Postnatal development of the basolateral complex of rabbit amygdala: a stereological and histochemical study

Majewska, Hanna; Wójcik, Sławomir; Dziewíatkowski, J; Łuczyńska, Anna; Kurlapska, R.; Moryś, Janusz

doi:10.1046/j.1469-7580.2003.00240.x

Cited by 11 publications

(8 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This period of rapid enlargement is followed by a much slower maturation that extends beyond 3 months of age, when the basolateral amygdala has reached about 95% of the volume observed in 6-month-old rats (Berdel et al, 1997b; Rubinow and Juraska, 2009). In the rabbit, the combined volume of the lateral, basal and accessory basal nuclei increases linearly from birth (12% of adult value) to 4 months of age, when it reaches the value observed in 6-month-old animals (Jagalska-Majewska et al, 2003). Interestingly, and similar to what we found in monkeys, the medial nucleus reaches an adult volume between P5 and P11 in rats (Mizukami et al, 1983), an age at which the combined volume of the lateral and basal nuclei is still less than 80% of the adult value (Berdel et al, 1997b).…”

Section: Discussionmentioning

confidence: 81%

Postnatal development of the amygdala: A stereological study in macaque monkeys

Chareyron

Lavenex

Amaral

et al. 2012

J of Comparative Neurology

111

View full text Add to dashboard Cite

Abnormal development of the amygdala has been linked to several neurodevelopmental disorders, including schizophrenia and autism. However, the postnatal development of the amygdala is not easily explored at the cellular level in humans. Here we performed a stereological analysis of the macaque monkey amygdala in order to characterize the cellular changes underlying its normal structural development in primates. The lateral, basal, and accessory basal nuclei exhibited the same developmental pattern, with a large increase in volume between birth and 3 months of age, followed by slower growth continuing beyond 1 year of age. In contrast, the medial nucleus was near adult size at birth. At birth, the volume of the central nucleus was half of the adult value; this nucleus exhibited significant growth even after 1 year of age. Neither neuronal soma size, nor neuron or astrocyte numbers changed during postnatal development. In contrast, oligodendrocyte numbers increased substantially, in parallel with an increase in amygdala volume, after 3 months of age. At birth, the paralaminar nucleus contained a large pool of immature neurons that gradually developed into mature neurons, leading to a late increase in the volume of this nucleus. Our findings revealed that distinct amygdala nuclei exhibit different developmental profiles and that the amygdala is not fully mature for some time postnatally. We identified different periods during which pathogenic factors might lead to the abnormal development of distinct amygdala circuits, which may contribute to different human neurodevelopmental disorders associated with alterations of amygdala structure and functions.

show abstract

Section: Discussionmentioning

confidence: 81%

Postnatal development of the amygdala: A stereological study in macaque monkeys

Chareyron

Lavenex

Amaral

et al. 2012

J of Comparative Neurology

111

View full text Add to dashboard Cite

show abstract

“…) and other existing literature in pups (Jagalska‐Majewska et al. , ,b) or adult rabbits (Varga et al. ; Równiak et al.…”

Section: Methodsmentioning

confidence: 87%

“…In the 4‐day‐old pup (see also Jagalska‐Majewska et al. , ,b at other ages in the young), the amygdala structure resembles that of the adult rabbit (Równiak et al. ) but is more compact, with some subregions not identifiable.…”

Section: Methodsmentioning

confidence: 94%

Brain anatomy of the 4‐day‐old European rabbit

2018

View full text Add to dashboard Cite

The European rabbit (Oryctolagus cuniculus) is a widely used model in fundamental, medical and veterinary neurosciences. Besides investigations in adults, rabbit pups are relevant to study perinatal neurodevelopment and early behaviour. To date, the rabbit is also the only species in which a pheromone - the mammary pheromone (MP) - emitted by lactating females and active on neonatal adaptation has been described. The MP is crucial since it contributes directly to nipple localisation and oral seizing in neonates, i.e. to their sucking success. It may also be one of the non-photic cues arising from the mother, which stimulates synchronisation of the circadian system during pre-visual developmental stages. Finally, the MP promotes neonatal odour associative and appetitive conditioning in a remarkably rapid and efficient way. For these different reasons, the rabbit offers a currently unique opportunity to determine pheromonal-induced brain processing supporting adaptation early in life. Therefore, it is of interest to create a reference work of the newborn rabbit pup brain, which may constitute a tool for future multi-disciplinary and multi-approach research in this model, and allow comparisons related to the neuroethological basis of social and feeding behaviour among newborns of various species. Here, in line with existing experimental studies, and based on original observations, we propose a functional anatomical description of brain sections in 4-day-old rabbits with a particular focus on seven brain regions which appear important for neonatal perception of sensory signals emitted by the mother, circadian adaptation to the short and single daily nursing of the mother in the nest, and expression of specific motor actions involved in nipple localisation and milk intake. These brain regions involve olfactory circuits, limbic-related areas important in reward, motivation, learning and memory formation, homeostatic areas engaged in food anticipation, and regions implicated in circadian rhythm and arousal, as well as in motricity.

show abstract

“…g-r Micrographs taken from sections stained for CGRP (g, j), Timm (k, l), AChE (m-o) and Pav (p, r), in part with adjacent sections stained for cresyl violet (h, i, q). Note the Pav positive cells in AyB (p) and AyL (r) and the differential fiber staining of these regions; the extensive AChE staining appears to involve the medial and lateral AyB, as well as portions of AyP (for comparison see Jagalska-Majewska et al 2003;Muller et al 2006;Rocha-Rego et al 2008). Th thalamus, v and w, unidentified cell regions.…”

Section: Resultsmentioning

confidence: 96%

Amygdalar connections in the lesser hedgehog tenrec

Künzle

2011

Brain Struct Funct

View full text Add to dashboard Cite

The present study analyses the overall extrinsic connectivity of the non-olfactory amygdala (Ay) in the lesser hedgehog tenrec. The data were obtained from tracer injections into the lateral and intermediate portions of the Ay as well as several non-amygdalar brain regions. Both the solitary and the parabrachial nucleus receive descending projections from the central nucleus of the Ay, but only the parabrachial nucleus appears to project to the Ay. There is one prominent region in the ventromedial hypothalamus connected reciprocally with the medial and central Ay. Amygdalar afferents clearly arise from the dorsomedial thalamus, the subparafascicular nuclei and the medial geniculate complex (GM). Similar to other subprimate species, the latter projections originate in the dorsal and most caudal geniculate portions and terminate in the dorsolateral Ay. Unusual is the presence of amygdalo-projecting cells in the marginal geniculate zone and their virtual absence in the medial GM. As in other species, amygdalo-striatal projections mainly originate in the basolateral Ay and terminate predominantly in the ventral striatum. Given the poor differentiation of the tenrec's neocortex, there is a remarkable similarity with regard to the amygdalo-cortical connectivity between tenrec and rat, particularly as to prefrontal, limbic and somatosensorimotor areas as well as the rhinal cortex throughout its length. The tenrec's isocortex dorsomedial to the caudal rhinal cortex, on the other hand, may not be connected with the Ay. An absence of such connections is expected for primary auditory and visual fields, but it is unusual for their secondary fields.

show abstract

Postnatal development of the basolateral complex of rabbit amygdala: a stereological and histochemical study

Cited by 11 publications

References 70 publications

Postnatal development of the amygdala: A stereological study in macaque monkeys

Postnatal development of the amygdala: A stereological study in macaque monkeys

Brain anatomy of the 4‐day‐old European rabbit

Amygdalar connections in the lesser hedgehog tenrec

Contact Info

Product

Resources

About