Postnatal development of NR1, NR2A and NR2B immunoreactivity in the visual cortex of the rat

Cao, Zhiping; Lickey, Marvin E.; Liu, Lijuan; Kirk, E.; Gordon, Barbara

doi:10.1016/s0006-8993(99)02450-6

Cited by 25 publications

(20 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As day length increases and NR2B levels decrease, the threshold for LTP is likely to be raised, thereby increasing synaptic competition and promoting an experience-driven synaptic refinement of this new and exuberant circuitry. This model is consistent with recent studies suggesting that developmental decreases in the NR2B:NR2A ratio are more closely associated with the beginning, rather than the end, of periods for experience-dependent plasticity (Roberts and Ramoa, 1999;Cao et al, 2000a, b;Singh et al, 2000). While this scenario seems inconsistent with the absence of photoperiod-induced changes in NMDAR subunit expression within the HVc, a region exhibiting substantial photoperiod-induced neural growth and reorganization (Nottebohm, 1981; but see Leitner et al, 2001), measures of NMDAR mRNA in this nucleus need to be interpreted cautiously.…”

Section: Discussionsupporting

confidence: 92%

Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system

et al. 2003

View full text Add to dashboard Cite

Developmental changes in the composition and function of N-methyl-D-aspartate receptors (NMDARs) are believed to regulate neural plasticity. For example, in songbirds, vocal learning entails NMDAR activation, and the sensitive period for such learning in zebra finches (ZFs) parallels developmental changes in NMDAR density and phenotype within several song-related brain regions. In contrast to ZFs, canaries exhibit vocal plasticity recurrently throughout adulthood, prompted by seasonal changes in day length and testosterone (T) levels. We used in situ hybridization to determine if such changes in photoperiod affect NMDAR subunit expression in adult canaries. Birds were sacrificed while on short days (SD) when T levels were low, or on long days (LD) when T levels were high. Transcript levels for the constitutive NMDAR subunit (NR1) and two modulatory subunits (NR2A, NR2B) were measured in four song control nuclei: lMAN, Area X, HVc, and RA. NR1 and NR2A mRNA levels were comparable in SD and LD groups in all four song regions studied. However, NR2B mRNA levels within lMAN and RA were significantly higher in SD than in LD birds. Photoperiod did not affect NR2B transcript levels in Area X, HVc, or a nonsong region just lateral to lMAN. Our data support the hypothesis that changes in NMDAR subunit expression may contribute to the neural and behavioral reorganization that accompanies seasonal song remodeling in adulthood.

show abstract

Section: Discussionsupporting

confidence: 92%

Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system

et al. 2003

View full text Add to dashboard Cite

show abstract

“…Synaptic plasticity in the AC is reduced by administration of 2‐amino‐5‐ phosphonovaleric acid (APV) (Kudoh and Shibuki, 1994, 1997a, b) and ifenprodil (Mao et al, 2006), the antagonists of the N ‐methyl‐D‐aspartic acid (NMDA) receptor. These findings provide evidence of NMDA‐receptor‐mediated developmental plasticity in the AC, which is known to be the case in the visual cortex (VC) (Nowicka and Kaczmarek, 1996; Catalano et al, 1997; Quinlan et al, 1999; Roberts and Ramoa, 1999; Cao et al, 2000a; Mower and Chen, 2003) and in the barrel cortex (Iwasato et al, 2000; Lee et al, 2005).…”

mentioning

confidence: 69%

Early auditory deprivation alters expression of NMDA receptor subunit NR1 mRNA in the rat auditory cortex

Lü

Cui

Cai

et al. 2007

J of Neuroscience Research

View full text Add to dashboard Cite

The expression of NMDA receptor NR1 subunit mRNA was studied in rat auditory cortex (AC) on different postnatal days using digoxigenin-labeled oligonucleotide probes. The results showed that NR1expression increased from birth to postnatal day 35 (P35) and remained constant until P56. The most significant increases occurred between P7 and P14. Changes in NR1 mRNA expression in rats subjected to monaural hearing deprivation on P7, P21, P35, and P49 were examined on P56. Between P7 and P21, when the rat auditory system was still in a critical period of development, NR1 mRNA expression was lower in the contralateral AC, which received auditory signals from the plugged ear, than in the ipsilateral AC. However, no significant difference was observed between the rats deprived of hearing on P35 and those deprived of hearing on P42, the end of the critical period of auditory development. These results showed that monaural hearing deprivation during early postnatal development was associated with decreased NR1 mRNA expression in the contralateral AC and suggested the involvement of NR1 in auditory function during development. They also indicated that, during postnatal development, environmental factors changed the functional plasticity of neurons in the AC through NR1 receptor expression. Taken together, these findings provide a possible underlying mechanism for the development of postnatal auditory function. V V C 2007 Wiley-Liss, Inc.

show abstract

“…Cortical glutamatergic and GABAergic networks that synchronize the firing of pyramidal neurons and sculpt the temporal profile of cortical oscillations (Whittington et al, 2000;Cardin et al, 2009) also undergo substantial adolescent maturation (Cao et al, 2000;Hashimoto et al, 2009). Coincident adolescent development of the cortical eCB system includes reduced CB1R expression (Deshmukh et al, 2007;Heng et al, 2011) and changes in eCB metabolism (Long et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Raver

Haughwout

Keller

2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Regular marijuana use during adolescence, but not adulthood, may permanently impair cognition and increase the risk for psychiatric diseases, such as schizophrenia. Cortical oscillations are integral for cognitive processes and are abnormal in patients with schizophrenia. We test the hypothesis that adolescence is a sensitive period because of the active development of cortical oscillations and neuromodulatory systems that underlie them. The endocannabinoid system upon which marijuana acts is one such system. Here we test the prediction that adolescent cannabinoid exposure alters cortical oscillations in adults. Using in vitro local field potential, in vivo electrocorticogram recordings and cognitive behavioral testing in adult mice, we demonstrate that chronic adolescent, but not adult, cannabinoid exposure suppresses pharmacologically evoked cortical oscillations and impairs working memory performance in adults. The later-maturing prefrontal cortex is more sensitive to adolescent exposure than the earlier-maturing, primary somatosensory cortex. These data establish a link between chronic adolescent cannabinoid exposure and alterations in adult cortical network activity that underlie cognitive processes.

show abstract

Postnatal development of NR1, NR2A and NR2B immunoreactivity in the visual cortex of the rat

Cited by 25 publications

References 36 publications

Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system

Seasonal regulation of NMDA receptor NR2B mRNA in the adult canary song system

Early auditory deprivation alters expression of NMDA receptor subunit NR1 mRNA in the rat auditory cortex

Adolescent Cannabinoid Exposure Permanently Suppresses Cortical Oscillations in Adult Mice

Contact Info

Product

Resources

About