“…Furthermore, despite pharmacological and kinetic properties that resemble the Kv1.4 channel, the transient outward current in the rabbit atrium was inhibited by antisense oligonucleotides directed against Kv4.2 and Kv4.3, with the Kv4.3 antisense oligos having a larger inhibitory effect than Kv1.4 antisense oligos (Wang et al, 1999). Expression of Kv1.4 mRNA in the rabbit ventricle during development does not parallel the marked postnatal increase in I to , whereas expression of all three I to,f subunit genes does match this increase (Abd Allah et al, 2012; Sanchez-Chapula et al, 1994). Similarly, the downregulation of I to observed in rabbit ventricular myocytes in heart failure is paralleled by a decrease in expression of the Kv4.2 and KChIP2 proteins, while Kv1.4 protein levels remain unchanged (Rose et al, 2005).…”