Postnatal Lipopolysaccharide-Induced Illness Predisposes to Periodontal Disease in Adulthood

Breivik, Torbjørn; Stephan, Michael; Brabant, Georg; Straub, Rainer H.; Pabst, Reinhard; Hörsten, Stephan von

doi:10.1006/brbi.2001.0642

Cited by 88 publications

(97 citation statements)

References 39 publications

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“…However, at least one of these studies used the hypersensitive Fischer 344 rat (Walker et al, 2004), indicating a possible strain difference on behavioral consequences of neonatal LPS exposure. Also, in each of these studies, the LPS was delivered at earlier time points P3 and/or P5 (Walker et al, 2004;Breivik et al, 2002;Anseloni et al, 2005). It is possible that a significant effect on behavior could be seen with an early-life LPS challenge at a different time point to those tested here, or that a different behavioral test would be more suitable for identifying differences.…”

Section: Lps Does Not Significantly Alter Adult Behavior In the Elevamentioning

confidence: 99%

“…One major factor in this may be the timing of the early challenge. We have previously shown that LPS given at P14 does not affect basal exploration of the elevated plus maze, an assessment of activity and anxiety; however, two studies which involved an endotoxin exposure at earlier time points have demonstrated effects on plus maze responses in adults (Breivik et al, 2002;Walker et al, 2004). Thus, we also assessed activity and anxiety responses in the elevated plus maze.…”

Section: Introductionmentioning

confidence: 97%

“…Early-life manipulations such as a neuroimmune challenge have been shown in some studies to affect activity and anxiety responses to mildly stressful situations in adulthood; however, there are some discrepancies between the findings (Walker et al, 2004;Breivik et al, 2002;Spencer et al, 2005). One major factor in this may be the timing of the early challenge.…”

Section: Introductionmentioning

confidence: 99%

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Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Spencer

Martin

Mouihate

et al. 2006

Neuropsychopharmacol

100

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Many aspects of mammalian physiology are functionally immature at birth and continue to develop throughout at least the first few weeks of life. Animals are therefore vulnerable during this time to environmental influences such as stress and challenges to the immune system that may permanently affect adult function. The adult immune system is uniquely sensitive to immune challenges encountered during the neonatal period, but it is unknown where the critical window for this programming lies. We subjected male Sprague-Dawley rats at postnatal day (P)7, P14, P21, and P28 to either a saline or lipopolysaccharide (LPS) injection and examined them in adulthood for differences in responses to a further LPS injection. Adult febrile and cyclooxygenase-2 responses to LPS were attenuated in rats given LPS at P14 and P21, but not in those treated at P7 or P28, while P7-LPS rats displayed lower adult body weights than those treated at other times. P28-LPS rats also tended to display enhanced anxiety in the elevated plus maze. In further experiments, we examined maternal-pup interactions, looking at the mothers' preference in two pup-retrieval tasks, and found no differences in maternal attention to LPS-treated pups. We therefore demonstrate a 'critical window' for the effects of a neonatal immune challenge on adult febrile responses to inflammation and suggest that there are other critical time points during development for the programming of adult physiology. We also show that the neonatal LPS effects on the adult immune system are not likely due to overt differences in maternal attention.

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Section: Lps Does Not Significantly Alter Adult Behavior In the Elevamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Spencer

Martin

Mouihate

et al. 2006

Neuropsychopharmacol

100

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“…For monitoring home cage activity, an infrared sensor controlled recording system (model No. E61-01/08; Coulbourn Instruments, Allentown, PA, USA) was used as described previously (23). This test is based on infrared detection of number and time of movements and it is useful to screen for differences in circadian rhythm.…”

Section: Determination Of Motor Functions (Accelerod Test) and Circadmentioning

confidence: 99%

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions

Frerker

Raber²,

Bode³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…show that the chemical modulation of the HPA axis, or directly the effect of physical chronic stress during pregnancy are responsible for a higher progression of periodontitis induced in adulthood 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Effect of chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood

et al. 2013

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PURPOSE:To investigate the effect chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood. METHODS:Ten couples of adult Wistar rats were selected for mating. After birth, the female and their respective offsprings were allocated into two groups. Ligature Group (LG): offsprings were only watched during breast-feeding; Stress-ligature Group (SLG): after 24h of live birth, the offsprings were moved away from their mothers every day for four hours during breast-feeding for 20 days; in both approaches, after reaching ± 250g, ten rats were included in the groups. Periodontal disease was induced by a silk suture placed around the maxillary right second molar. The left side was used as control. After 15 days, the animals were subjected to euthanasia, maxillary bones were removed and stored in 10% formaldehyde. After 48h, radiographs were taken and revealed and were used for bone destruction analysis. Examiner was blind and calibrated for measurements. RESULTS:Stress-ligature group presented higher bone loss values in relation to ligature group (p<0.05). CONCLUSION:Exposure to chronic stress imposed on offsprings produced a greater progression of bone loss induced during adulthood.

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Postnatal Lipopolysaccharide-Induced Illness Predisposes to Periodontal Disease in Adulthood

Cited by 88 publications

References 39 publications

Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions

Effect of chronic stress in newborn rats on the progression of ligature-induced-periodontitis in adulthood

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