Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome

Latal-Hajnal, B.; Siebenthal, Kurt von; Kovari, Helen; Bucher, Hans Ulrich; Largo, R. H.

doi:10.1067/s0022-3476(03)00243-9

Cited by 351 publications

(231 citation statements)

References 31 publications

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“…At present, it is unclear whether interventions aimed at discouraging infancy weight gain would improve adult body composition and reduce the chance of developing type 2 diabetes. However, recent evidence suggests that rapid infancy weight gain of very preterm infants is beneficial for several neurodevelopmental outcomes [37,38], making intervention (i.e. undernutrition) hard to justify.…”

Section: Discussionmentioning

confidence: 99%

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

et al. 2006

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Aims/hypothesis: An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not provided follow-up into adulthood. We studied the effects of (1) lower birthweight (as standard deviation score [SDS]) and infancy weight gain on insulin resistance in 19-year-olds born before 32 weeks of gestation, and (2) the interaction be-

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Section: Discussionmentioning

confidence: 99%

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

et al. 2006

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“…This "fetal origin of adult diseases" hypothesis proposes that an impaired intrauterine environment (e.g., deficient in nutrients, oxygen, hormones, or enriched in toxics), leading to abnormal fetal growth and altered tissue development programs the fetus for later chronic diseases in adulthood (2). Although cerebral structures are more preserved than other tissues during deleterious conditions of growth (brain sparing effect), IUGR also compromises brain development and increases the risk for later mental and psychomotor developmental complications, in particular in infants not showing catch-up growth (3). The hippocampus appears to be especially susceptible to the effects of IUGR, as well as in animal models (4) as in the human situation (5).…”

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confidence: 99%

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

et al. 2013

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Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf ) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. Methods: IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pups growth was monitored, and pup brain metabolism and gene expression were studied using in vivo 1 H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7. results: Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pup (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation. conclusion: Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.

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“…EUGR has been associated with low MDI, low PDI) and low intelligence quotient at school age, behavioral problems, poor attention and poor receptive language scores. 18,31 In addition EUGR in the neonatal period is associated with short stature into adulthood, and poor head growth. 18 Given these long-term risks of EUGR, it is important to identify early predictors of EUGR so that Pulmonary morbidities significantly decreased in the post-EMPC cohort.…”

Section: Discussionmentioning

confidence: 99%

“…18,31 In addition EUGR in the neonatal period is associated with short stature into adulthood, and poor head growth. 18 Given these long-term risks of EUGR, it is important to identify early predictors of EUGR so that Pulmonary morbidities significantly decreased in the post-EMPC cohort. This data are presented extensively in a separate article.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17] The ultimate goal of these three interventions is to improve short-and long-term outcomes. Our primary outcome measure was growth, as EUGR is associated with significantly lower Bayley Mental Development Index (MDI) and Psychomotor Index (PDI) scores at 2 years of age, 18 and impaired long-term growth potential. 19,20 We also assessed other morbidities associated with long-term complications as an indicator of whether a net benefit was achieved with these three interventions.…”

Section: Introductionmentioning

confidence: 99%

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Improved growth and decreased morbidities in <1000 g neonates after early management changes

et al. 2008

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Objective: To test the hypothesis that three changes in the early management of extremely low birth weight (ELBW) neonates would decrease the incidence of extra-uterine growth restriction (EUGR) by 25%. The three early management practice changes (EMPC) included surfactant at delivery followed by immediate extubation to nasal continuous positive airway pressure (CPAP), decreased oxygen exposure and early parenteral amino acids.

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Postnatal growth in VLBW infants: significant association with neurodevelopmental outcome

Cited by 351 publications

References 31 publications

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Improved growth and decreased morbidities in <1000 g neonates after early management changes

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