Postnatal secretion of the subcommissural organ of the Meriones shawi: control of serotonin innervation

The rat SCO responsiveness to prolonged water deprivation: Implication of Reissner's fiber and serotonin system

“…The SCO is a target of numerous innervations [22] namely GABAergic [23,24], noradrenergic and dopaminergic [25] and serotoninergic fibers [26,27]. One of the most abundant innervating systems within the SCO is of a serotoninergic nature [28,29]. Substantial evidences have suggested that the serotoninergic system, which originates from the dorsal raphe nucleus (DRN) [30] which influence sodium appetite, food and water intake behaviors [31,32], controls the SCO secretory activity of cat, frog, lizards, and meriones [1,29,33,34].…”

The neuroactive neurosteroid Dehydroepiandrosterone Sulfate (DHEAS) modulates the serotonergic system within the dorsal Raphe nucleus and the cerebrospinal fluid release of Reissner’s fiber in rat

“…We performed an immunohistochemical assessment of serotoninergic innervation, well-known to control RF release by the different components of the SCO [34,39,41]. In saline control rats, we observed a dense and continuous plexus of 5-HTimmunoreactive fibers around the whole SCO (Figure 2A).…”

“…Previous works have shown that the SCO receives several neuronal innervations of GABAergic [35,36], noradrenergic and dopaminergic [27] and serotonergic nature [28,34,37]. The latter is the most influential system upon the secretory activity of the SCO in different mammalian species [34,[38][39][40][41]. Thereby, we aimed, throughout the present investigation, to test the possible modulator effects of the neurosteroid DHEAS on the secretory activity of the SCO in the normal rat, together with the assessment of serotonin expression in the dorsal raphe nucleus and the innervating fibers reaching the SCO in the same experimental conditions, by means of an immunohistochemical approach.…”

Microscopic anatomy of the subcommissural organ in the brain of the adult greater cane rat (Rodentia: Thryonomyidae)

“…(2022) in mouse and Laalaoui et al. (2001) in Meriones shawi , which is a desert rodent that can withstand water deprivation. The typical ependymal cells that line the third ventricle (Figure 2b,c) were distinguished, and Figure 2d demonstrated the delineation between the SCO and the conventional ependymal lining.…”