Postnatal growth in preterm infants and later health outcomes: a systematic review

Ong, Ken K.; Kennedy, Kathy; Castañeda-Gutiérrez, Eurídice; Forsyth, Stewart; Godfrey, Keith M.; Koletzko, Berthold; Latulippe, Marie E.; Ozanne, Susan E.; Rueda, Ricardo; Schoemaker, Marieke H.; Beek, Eline M. van der; Buuren, Stef van; Fewtrell, Mary

doi:10.1111/apa.13128

Cited by 244 publications

(219 citation statements)

References 63 publications

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“…Other stakeholders have been specifically addressed with targeted communication. Evidence-based recommendations on optimized practice of nutrition before and during pregnancy, during the breast feeding period and the early life of infants, have been developed based on the project results and on systematic reviews of available evidence [35,36,37,38,39,40,41,42], in close collaboration with a broad group of stakeholders (prepared for publication). These recommendations are of considerable importance because most of the current guidance for pregnant women, particularly obese women, and for young children does not take into account the long-term programming consequences of early nutrition.…”

Section: Further Disseminationmentioning

confidence: 99%

Long-Term Health Impact of Early Nutrition: The Power of Programming

Koletzko

Brands²,

Grote³

et al. 2017

Ann Nutr Metab

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103

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The Power of Programming conference 2016 at Ludwig-Maximilians-Universität Munich brought together about 600 researchers and other stakeholders from around the world who reviewed the recent evidence on the lasting health impact of environment and nutrition during early life, from pre-pregnancy to early childhood. The conference was hosted by the Early Nutrition Project, a multidisciplinary research collaboration funded by the European Commission with collaborating researchers from 35 institutions in 15 countries in Europe, the United States and Australia. The project explores the early origins of obesity, adiposity and associated non-communicable diseases, underlying mechanisms and opportunities for prevention. The project also proactively supports translational application of research findings. In fact, some existing evidence has already been rapidly adopted into policy, regulatory standards and practice. Further, broad dissemination of findings is achieved through the established digital eLearning platform of the Early Nutrition eAcademy, video clip-based learning and graphically supported messaging to consumers. The project demonstrated powerful effects of early metabolic programming on later health. Compared to other common prevention strategies, modifying risk trajectories in early life can achieve a much larger risk reduction and be more cost-effective. While some effective prevention strategies have been promptly implemented in policy and guidelines, legislation and practice, in other areas, the uptake is limited by a paucity of quality human intervention trials and insufficient evaluation of the feasibility of implementation and econometric impact. This needs to be strengthened by future collaborative research work.

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Section: Further Disseminationmentioning

confidence: 99%

Long-Term Health Impact of Early Nutrition: The Power of Programming

Koletzko

Brands²,

Grote³

et al. 2017

Ann Nutr Metab

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103

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“…There is no doubt that this approach substantially reduces the extent of postnatal growth restriction (27,28) and, as a consequence, the need for catch-up. Altogether, this emphasizes the importance of an adequate early nutritional supply to accomplish adequate postnatal growth and healthy neurocognitive and metabolic development (29). Third, because the differences at 6-mo CA were small, the children's diet and their individual lifestyles after the intervention might have attenuated the potential benefits of PDF.…”

Section: Discussionmentioning

confidence: 99%

Follow-up of a randomized trial on postdischarge nutrition in preterm-born children at age 8 y

