Postnatal development of the cholecystokinin-gastrin family of peptides in the brain and gut of rat

Noyer, Michel; Bui, Ngoc Diem; Deschodt-Lanckman, M; Robberecht, Patrick; Woussen, Marie-Claire; Christophe, Jean

doi:10.1016/0024-3205(80)90384-7

Cited by 36 publications

(9 citation statements)

References 29 publications

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“…The post-natal development of CCK-like biological activity in the brain reported in this study is similar to previously published reports on the appearance of CCK-like immunoreactivity (Schneider, Monahan & Hirsch, 1979;Noyer et al 1980). Throughout the first two weeks of life there is very little CCK present in the brain.…”

Section: Discussionsupporting

confidence: 92%

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The post‐natal development of cholecystokinin‐like activity in the brain and small intestine of the rat.

Brand¹

1982

The Journal of Physiology

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SUMMARY1. The post-natal development of cholecystokinin (CCK)-like activity was studied in the brain and small intestine of the rat. CCK-like biological activity was measured in extracts of these tissues by an in vitro rabbit gall-bladder bioassay.2. Immediately after birth, the brain contained very little CCK-like activity whereas the proximal small intestine contained significant concentrations ofCCK-like activity. The concentration of CCK-like activity in the brain increased rapidly during the third post-natal week and reached adult values by the end of the fourth week. The development of CCK-like activity in the proximal small intestine differed from that seen in the brain. The concentration of CCK-like activity increased during the first post-natal week. After this time, however, the concentration decreased and the adult values, therefore, were lower than those found immediately after birth. This decrease in concentration resulted from failure of the total content of CCK-like activity to increase despite rapid growth of the intestine.3. The composition of CCK-like activity in neonatal extracts was determined by gel filtration chromatography with Sephadex G50. Extracts of neonatal brain and intestine contained more than one molecular form of CCK-like activity in contrast to the single peak of activity found in adult extracts. In the developing intestine smaller molecular forms were found in addition to the single larger form found in the adult and in the neonatal brain larger molecular forms were found in addition to the CCK octapeptide found in the adult.

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Section: Discussionsupporting

confidence: 92%

“…(Lichtenberger & Johnson, 1974;Larsson et al 1976). One study has investigated the development of CCK/gastrin-like immunoreactivity in both brain and intestine and reported distinct differences between the two tissues (Noyer et al 1980). Unfortunately the antisera used did not distinguish betweek CCK and gastrin.…”

Section: Introductionmentioning

confidence: 99%

The post‐natal development of cholecystokinin‐like activity in the brain and small intestine of the rat.

Brand¹

1982

The Journal of Physiology

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“…During the last decade, several studies have examined the ontogenetic expression of CCK peptides [28][29][30][31][32][33] and CCK mRNA [33,34] in rodent brains. The earlier pep tide studies have, however, used assays that measured only the bioactive, carboxyamidated CCK peptides [28,33].…”

Section: Discussionmentioning

confidence: 99%

“…The earlier pep tide studies have, however, used assays that measured only the bioactive, carboxyamidated CCK peptides [28,33]. Moreover, with a single exception [30], they have studied only whole brain, cerebral cortex and other telencephalic regions, but not the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of Procholecystokinin Processing in Rat Hypothalamus

Mogensen¹,

Hilsted²,

Bardram

et al. 1991

Dev Neurosci

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The concentration of procholecystokinin (pro-CCK) in the fetal hypothalamus was 126 ± 41 pmol/g (mean ± SEM; n = 20), 22 ± 9 pmol/g at day 7 postpartum and 3 ± 2 pmol/g in the adult. In contrast, the concentration of bioactive carboxyamidated CCK rose from 6 ± 2 pmol/g in the fetal hypothalamus to 52 ± 10 pmol/g in the adult. The concentration of glycine-extended processing intermediates first decreased from 21 ± 5 pmol/g in the fetus to 5 ± 1 pmol/g at day 21 postpartum. Subsequently, the concentration rose to 21 ± 4 pmol/g in the adult. The results show that the CCK gene is well expressed in the fetal hypothalamus. However, only a small fraction of pro-CCK reaches maturation before weaning. We conclude that expression of the CCK gene in the hypothalamus as bioactive peptide to a large degree is regulated at the posttranslational level.

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“…The various kinds of fluctuations of peptides in the central and peripheral nervous system during the ontogeny (see ref. 25 for a review) is recently confirmed by radioimmunoassay system (1,5,14).…”

mentioning

confidence: 87%

Ontogeny of neuropeptides in the rat brain: An immunohistochemical analysis.

Tohyama

1985

Acta Histochem. Cytochem

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Postnatal development of the cholecystokinin-gastrin family of peptides in the brain and gut of rat

Cited by 36 publications

References 29 publications

The post‐natal development of cholecystokinin‐like activity in the brain and small intestine of the rat.

The post‐natal development of cholecystokinin‐like activity in the brain and small intestine of the rat.

Ontogeny of Procholecystokinin Processing in Rat Hypothalamus

Ontogeny of neuropeptides in the rat brain: An immunohistochemical analysis.

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