Postnatal training of 129/Sv mice confirms the long-term influence of early exercising on the motor properties of mice

Serradj, Najet; Jamon, Marc

doi:10.1016/j.bbr.2016.04.035

Cited by 4 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Patrick et al (2014) showed that the interlimb coordination can be manipulated with a 4-week training, indicating experiencedependent learning at a young age (<10 months). In animals, early motor experience influences the muscle typology (Serradj and Jamon, 2016). Such impact of training procedures suggests that experience is required for normal development of locomotor behavior and that motor output in adults could be optimized by appropriate training during a defined period of motor development (Walton et al, 1992;Muir and Chu, 2002;Serradj and Jamon, 2016).…”

Section: Emergence Of Different Modes Of Locomotion During Growthmentioning

confidence: 99%

“…In animals, early motor experience influences the muscle typology (Serradj and Jamon, 2016). Such impact of training procedures suggests that experience is required for normal development of locomotor behavior and that motor output in adults could be optimized by appropriate training during a defined period of motor development (Walton et al, 1992;Muir and Chu, 2002;Serradj and Jamon, 2016). Accordingly, human infants undergoing daily stepping exercise exhibit an earlier onset of independent walk than untrained infants (Zelazo et al, 1972;Yang et al, 1998).…”

Section: Emergence Of Different Modes Of Locomotion During Growthmentioning

confidence: 99%

See 1 more Smart Citation

Emergence of Different Gaits in Infancy: Relationship Between Developing Neural Circuitries and Changing Biomechanics

Dewolf

Sylos-Labini

Cappellini

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

How does gait-specific pattern generation evolve in early infancy? The idea that neural and biomechanical mechanisms underlying mature walking and running differ to some extent and involve distinct spinal and supraspinal neural circuits is supported by various studies. Here we consider the issue of human gaits from the developmental point of view, from neonate stepping to adult mature gaits. While differentiating features of the walk and run are clearly distinct in adults, the gradual and progressive developmental bifurcation between the different gaits suggests considerable sharing of circuitry. Gaits development and their biomechanical determinants also depend on maturation of the musculoskeletal system. This review outlines the possible overlap in the neural and biomechanical control of walking and running in infancy, supporting the idea that gaits may be built starting from common, likely phylogenetically conserved elements. Bridging connections between movement mechanics and neural control of locomotion could have profound clinical implications for technological solutions to understand better locomotor development and to diagnose early motor deficits. We also consider the neuromuscular maturation time frame of gaits resulting from active practice of locomotion, underlying plasticity of development.

show abstract

Section: Emergence Of Different Modes Of Locomotion During Growthmentioning

confidence: 99%

Section: Emergence Of Different Modes Of Locomotion During Growthmentioning

confidence: 99%

Emergence of Different Gaits in Infancy: Relationship Between Developing Neural Circuitries and Changing Biomechanics

Dewolf

Sylos-Labini

Cappellini

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Two-month-old male C57BL mice, weighing 21–22 g, were randomly assigned to the control (Con) and groups of hindlimb unloading (HU) to partially simulate microgravity. To induce muscle unloading, the animals in the HU group were suspended individually in special cages for 14 consecutive days using a method similar to that used previously for mice 19 , 60 . Briefly, one end of a thin string was attached to the tail by sticking plaster and the other end was attached to the top of the cage.…”

Section: Methodsmentioning

confidence: 99%

“…The rotarod is used to assess the balance and motor coordination of animals 60 , 64 . Before any treatment, all animals were given three trials per day with a 5–10 min intertrial rest interval for 3 days to allow them to adapt to the task.…”

Section: Methodsmentioning

confidence: 99%

Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading

Yao

Bai

et al. 2021

Commun Biol

View full text Add to dashboard Cite

During duration spaceflight, or after their return to earth, astronauts have often suffered from gait instability and cerebellar ataxia. Here, we use a mouse model of hindlimb unloading (HU) to explore a mechanism of how reduced hindlimb burden may contribute to motor deficits. The results showed that these mice which have experienced HU for 2 weeks exhibit a rapid accumulation of formaldehyde in the gastrocnemius muscle and fastigial nucleus of cerebellum. The activation of semicarbazide-sensitive amine oxidase and sarcosine dehydrogenase induced by HU-stress contributed to formaldehyde generation and loss of the abilities to maintain balance and coordinate motor activities. Further, knockout of formaldehyde dehydrogenase (FDH-/-) in mice caused formaldehyde accumulation in the muscle and cerebellum that was associated with motor deficits. Remarkably, formaldehyde injection into the gastrocnemius muscle led to gait instability; especially, microinfusion of formaldehyde into the fastigial nucleus directly induced the same symptoms as HU-induced acute ataxia. Hence, excessive formaldehyde damages motor functions of the muscle and cerebellum.

show abstract

Effects of exercise and enrichment on behaviour in CD-1 mice

Aujnarain

Luo

Taylor

et al. 2018

Behavioural Brain Research

View full text Add to dashboard Cite

Postnatal training of 129/Sv mice confirms the long-term influence of early exercising on the motor properties of mice

Cited by 4 publications

References 45 publications

Emergence of Different Gaits in Infancy: Relationship Between Developing Neural Circuitries and Changing Biomechanics

Emergence of Different Gaits in Infancy: Relationship Between Developing Neural Circuitries and Changing Biomechanics

Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading

Effects of exercise and enrichment on behaviour in CD-1 mice

Contact Info

Product

Resources

About