Postnatal risk factors for testicular cancer: The EPSAM case–control study

Moirano, Giovenale; Zugna, Daniela; Grasso, Chiara; Mirabelli, Dario; Lista, Patrizia; Ciuffreda, Libero; Segnan, Nereo; Merletti, Franco; Richiardi, Lorenzo

doi:10.1002/ijc.30884

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…However, not all publications support the connection between tobacco use and testicular cancer. A recent Italian study reported no apparent association between alcohol or tobacco use during adolescence (ages 13-19 years) and later diagnoses of testicular cancer (40). Maternal smoking during pregnancy may lead to elevated rates of cryptorchidism in male offspring, which is a known risk factor for the future development of testicular cancer.…”

Section: Cancer Risk Among Infertile Men Testis Cancermentioning

confidence: 98%

Male infertility: a biomarker of individual and familial cancer risk

Hanson

Eisenberg

Hotaling

2018

Fertility and Sterility

117

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Section: Cancer Risk Among Infertile Men Testis Cancermentioning

confidence: 98%

Male infertility: a biomarker of individual and familial cancer risk

Hanson

Eisenberg

Hotaling

2018

Fertility and Sterility

117

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“…The relative risk of TGCT was 2.23 even if patients underwent orchiopexy before 13 years old (27). Moirano et al (28) observed that undescended testis was higher in TGCT group (11.4%) than in healthy control group (3.0%). Hanson et al (29) detected an increased risk of testicular cancer (hazard rate of 3.3) in subfertile men when compared with fertile men (29).…”

Section: Discussionmentioning

confidence: 98%

Effects of testicular dysgenesis syndrome components on testicular germ cell tumor prognosis and oncological outcomes

et al. 2020

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Purpose: To evaluate whether components of Testicular Dysgenesis Syndrome (TDS) affect testicular germ cell tumor (TGCT) prognosis and oncological outcomes. According to the hypothesis called TDS; undescended testis, hypospadias, testicular cancer and spermatogenic disorders share the same risk factors and have a combined fetal origin. Materials and Methods: We retrospectively evaluated the stages and oncological outcomes of 69 patients who underwent radical orchiectomy between January 2010 and December 2014 due to TGCT in our department. The presence of undescended testis, hypospadias and semen parameters disorders were recorded according to anamnesis of patients. Results: Among 69 patients with TGCT, only 16 (23.1%) had TDS. Significantly higher rate of TDS (36.1% vs. 9.1%) was observed at the advanced stages of TGCT(p=0.008). In the TDS group, the rates of local recurrence (50% vs. 11.3%, p<0.001), distant metastasis (93.6% vs. 3.8%, p<0.001) and cancer-spesific mortality (87.5% vs. 3.8%, p<0.001) were found significantly higher than those without TDS. The predicted time for recurrence-free survival (13.70±5.13 vs. 100.96±2.83 months, p<0.001) metastasis-free survival (13.12±4.21 vs. 102.79±2.21 months, p <0.001) and cancer-specific survival (13.68±5.38 vs. 102.80±2.19 months, p<0.001) were also statistically lower in this group. Conclusions: According to our preliminary results, there is an apparent relationship between TDS and tumor prognosis. Even if the components of TDS alone did not contain poor prognostic features for TGCT, the presence of TDS was found as the most important independent predictive factor for oncological outcomes in both seminomas and nonseminomas as well as all patients with TGCT.

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“…The study population has been previously described [ 23 , 24 ]. Between 2008 and 2010, a population-based case-control study was conducted among testicular cancer patients diagnosed in the Province of Turin, Italy, between 1997 and 2008.…”

Section: Methodsmentioning

confidence: 99%

Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis

et al. 2021

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Introduction Testicular cancer is one of the most treatable cancers, with a 10-year survival of more than 95%. Many patients will be long-term survivors and this disease strikes men in an important phase of their lives, therefore the quality of life (QoL) among these patients is an area of particular interest. We aimed to study whether QoL in testicular cancer survivors depends on the time since cancer diagnosis. Methods Data were collected from the EPSAM (Esposizioni postnatali e salute maschile) study, a case-control study on patients with testicular cancer, diagnosed between 1997 and 2008 in the province of Turin, Northern Italy, and interviewed between 2008 and 2010 (response rate among cases 57%). Patients were contacted through their oncologist at the San Giovanni Batista Hospital in Turin or through their general practitioner (GP) in the rest of the Province of Turin. QoL was assessed cross-sectionally using the short form 12 (SF-12) questionnaire, a generic short-form health survey that produces two summary scores, PCS (physical component score) and MCS (mental component score), to evaluate physical and mental health, respectively. Results Out of 234 study patients, 125 cases were seminomas and 109 cases were nonseminomas. The mean age at diagnosis was 34.5 years. After adjusting for age, time since diagnosis was not associated with PCS and MCS scores. Among nonseminomas, the median PCS slightly increased (adjusted OR (odds ratio) for 5+ vs < 2 years since cancer diagnosis: 1.78 (1.17–2.73), p = 0.008) and MCS slightly decreased (adjusted OR per 1-year increase since cancer diagnosis: 0.92, 95% CI: 0.82–1.05, p = 0.23) with time. Similar findings of no association between time since diagnosis and PCS and MCS were found when the analyses were restricted to the subgroup of cancer patients contacted through their oncologist, whose response proportion was 82%. Conclusion In a study of testicular cancer patients interviewed cross-sectionally at 1 to more than 10 years since diagnosis, time since cancer diagnosis was not associated with QoL when we considered all germ-cell testicular cancer patients together. When stratified by histology type, we found certain evidence that nonseminoma cases report higher PCS over time since cancer diagnosis.

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Postnatal risk factors for testicular cancer: The EPSAM case–control study

Cited by 10 publications

References 39 publications

Male infertility: a biomarker of individual and familial cancer risk

Male infertility: a biomarker of individual and familial cancer risk

Effects of testicular dysgenesis syndrome components on testicular germ cell tumor prognosis and oncological outcomes

Quality of life among germ-cell testicular cancer survivors: The effect of time since cancer diagnosis

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