Postnatal development of the human entorhinal cortex

Graterón, L.; Insausti, A.M.; García‐Bragado, F.; Arroyo-Jiménez, M.M.; Marcos, Pilar; Martı́nez-Marcos, Alino; Blaizot, Xavier; Artacho‐Pérula, Emilio; Insausti, Ricardo

doi:10.1093/acprof:oso/9780198509172.003.0002

Cited by 3 publications

(4 citation statements)

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“…After that, they were mounted, air-dried and intensified with osmium thiocarbohydrazide (Lewis et al, 1986). Analysis was performed on an Olympus B-50 microscope coupled to an X-Y charting system (MDPLOT, Accu-Stage, Minneapolis, MN) after cytoarchitectonic evaluation of layers and subfields (Insausti et al, 1995;Grateron et al, 2002).…”

Section: Methodsmentioning

confidence: 99%

“…At the time of birth, the basic gross anatomic features and topological relationships of the human entorhinal cortex are present, although considerable postnatal development takes place mainly during the first postnatal year (Grateron et al, 2002). This protracted maturation prompted us to explore the postnatal maturation of an important set of interneurons (Wouterlood, 2002) that stain positively for the calcium-binding proteins, parvalbumin, calbindin D-28K (further referred to as calbindinin in the future) and calretinin.…”

Section: Introductionmentioning

confidence: 99%

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Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Graterón

Cebada‐Sánchez

Marcos

et al. 2003

Journal of Chemical Neuroanatomy

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Graterón

Cebada‐Sánchez

Marcos

et al. 2003

Journal of Chemical Neuroanatomy

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“…The hypothesized effect was observed on a continuum that also included a positive association between age and ERC volume in individuals with elevated Aβ but low iron content, which was unexpected. Protracted development and maintenance of ERC is consistent with nonpathological aging 14,44 . Iron is necessary for neuronal function but its accumulation within agesensitive regions is an antecedent to metabolic dysfunction, oxidative stress, chronic inflammation and cell death 7,8 .…”

Section: A C C E P T E Dmentioning

confidence: 58%

“…Protracted development and maintenance of ERC is consistent with nonpathologic aging. 14 , 43 Iron is necessary for neuronal function, but its accumulation within age-sensitive regions is an antecedent to metabolic dysfunction, oxidative stress, chronic inflammation, and cell death. 7 , 8 The consequences of iron accumulation are observed across the adult lifespan as neuronal dysfunction indicated by fMRI, 44 , 45 regional brain shrinkage, 20 , 46 and cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume

et al. 2020

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Objective:To test the hypothesis that the combination of both elevated global Aβ burden and greater striatal iron content would be associated with smaller entorhinal cortex (ERC) volume, but not hippocampal subfield volumes, we measured volume and iron content using high resolution MRI and Aβ using PET imaging in a cross-sectional sample of 70 cognitively normal older adults.Methods:Participants were scanned using Florbetapir 18F PET to obtain amyloid-beta standardized uptake value ratios. Susceptibility-weighted MRI was collected and processed to yield R2* images and striatal regions-of-interest (ROIs) were manually placed to obtain a measure of striatal iron burden. Ultra-high-resolution T2/PD weighted MR images were segmented to measure MTL volumes. Analyses were conducted using mixed-effects models with MTL ROI as a within-subject factor and age, iron content, and Aβ as between-subjects factors and MTL volumes (ERC and three hippocampal subfield regions) as the dependent variable.Results:The model indicated a significant four-way interaction among age, iron, Aβ, and MTL region. Post-hoc analyses indicated the three-way interaction among age, Aβ, and iron content was selective to the ERC (β = -3.34, SE = 1.33, 95%CI[-5.95, -0.72]), where a significant negative association between age and ERC volume was only present in individuals with both elevated iron content and Aβ.Conclusions:These findings highlight the importance of studying Aβ in the context of other, potentially synergistic age-related brain factors, such as iron accumulation, as well as highlighting the potential role for iron as an important contributor to the earliest, preclinical stages of pathological aging.

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Postnatal Development of the Primate Hippocampal Formation

Lavenex

Amaral

2006

Dev Neurosci

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The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal formation are thought to contribute to neurodevelopmental disorders, such as autism, schizophrenia, epilepsy and Down syndrome. Despite all that we know about the functional organization of the adult hippocampal formation, notably absent is a systematic study of its postnatal maturation in primates. In this article, we review current knowledge of the structural development of the primate hippocampal formation and present new data on its postnatal neuroanatomical development. We summarize what is known about the neurobiological processes, such as the addition of new neurons, the establishment and elaboration of connectivity, and the neurochemical changes, that underlie the structural development and functional maturation of the primate hippocampal formation. We conclude that there is yet insufficient information to identify distinct developmental windows during which different hippocampal regions undergo specific maturational processes. For this reason, it is currently impossible to determine the ages at which specific hippocampal circuits become structurally mature and potentially capable of supporting defined, age-specific functional processes. Together with work in rodents, systematic studies of the structural development and functional maturation of the monkey hippocampal formation will be necessary to gain insight not only into the types of information processing that it subserves, but also into the specific maturational processes that might be affected in human neurodevelopmental disorders.

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Postnatal development of the human entorhinal cortex

Cited by 3 publications

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Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume

Postnatal Development of the Primate Hippocampal Formation

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