Postnatal development of synaptic plasticity in the CA3 hippocampal region of control and lead-exposed Wistar rats

Gutowski, Martin; Altmann, L; Sveinsson, Karolina; Wiegand, Herbert

doi:10.1016/s0165-3806(96)00178-2

Cited by 9 publications

(2 citation statements)

References 41 publications

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“…Hippocampal CA3 has been less studied, although Gutowski et al (46) report that they did not observe any effect of developmental exposure to lead on LTP at this synapse. Their study and ours have several technical differences, and the different results may reflect either these differences or the ages of the animals at the time of the experiments.…”

Section: Lead and Pcbs Have Similar Effects On Ltpmentioning

confidence: 98%

Electrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.

Carpenter

Hussain

Berger

et al. 2002

Environ Health Perspect

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Lead and polychlorinated biphenyls (PCBs) both cause a reduction of intelligence quotient and behavioral abnormalities in exposed children that have features in common with attention deficit hyperactivity disorder. We have used rats as a model to study the effects of both perinatal and acute exposure to lead or PCBs in an effort to compare and understand the mechanisms of these nervous system decrements. Long-term potentiation (LTP) is an electrophysiologic measurement that correlates well with cognitive ability. We have determined the effects of chronic perinatal exposure to lead or PCB 153 as well as acute application of these substances to isolated brain slices, with recordings in two areas of the hippocampus, CA1 and CA3. Both substances, whether chronically or acutely applied, significantly reduced LTP in CA1 in animals at age 30 and 60 days. In CA3, they reduced LTP in 30-day animals but potentiated it in 60-day animals. Although neither lead nor PCB 153 alters baseline synaptic transmission at low stimulus strengths, at higher levels they induce changes in the same direction as those of LTP. These results show surprisingly similar actions of these quite different chemicals, and the similarity of effects on chronic and acute application indicates that effects are both pharmacologic and developmental. Behavioral studies of rats exposed to PCBs from contaminated fish show hyperactivity, impulsiveness, and increased frustration relative to unexposed controls. These results demonstrate that lead and PCBs have similar effects on synaptic plasticity and behavior and suggest that the compounds may act through a common mechanism. Key words: brain slice, extinction, frustration, hippocampus, hyperactivity, input-output curves, long-term potentiation, perinatal exposure.

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Section: Lead and Pcbs Have Similar Effects On Ltpmentioning

confidence: 98%

Electrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.

Carpenter

Hussain

Berger

et al. 2002

Environ Health Perspect

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“…Results of our present study showed that Cd exposure alters the aminergic system in synaptosomal catecholamine levels in the order of hippocampus, cerebral cortex and cerebellum. Several reports indicate that the hippocampus (23,24) and nucleus accumbens (25) are important targets of this neurotoxic heavy metals such as lead and Cd. Andersson (26) have shown alterations in DA, 3,4-dihydroxyphenyl acetic acid (DOPAC), 5-HT, and 5-HIAA content and metabolism in hippocampus, frontal cortex and striatum of rats exposed to Cd.…”

Section: Epinephrine Activitymentioning

confidence: 99%

Outcome of Cadmium on Aminergic System and Protective Function of Vitamin-C

Jyostna.V¹,

Anuhya.G²,

Managamuri³

et al. 2018

IJSRBS

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Cadmium (Cd) is an extremely toxic metal and has a long biological half-life in humans, it enters the brain parenchyma and neurons causing neurological alterations in humans and animal models, leading to lower attention, hyper nociception, olfactory dysfunction and memory deficits. Rats were exposed to low (2mg/kg bw) and high dose (5mg/kg bw) of Cd through subcutaneous injections. The activity levels of epinephrine, norepinephrine and dopamine contents were studied in discrete brain areas of the young rats such as hippocampus, cerebral cortex and cerebellum. Hippocampal levels of catecholamines were significantly reduced in rats exposed to Cd. Our data suggest that Cd exposure disturbs aminergic system in the hippocampus, cerebral cortex and cerebellum and may contribute to the alterations in neurotransmitters.

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Nervous System

Andreas¹,

Ray

1999

Toxicology

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Postnatal development of synaptic plasticity in the CA3 hippocampal region of control and lead-exposed Wistar rats

Cited by 9 publications

References 41 publications

Electrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.

Electrophysiologic and behavioral effects of perinatal and acute exposure of rats to lead and polychlorinated biphenyls.

Outcome of Cadmium on Aminergic System and Protective Function of Vitamin-C

Nervous System

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