Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets

Karege, Félicien; Schwald, Michèle; Cisse, Mbaye

doi:10.1016/s0304-3940(02)00529-3

Cited by 723 publications

(446 citation statements)

References 17 publications

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“…As platelets and neurons develop from a common embryonic precursor in the neural crest (Pearse, 1980), the peripheral BDNF concentration could possibly reflect the central neurotransmission state. A parallel BDNF brain and serum situation is underlined by the finding of Karege et al (2002b), who reported a positive correlation between the brain and serum BDNF levels in rats, which underwent similar changes during maturation and aging processes.…”

Section: Discussionmentioning

confidence: 88%

BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

Lang

Hellweg

Gallinat

2004

Neuropsychopharmacol

196

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The issue of neurotrophins is recognized as a new lead in the quest for a deeper understanding of mood disorders. This hypothesis has emerged from experimental evidence suggesting that antidepressant drugs might work by a neuroprotective effect through the stimulation of the neurotrophin expression in distinct regions of the CNS. Endogenous levels of BDNF protein were measured in the serum samples of 118 healthy unrelated volunteers (64 male, 54 female, age: 42.1713.0 years), and the NEO-FFI has been performed in all subjects. BDNF serum values amounted to 16.377.3 ng/ml. BDNF concentration correlated significantly with age (r ¼ 0.182, p ¼ 0.048), but showed no gender differences (male 16.177.2, female 16.577.4 ng/ml). A negative correlation between the BDNF serum concentration and the depression-related factor neuroticism (r ¼ À0.212, p ¼ 0.022) has been found. Low BDNF levels in healthy humans with depressive personality traits might constitute a risk marker, reflecting a personality profilethat is linked to vulnerability to mood disorders. These results provide further support for the hypothesis that BDNF may be central to the development of depressive mood states.

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“…As platelets and neurons develop from a common embryonic precursor in the neural crest (Pearse, 1980), the peripheral BDNF concentration could possibly reflect the central neurotransmission state. A parallel BDNF brain and serum situation is underlined by the finding of Karege et al (2002b), who reported a positive correlation between the brain and serum BDNF levels in rats, which underwent similar changes during maturation and aging processes.…”

Section: Discussionmentioning

confidence: 88%

BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

Lang

Hellweg

Gallinat

2004

Neuropsychopharmacol

196

View full text Add to dashboard Cite

show abstract

“…As platelets and neurons develop from a common embryonic precursor in the neural crest (Pearse, 1980), the peripheral BDNF concentration could possibly reflect the central neurotransmission state as it was stated also for serotonergic neurotransmission in platelets (Lesch et al, 1993). A parallel BDNF brain and serum situation is underlined by the finding of Karege et al (2002), who reported a positive correlation between brain and serum BDNF levels in rats, which underwent similar changes during maturation and aging processes and data showing neurotrophic factors from the blood stream can cross the blood-brain barrier under experimental conditions (Pan et al, 1998). However there are also conflicting results, showing that neurotrophins do not cross the blood-brain barrier (Pardridge, 2002).…”

Section: Discussionmentioning

confidence: 91%

Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Lang

Hellweg

Gallinat

2005

Neuropsychopharmacol

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Disturbances of serotonergic neurotransmission in the brain have been implicated in the pathogenesis and maintenance of several psychiatric disorders. According to recent preclinical and clinical studies, the loudness dependence of auditory evoked potentials (LD) is related to the central serotonergic neurotransmission in humans. As the serotonergic phenotype has been reported to be associated with brain-derived neurotrophic factor (BDNF), we studied whether BDNF serum concentrations are related to LD in 109 healthy human volunteers (62 male, 47 female, age: 42.5713.1 years). Pearson correlation showed a significant negative correlation between the BDNF serum concentrations and the LD measured at Fz (r ¼ À0.259, p ¼ 0.007) and a trend for the Cz electrode (r ¼ À0.185, p ¼ 0.055). Although this association needs to be replicated, the results are in line with the assumption that low serum BDNF levels reflect low central serotonergic neurotransmission as indicated by a strong LD.

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“…BDNF is trophic for serotonergic neurons, and abnormalities in serotonin levels are the most common biochemical findings in autism [Anderson, 2002;Tsai, 2005]. Animal studies suggest that concentrations of BDNF in the CNS and serum are closely correlated [Karege, Schwald, & Cisse, 2002], offering the possibility that concentrations in peripheral blood may be useful as a possible biologic marker for autism.…”

Section: Introductionmentioning

confidence: 99%

Brain‐derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study

et al. 2008

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To investigate levels of brain-derived neurotrophic factor (BDNF) in mid-pregnancy and neonatal blood specimens as early biologic markers for autism, we conducted a population-based case-control study nested within the cohort of infants born from July 2000 to September 2001 to women who participated in the prenatal screening program in Orange County, CA. Cases (n 5 84) were all children receiving services for autism at the Regional Center of Orange County. Two comparison groups from the same study population were included: children with mental retardation or developmental delay (n 5 49) receiving services at the same regional center, and children not receiving services for developmental disabilities, randomly sampled from the California birth certificate files (n 5 159), and frequency matched to autism cases on sex, birth year, and birth month. BDNF concentrations were measured in archived mid-pregnancy and neonatal blood specimens drawn during routine prenatal and newborn screening using a highly sensitive bead-based assay (Luminex, Biosource Human BDNF Antibody Bead Kit, Invitrogen-Biosource, Carlsbad, CA). The concentration of BDNF in maternal mid-pregnancy and neonatal specimens was similar across all three study groups. These data do not support previous findings of an association between BDNF and autism and suggest that the concentration of BDNF during critical periods of early neurodevelopment is not likely to be a useful biomarker for autism susceptibility.

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Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets

Cited by 723 publications

References 17 publications

BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

BDNF Serum Concentrations in Healthy Volunteers are Associated with Depression-Related Personality Traits

Association of BDNF Serum Concentrations with Central Serotonergic Activity: Evidence from Auditory Signal Processing

Brain‐derived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) study

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