Ruys¹,

Lagemaat²,

Finken

et al. 2017

The American Journal of Clinical Nutrition

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Background: Early nutritional interventions may modulate health risks in preterm-born infants. Previously, we showed that pretermborn infants fed an isocaloric protein-and mineral-enriched postdischarge formula (PDF) from term age to 6-mo corrected age (CA) gained more lean mass than did those fed term formula (TF). Longterm follow-up of randomized nutritional trials is important to test the hypothesis that short-term positive effects on health are sustainable. Objective: The aim of this follow-up study was to compare body size, body composition, and metabolic health at age 8 y in pretermborn children who were randomly assigned to receive either PDF or TF from term age until 6-mo CA. Design: A total of 79 of 152 children (52%) from the original randomized controlled trial were enrolled for follow-up at age 8 y. Weight, height, and head circumference were measured by using standard methods. Body composition, including fat mass, lean mass, bone mineral content, and bone mineral density, was determined by dual-energy X-ray absorptiometry. Blood pressure was measured in the supine position by using an automatic device. Metabolic variables, including glucose, insulin, insulin-like growth factor I, triglycerides, cholesterol, cortisol, and leptin, were measured after an overnight fast. Nutritional habits at age 8 y were assessed by using a 3-d nutritional diary. Results: At age 8 y, no differences were found in body size, body composition, bone variables, and metabolic health variables when comparing children fed PDF with those fed TF. Adjustment for known and possible confounders did not change these results. Conclusions: In this follow-up study in preterm-born children, we showed that the favorable effects of PDF at 6-mo CA either were not maintained or could not be confirmed because of attrition at the age of 8 y. We suggest that future research should focus on nutritional interventions in the pre-and postdischarge period as a continuum rather than as separate entities. This trial was registered at www.trialregister.nl as NTR 2972 (follow-up study [STEP-2 (Study Towards the Effects of Post-discharge Nutrition 2)]) and NTR 55 [original randomized controlled trial (STEP)].Am J Clin Nutr 2017;106:549-58.

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“…Methods. 12-14 and 16-18 397 (3,096;3,608) and with 824 (3,797;3,899) was lower than in infants with 497 (4,034;4,511 (3,887;4,647) p = 0.048 …”

mentioning

confidence: 85%

“…В последние годы придается большое значение изучению нутритивного статуса ребенка первого года жизни и его взаимосвязи с формирующимся состоя-нием здоровья [1][2][3].…”

Section: обоснованиеunclassified

Nutritional Status, Physical and Psychomotor Development of Premature Infants: A Prospective Observational Comparative Study

Турти¹,

Горбачёва²,

Лукоянова³

2018

Pediatr. farmakol.

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Развитие недоношенных детей происходит медленнее, чем у детей, родившихся в срок, часто по причине откло-нений в нутритивном статусе недоношенных. Цель исследования -изучить состояние нутритивного статуса, физического и психомоторного развития детей первого года жизни. Методы. Нутритивный статус -состав (соот-ношение жировых и безжировых тканей) и значение безжировой массы тела (БЖМТ) -оценивали методами пле-тизмографии и денситометрии; физическое развитие -путем измерения массы и длины тела, окружности головы и груди, расчета индекса массы тела (ИМТ); психомоторное развитие -оценивая соответствие графику нервно-психического развития младенцев (ГНОМ ЭНМТ -3397 (3096; 3608) и ОНМТ -3824 (3797; 3899) была ниже, чем у детей с НМТ -4497 (4034; 4651) и доношенных -4511 (3887; 4647) (тест Краскела-Уоллиса, р=0,048 Под нутритивным статусом мы понимаем состоя-ние организма, его структуры (соотношение мышеч-ной и жировой массы тела) и функций, сложившееся под влиянием количественных и качественных осо-бенностей фактического питания. Особенно актуальной эта проблема является для детей, родившихся недоно-шенными, с тяжелой перинатальной патологией [4,5]. Именно эта категория пациентов может быть на протя-жении длительного периода времени ограничена в полу-чении и усвоении энтерального питания с развитием белково-энергетической недостаточности, что приводит к необходимости продолжительного этапного выхажи-вания [6,7]. Имеются данные, что несбалансированное 51Background. The development of premature infants is slower than that of term ones, often due to nutritional status disorders in preterm infants. Objective. Our aim was to study the nutritional status, physical, and psychomotor development of infants. Methods. 12-14 and 16-18 397 (3,096;3,608) and with 824 (3,797;3,899) was lower than in infants with 497 (4,034;4,511 (3,887;4,647) p = 0.048 Nutritional status -the composition (the ratio of fat and fat-free tissues) and the value of lean body mass (LBM) -was assessed by plethysmography and densitometry; physical development -by measuring the mass and length of the body, the circumference of the head and chest, calculating the body mass index (BMI); psychomotor development -assessing compliance with the schedule of neuropsychological development of infants (GNOM). The examination was carried out at

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Postnatal growth in preterm infants and later health outcomes: a systematic review

Cited by 244 publications

References 63 publications

Long-Term Health Impact of Early Nutrition: The Power of Programming

Long-Term Health Impact of Early Nutrition: The Power of Programming

Follow-up of a randomized trial on postdischarge nutrition in preterm-born children at age 8 y

Nutritional Status, Physical and Psychomotor Development of Premature Infants: A Prospective Observational Comparative Study

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