Postnatal maturation of the gastrointestinal tract: A functional and immunohistochemical study in the guinea-pig ileum at weaning

Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat

“…Interestingly, temporal differences in the action of both drugs do exist 10,14 and the mechanisms of action underlying gastric dysmotility are also different. Whereas cannabinoid agonists inhibit the release of excitatory neurotransmitters, such as acetylcholine, [37][38][39][40][41] leading to depressed GI motility, [13][14][15][16] cisplatin stimulates serotonin release from the intestinal enterochromaffin cells. In addition, antitumoral treatment produces free radicals in the small intestine, 42 which may further induce the release of serotonin.…”

Contractility of isolated colonic smooth muscle strips from rats treated with cancer chemotherapy: differential effects of cisplatin and vincristine

“…Since the response to KCl normalized to weight and the responses to ACh in each muscle were comparable in both cohorts, it is difficult to explain these differences between the control groups used in these cohorts, unless the difference in body weight/age (maturity) of the animals might have an influence in colonic innervation. Studies in aged animals ( Wade, 2002 ; Abalo et al, 2005a , 2007 ; Phillips and Powley, 2007 ; Fidalgo et al, 2018 ) and humans ( Broad et al, 2019 ) show clear differences in functional responses and numbers of myenteric neurons and glial cells, whereas studies in immature and mature animals only show subtle differences ( Abalo et al, 2009 ). However, as our cohorts differ by only 3 weeks, all being young adults at the start of the experiment, the observed differences may be, more likely, due to the different handling of the animals prior to sacrifice (namely, one weekly vs. one daily injection in cohort 1 vs. cohort 2).…”