statements)

References 73 publications

(82 reference statements)

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“…Vitamin D may be involved in the regulation of acetylcholine and clearing of amyloid beta, both of which are implicated in the pathogenesis of cognitive impairment in PD (120,121). Many studies demonstrate that the VDR and enzymes involved in D3 metabolism are expressed in the central nervous system, particularly in the areas of hippocampus (122,123), and animal studies have shown that vitamin D deficiency negatively affects hippocampal learning and memory through gene expression and neural development (124). These studies suggest potential mechanisms for the effect of vitamin D on cognitive impairment in PD, but more work is needed to determine if vitamin D status affects cognition in PD and whether supplementation may help prevent or improve cognitive decline.…”

Section: Non-motor Symptoms Cognitionmentioning

confidence: 99%

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms

Fullard

Duda

2020

Front. Neurol.

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Vitamin D is a fat-soluble secosteroid that exerts its effects by binding to the vitamin D receptor (VDR), through which it directly and indirectly modulates the expression of hundreds to thousands of genes. While originally known for its role in regulating calcium homeostasis and metabolism, vitamin D is now associated with many other health conditions, including Parkinson's disease (PD). A high prevalence of vitamin D deficiency has been noted in PD for at least the past two decades. These findings, along with the discovery that the VDR and 1α-hydroxylase, the enzyme that converts vitamin D to its active form, are highly expressed in the substantia nigra, led to the hypothesis that inadequate levels of circulating vitamin D may lead to dysfunction or cell death within the substantia nigra. Studies investigating the relationship between vitamin D status and PD, however, have been inconsistent. Two prospective studies examined the association between mid-life vitamin D levels and risk of PD and produced conflicting results-one demonstrated an increased risk for PD with lower mid-life vitamin D levels, and the other showed no association between vitamin D and PD risk. One of the most consistent findings in the literature is the inverse association between serum vitamin D level and motor symptom severity in cross-sectional studies. While these data suggest that vitamin D may modify the disease, another likely explanation is confounding due to limited mobility. Fall risk has been associated with vitamin D in PD, but more study is needed to determine if supplementation decreases falls, which has been demonstrated in the general population. The association between vitamin D and non-motor symptoms is less clear. There is some evidence that vitamin D is associated with verbal fluency and verbal memory in PD. Studies in PD have also shown associations between vitamin D status and mood, orthostatic hypotension and olfactory impairment in PD. While more research is needed, given the numerous potential benefits and limited risks, vitamin D level assessment in PD patients and supplementation for those with deficiency and insufficiency seems justified.

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Section: Non-motor Symptoms Cognitionmentioning

confidence: 99%

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms

Fullard

Duda

2020

Front. Neurol.

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“…A study with adult mice found that postnatal prolonged vitamin D deficiency or overdose impairs the development and physiology of the hippocampus in particular, with accompanying impairments in various brain functions including especially learning and memory [18]. The same study also showed that mice born with vitamin D deficiency had thinner cortices and enlarged lateral ventricles.…”

Section: Discussionmentioning

confidence: 93%

Effects of vitamin D on motor symptoms and cognitive functions in people with Parkinson’s disease

Yüksel¹,

Gürsoy²

2021

GSC Biol. and Pharm. Sci.

