2010
DOI: 10.1523/jneurosci.0238-10.2010
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Postnatal Switch from Synaptic to Extrasynaptic Transmission between Interneurons and NG2 Cells

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Cited by 95 publications
(186 citation statements)
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References 40 publications
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“…OPCs form synapses with glutamatergic neurons in all gray and white matter regions that have been examined, including the hippocampus (Bergles et al 2000;Jabs et al 2005), cerebellum (Lin et al 2005), cortex (Chittajallu et al 2004), brainstem (Muller et al 2009), and white matter tracts (Káradó ttir et al 2005;Kukley et al 2007;Ziskin et al 2007). In gray matter, they also form synapses with GABAergic neurons (Lin and Bergles 2004;Jabs et al 2005;Mangin et al 2008;Tanaka et al 2009;Velez-Fort et al 2010), suggesting that synaptic signaling is an important and highly conserved property of OPCs. Glutamatergic axon-OPC synapses are formed early in development and become more robust (larger currents, more abundant inputs) with age, paralleling the normal development of synapses that occurs in surrounding neurons, whereas GABAergic signaling in the cortex changes from synaptic to extrasynaptic with age (Velez-Fort et al 2010).…”
Section: Axoglial Synaptic Signaling and Developmentmentioning
confidence: 99%
See 1 more Smart Citation
“…OPCs form synapses with glutamatergic neurons in all gray and white matter regions that have been examined, including the hippocampus (Bergles et al 2000;Jabs et al 2005), cerebellum (Lin et al 2005), cortex (Chittajallu et al 2004), brainstem (Muller et al 2009), and white matter tracts (Káradó ttir et al 2005;Kukley et al 2007;Ziskin et al 2007). In gray matter, they also form synapses with GABAergic neurons (Lin and Bergles 2004;Jabs et al 2005;Mangin et al 2008;Tanaka et al 2009;Velez-Fort et al 2010), suggesting that synaptic signaling is an important and highly conserved property of OPCs. Glutamatergic axon-OPC synapses are formed early in development and become more robust (larger currents, more abundant inputs) with age, paralleling the normal development of synapses that occurs in surrounding neurons, whereas GABAergic signaling in the cortex changes from synaptic to extrasynaptic with age (Velez-Fort et al 2010).…”
Section: Axoglial Synaptic Signaling and Developmentmentioning
confidence: 99%
“…In gray matter, they also form synapses with GABAergic neurons (Lin and Bergles 2004;Jabs et al 2005;Mangin et al 2008;Tanaka et al 2009;Velez-Fort et al 2010), suggesting that synaptic signaling is an important and highly conserved property of OPCs. Glutamatergic axon-OPC synapses are formed early in development and become more robust (larger currents, more abundant inputs) with age, paralleling the normal development of synapses that occurs in surrounding neurons, whereas GABAergic signaling in the cortex changes from synaptic to extrasynaptic with age (Velez-Fort et al 2010). Unlike neurons, which participate in circuits as both presynaptic and postsynaptic partners, OPCs appear to be exclusively postsynaptic and receive input from neurons, rather than the reverse.…”
Section: Axoglial Synaptic Signaling and Developmentmentioning
confidence: 99%
“…Glutamate promotes formation of myelin (241,428), while GABA stimulates OPC migration (407). GABA, like glutamate, may exert its effect extrasynaptically, through volume transmission (421). Glutamate receptor-mediated inhibition of OPC proliferation (131,455) may lead to enhanced conduction velocity due to increased internodal lengths when the axons must be covered by a reduced number of oligodendrocytes.…”
Section: A Glutamate and Gabamentioning
confidence: 99%
“…Microglial serotonin receptors have also been detected (5-HT 1a , 5-HT 1f , 5-HT 2a , 5-HT 7 serotonin receptors) (203,371), along with cholinergic receptors, of which the ␣7 nicotinic type seems to be most prevalent (89, 377), while the presence of muscarinic receptors in microglia has been suggested (165). Several studies have detected effects of stimulating adrenergic receptors on cultured microglia (127,337,422).…”
Section: B Microglia Express Neurotransmitter Receptorsmentioning
confidence: 99%
“…Patch-clamp studies have identified two classes of OLP in white matter - those with synaptic input and voltage-gated Na + currents and others that have undetectable Na + currents (Karadottir et al, 2008). Some of this variation might reflect developmental stage (De Biase et al, 2010; Etxeberria et al, 2010; Kukley et al, 2010; Velez-Fort et al, 2010), although a fraction of NG2-expressing OLPs lack detectable Na + currents (Karadottir et al, 2008; Clarke et al, 2011). …”
Section: Introductionmentioning
confidence: 99%