Postnatal exposure to octylphenol decreases semen quality in the adult ram

Sweeney, T.; Fox, Janis H.; Robertson, Lindsay; Kelly, G. Lombard; Duffy, Patrick E.; Lonergan, P.; O’Doherty, John V.; Roche, J. F.; Evans, Neil P.

doi:10.1016/j.theriogenology.2006.12.010

Cited by 18 publications

(11 citation statements)

References 43 publications

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“…Maternal exposure of dams to OP from Day 70 of gestation until birth resulted in decreased testicular weight and a reduction in Sertoli cell number at birth (Sweeney et al 2000), but an equivalent exposure did not affect semen quantity, quality or IVM or IVF characteristics at 12 months of age (Sweeney et al 2007). In contrast, when males were exposed to OP from birth to weaning (but not from Day 70 of gestation to weaning), the number of morphologically abnormal spermatozoa was increased by 12% (Sweeney et al 2007). The effect of this small increase in the proportion of abnormal spermatozoa on ram fertility in field conditions is unknown.…”

Section: Effects Of Edcs On Testicular Functionmentioning

confidence: 92%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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Section: Effects Of Edcs On Testicular Functionmentioning

confidence: 92%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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“…For example, it has been widely documented that foetal and post-natal exposure to oestrogens or oestrogen-like substances, that mimic endogenous oestrogens, cause adverse effects in male sexual differentiation (Refs 123, 124) and reproductive potential of the adult ( Refs 125,126,127). Noteworthy are the elevated concentrations of E 2 ( Refs 128,137).…”

Section: Experimental and Clinical Evidence Of Oestrogens Damaging Efmentioning

confidence: 99%

Oestrogens as apoptosis regulators in mammalian testis: angels or devils?

Correia

Cardoso

Cavaco

et al. 2015

Expert Rev. Mol. Med.

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In the mammalian testis, spermatogenesis is a highly coordinated process of germ cell development, which ends with the release of 'mature' spermatozoa. The fine regulation of spermatogenesis is strictly dependent on sex steroid hormones, which orchestrate the cellular and molecular events underlying normal development of germ cells. Sex steroids actions also rely on the control of germ cell survival, and the programmed cell death by apoptosis has been indicated as a critical process in regulating the size and quality of the germ line. Recently, oestrogens have emerged as important regulators of germ cell fate. However, the beneficial or detrimental effects of oestrogens in spermatogenesis are controversial, with independent reports arguing for their role as cell survival factors or as apoptosis-inducers. The dual behaviour of oestrogens, shifting from 'angels to devils' is supported by the clinical findings of increased oestrogens levels in serum and intratesticular milieu of idiopathic infertile men. This review aims to discuss the available information concerning the role of oestrogens in the control of germ cell death and summarises the signalling mechanisms driven oestrogen-induced apoptosis. The present data represent a valuable basis for the clinical management of hyperoestrogenism-related infertility and provide a rationale for the use of oestrogen-target therapies in male infertility.

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“…By contrast, a substantial amount of data also has ascribed the deleterious effects of estrogens and estrogen-like substances for male reproductive function. Abnormal exposure to estrogens has been shown to affect male sexual differentiation (Sultan et al, 2001;Toppari, 2002) and the spermatogenic output (Sweeney, 2002;Sweeney et al, 2007). In an attempt to investigate the regulatory factors controlling the expression of SCF during spermatogenesis, Yan and co-authors firstly investigated the effect of estrogens on the testicular expression of SCF/c-KIT system.…”

Section: Estrogensmentioning

confidence: 99%