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Aim of the study: Parkinson’s disease is the second most common neurodegenerative disorder. The present study investigates the role of vitamin D deficiency thought to be one of the etiopathological and modifying factors in Parkinson’s disease that is known to be multifactorial. Materials and Methods: Designed as a retrospective review of medical records, this study compares the serum vitamin D levels of the idiopathic Parkinson’s disease patients with and without dementia to those of the healthy individuals with no metabolic/degenerative disorders. It also investigates the relationship between the patients’ Standardized Mini-Mental State Examination (SMMSE) and the Unified Parkinson’s Disease Rating Scale (UPDRS) scores and serum vitamin D levels to show the effects of vitamin D on motor symptoms and cognitive functions. Results: In this study, we compared the serum vitamin D levels of 40 Parkinson’s disease patients and 15 Parkinson’s disease patients with dementia to those of the control group comprising 30 healthy individuals. Vitamin D levels were 21,4±15,9 ng/mL in the control group; 16,5±6,4 ng/mL in Parkinson’s disease patients and 13,8±4,5 ng/mL in Parkinson’s disease patients with dementia. All the patient groups had significantly lower vitamin D levels than the control group (p<0,005). Within the Parkinson’s disease group, furthermore, the dementia group had lower vitamin D levels than the non-dementia group. Having examined the relationship between the SMMSE scores and serum vitamin D levels, we found a significant difference in the Parkinson’s disease dementia group (p: 0,020), as well as a relationship of 59,4% in the same direction. On the other hand, there was no significant difference in either patient group in the scores of UPDRS evaluating clinical disability. Conclusion: Consistent with the literature, the present study found that people with Parkinson’s disease had lower mean values of serum vitamin D levels than the control group and showed that serum vitamin D levels were correlated with the cognitive performance. However, the study could not find a relationship between the serum vitamin D levels and the motor performance.

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“…Latimer et al reported that in middle-aged rats subjected to 6-months of vitamin D manipulation through diet, serum calcidiol levels correlated with the performance of the animals in the Morris water maze task, and supraphysiological doses may be protective against mild cognitive impairment [110]. Liang et al performed a similarly designed study in mice, including a group with a supraphysiological dose of vitamin D. In their study, mice were fed life-long with a specific diet containing a higher level of calcium before they were behaviorally assessed at 6-weeks and 17-weeks of age [111]. They concluded that altered vitamin D intake had a significant impact on long-term memory and promoted memory loss (not only VDD but also the overdose were harmful) [111].…”

Section: Influence Of Vitamin D3 Deficiency/supplementation On Cognitive Impairment In Animal Modelsmentioning

confidence: 99%

“…Liang et al performed a similarly designed study in mice, including a group with a supraphysiological dose of vitamin D. In their study, mice were fed life-long with a specific diet containing a higher level of calcium before they were behaviorally assessed at 6-weeks and 17-weeks of age [111]. They concluded that altered vitamin D intake had a significant impact on long-term memory and promoted memory loss (not only VDD but also the overdose were harmful) [111].…”

Section: Influence Of Vitamin D3 Deficiency/supplementation On Cognitive Impairment In Animal Modelsmentioning

confidence: 99%

Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings

Gáll

Székely

2021

Nutrients

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Purpose of review: increasing evidence suggests that besides the several metabolic, endocrine, and immune functions of 1alpha,25-dihydroxyvitamin D (1,25(OH)2D), the neuronal effects of 1,25(OH)2D should also be considered an essential contributor to the development of cognition in the early years and its maintenance in aging. The developmental disabilities induced by vitamin D deficiency (VDD) include neurological disorders (e.g., attention deficit hyperactivity disorder, autism spectrum disorder, schizophrenia) characterized by cognitive dysfunction. On the other hand, VDD has frequently been associated with dementia of aging and neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s disease). Recent findings: various cells (i.e., neurons, astrocytes, and microglia) within the central nervous system (CNS) express vitamin D receptors (VDR). Moreover, some of them are capable of synthesizing and catabolizing 1,25(OH)2D via 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1) and 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) enzymes, respectively. Both 1,25(OH)2D and 25-hydroxyvitamin D were determined from different areas of the brain and their uneven distribution suggests that vitamin D signaling might have a paracrine or autocrine nature in the CNS. Although both cholecalciferol and 25-hydroxyvitamin D pass the blood–brain barrier, the influence of supplementation has not yet demonstrated to have a direct impact on neuronal functions. So, this review summarizes the existing evidence for the action of vitamin D on cognitive function in animal models and humans and discusses the possible pitfalls of therapeutic clinical translation.

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Postnatal Vitamin D Intake Modulates Hippocampal Learning and Memory in Adult Mice

Cited by 20 publications

References 73 publications

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms

A Review of the Relationship Between Vitamin D and Parkinson Disease Symptoms

Effects of vitamin D on motor symptoms and cognitive functions in people with Parkinson’s disease

Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings

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