Postnatal mammary gland morphogenesis

Silberstein, Gary B.

doi:10.1002/1097-0029(20010115)52:2<155::aid-jemt1001>3.0.co;2-p

Cited by 160 publications

(112 citation statements)

References 59 publications

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“…TEBs are sites for proliferation and penetration of the advancing duct into the fat pad at puberty, and they normally regress once the nascent ducts have traversed the mammary fat pad (25). A typical TEB is a bulbous structure at the end of the duct consisting of an outer monolayer of cap cells at the advancing edge that gives rise distally to the myoepithelium surrounding the duct, and an inner compartment of prelumenal and luminal body cells that line the duct (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A typical TEB is a bulbous structure at the end of the duct consisting of an outer monolayer of cap cells at the advancing edge that gives rise distally to the myoepithelium surrounding the duct, and an inner compartment of prelumenal and luminal body cells that line the duct (Fig. 4 a and c) (25,26). In contrast, the ErbB2 Ϫ/Ϫ TEBs, although similar in number to the ErbB2 ϩ/ϩ TEBs, seem to have a normal cap cell͞myoepithelial cell layer, but the body cell layer often seems loosely packed, with large spaces, and severely diminished cell number (Figs.…”

Section: Resultsmentioning

confidence: 99%

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ErbB2 is required for ductal morphogenesis of the mammary gland

Jackson-Fisher

Bellinger

Ramabhadran

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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The ERBB2͞HER2͞NEU receptor tyrosine kinase gene is amplified in up to 30% of human breast cancers. The frequent and specific selection of this receptor kinase gene for amplification in breast cancer implies that it has important normal functions in the mammary gland. To investigate the functions of ErbB2 during normal mouse mammary gland development, we transplanted mammary buds from genetically rescued ErbB2 ؊/؊ embryos that express ErbB2 in the cardiac muscle. ErbB2 ؊/؊ mammary buds transplanted to a wild-type mammary fat pad support outgrowth of an epithelial tree that advances only slowly through the mammary fat pad at puberty. This penetration defect is associated with structural defects in terminal end buds, characterized by a decrease in body cell number, an increased presence of cap-like cells in the prelumenal compartment, and the presence of large luminal spaces. Lobuloalveolar development was not affected in glands that developed from ErbB2 ؊/؊ transplanted tissue. The results may have implications for the aggressive phenotypes associated with ERBB2-overexpressing mammary carcinomas.development ͉ terminal end bud ͉ HER2 ͉ EGF

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

ErbB2 is required for ductal morphogenesis of the mammary gland

Jackson-Fisher

Bellinger

Ramabhadran

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…TEBs consist of an outer layer of "cap" cells, which eventually form myoepithelial cells, and an inner layer of "body" cells, which become the luminal cell compartment ( Figure 1B). The TEBs lead the growth of the gland until they reach the end of the fat pad, at which point they disappear [2]. The rest of the space in post-pubertal mammary gland is taken up by adipose tissue, along with a mixture of blood vessels, immune cells and fibroblasts [3].…”

Section: Biology Of the Mammary Glandmentioning

confidence: 99%

From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer

Tiede

Kang

2011

Cell Res

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Adult stem cells of the mammary gland (MaSCs) are a highly dynamic population of cells that are responsible for the generation of the gland during puberty and its expansion during pregnancy. In recent years significant advances have been made in understanding how these cells are regulated during these developmentally important processes both in humans and in mice. Understanding how MaSCs are regulated is becoming a particularly important area of research, given that they may be particularly susceptible targets for transformation in breast cancer. Here, we summarize the identification of MaSCs, how they are regulated and the evidence for their serving as the origins of breast cancer. In particular, we focus on how changes in MaSC populations may explain both the increased risk of developing aggressive ER/PR(−) breast cancer shortly after pregnancy and the long-term decreased risk of developing ER/ PR(+) tumors.

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“…These cells are arranged in two circular layers and form a tube-within-a-tube. The innermost cells line the lumen, forming the ductal or acinar tube proper, and give rise to secretory structures at pregnancy, while the myoepithelium forms the epithelial boundary with the stroma and is comprised of contractile cells that facilitate milk extrusion (Silberstein, 2001).…”

Section: Expression Of Pax2 In the Normal And Cancerous Human Breastmentioning

confidence: 99%

Expression of the PAX2 oncogene in human breast cancer and its role in progesterone-dependent mammary growth

2002

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In this study, we ®rst describe expression of the paired domain transcription factor PAX2 in the normal and cancerous human breast, then demonstrate in a murine model a novel function for PAX2 in the regulation of progesterone stimulation of secondary ductal growth. In human mammary tissue, PAX2 expression was coincident with sub-populations of mammary ductal cells, some of which possessed an undi erentiated histiotype, and was also found in 450% of the human breast tumors surveyed (n=38). In the mouse, mammary parenchyma with a targeted deletion of PAX2 developed normal ductal systems when grafted into wild-type host mammary fat pads, but failed to undergo higher order side-branching and lobular development in response to progesterone. A previously unsuspected PAX2/WT1 (Wilms' tumor suppressor gene) regulatory axis in the mammary gland was also indicated. Using RT ± PCR, a signi®cant reduction in WT1 mRNA expression was detected in the PAX2 mutant glands compared to wildtype counterparts and double-antibody immunohistochemistry detected the co-localization of PAX2 and WT1 in the nuclei of normal and cancerous breast cells. These data indicate a role for PAX2 (and possibly WT1) in the regulation of the progesterone response of the mature mammary gland. The potential contribution of PAX2 to breast tumor pathogenesis is discussed.

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Postnatal mammary gland morphogenesis

Cited by 160 publications

References 59 publications

ErbB2 is required for ductal morphogenesis of the mammary gland

ErbB2 is required for ductal morphogenesis of the mammary gland

From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer

Expression of the PAX2 oncogene in human breast cancer and its role in progesterone-dependent mammary growth

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