1987
DOI: 10.1016/0020-711x(87)90334-x
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Postnatal development of the actual and total activity of the branched-chain 2-oxo acid dehydrogenase complex in rat tissues

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Cited by 4 publications
(6 citation statements)
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“…It has been reported [46] that the liver BCKDC activity increases in rat pups throughout the suckling period, reaching adult levels at the age of weaning (21 days). In addition, total BCKDC activity in the liver rises during postnatal development (until 30-40 days of age) and then tends to drop at around 60 to 70 days of age [47,48]. To our knowledge, no further information is available regarding age-dependent changes in rat hepatic BCKDC activity after 10 weeks of age; thus, this issue needs further clarification in future studies.…”
Section: Discussionmentioning
confidence: 77%
“…It has been reported [46] that the liver BCKDC activity increases in rat pups throughout the suckling period, reaching adult levels at the age of weaning (21 days). In addition, total BCKDC activity in the liver rises during postnatal development (until 30-40 days of age) and then tends to drop at around 60 to 70 days of age [47,48]. To our knowledge, no further information is available regarding age-dependent changes in rat hepatic BCKDC activity after 10 weeks of age; thus, this issue needs further clarification in future studies.…”
Section: Discussionmentioning
confidence: 77%
“…An age-dependent increase in BCODC activity during neonatal development of the rat has been documented previously by others [9][10][11]. The work of May et al [9] first described the developmental pattern for the liver, but whether the increase throughout the suckling period was due to a change in enzyme mass or covalent modification was not investigated.…”
Section: Discussionmentioning
confidence: 83%
“…The work of May et al [9] first described the developmental pattern for the liver, but whether the increase throughout the suckling period was due to a change in enzyme mass or covalent modification was not investigated. Veerkamp et al [10] and Grogan et al [11] measured enzyme activity by a flux method [32] and concluded that the hepatic enzyme was largely in its active, dephosphorylated form throughout postnatal development. The present work further documents the increase in hepatic enzyme activity throughout the suckling period of development and confirms that the increase in enzyme activity in the liver is due to an increase in expressed amount of BCODC subunits rather than a change in activity (phosphorylation) state of the enzyme.…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies have reported hepatic BCKAD activity states of nearly 100% in neonatal rat pups Ͻ12 h old (39,40). However, our study focuses on fetal rat pups, which differ from neonatal rat pups in several ways.…”
Section: Liver and Muscle Bckad In Iugr Fetal Ratsmentioning
confidence: 99%