Postnatal development of bulbospinal serotoninergic system. effects of GMI ganglioside following neonatal 5,7-dihydroxytryptamine treatment

Fusco, Mariella; Figliomeni, B.; Gorio, Alfredo; Vantini, G.

doi:10.1016/0197-0186(88)90062-9

Cited by 6 publications

(1 citation statement)

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“…Treating neonatal rats with the selective neurotoxin 5,7-dihydroxytryptamine results in the loss of serotonin nerve terminal projections in the brain and spinal cord and decreases the content of serotonin and the activity of its transport by nerve endings. One subcutaneous injection of GM1 daily during postnatal days 1-4, started 2-3 h after the neurotoxin, apparently does not interfere with the induction of the lesion, but it favors the recovery of deficient serotonergic neurochemical markers and enhances serotonergic terminal density when animals are studied 1 month later (Jonsson et a!., 1984b;Fusco et a!., 1986Fusco et a!., , 1988. Similar observations have been made in adult rats (Jonsson et a!., 1984a;Kojima et al, 1988).…”

Section: Serotonergic and Noradrenergic Neuronssupporting

confidence: 56%

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Hadjiconstantinou

Neff

1998

Journal of Neurochemistry

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There is now substantial evidence that GM1 ganglioside is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in vitro model systems. Although the molecular mechanism(s) and the substrates for the neurotrophic activity of the gangliosides are not fully understood, the published experimental work suggests that GM1 has antineurotoxic, neuroprotective, and neurorestorative effects on various central neurotransmitter systems. This review focuses attention on studies reporting that GM1 restores neuronal integrity and function in the brain of lesioned young as well as aged animals. Critical analysis of these studies can provide guidance for future ganglioside research and may point to novel approaches for treating neuroinjury and a variety of degenerative conditions, including aging.

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Section: Serotonergic and Noradrenergic Neuronssupporting

confidence: 56%

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Hadjiconstantinou

Neff

1998

Journal of Neurochemistry

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Involvement of Gangliosides in Neuroplasticity of the Central Nervous System in Physiological and Pathological Conditions

Agnati

Zoli

Biagini

et al. 1992

Current Aspects of the Neurosciences

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Ganglioside function in the development and repair of the nervous system

1989

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Gangliosides play important roles in the normal physiological operations of the nervous system, in particular that of the brain. Changes in ganglioside composition occur in the mammalian brain not only during development, but also in aging and in several neuropathological situations. Gangliosides may modulate the ability of the brain to modify its response to cues or signals from the microenvironment. For example, cultured neurons are known to respond to exogenous ganglioside with changes characteristic of cell differentiation. Gangliosides can amplify the responses of neurons to extrinsic protein factors (neuronotrophic factors) that are normal constituents of the neuron's environment. The systemic administration of monosialoganglioside also potentiates trophic actions in vivo and improves neural responses following various types of injury to the adult mammalian central nervous system. The possible molecular mechanism(s) underlying the ganglioside effects may reflect an action in modulating ligand-receptor linked transfer of information across the plasma membrane of the cell.

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Postnatal development of bulbospinal serotoninergic system. effects of GMI ganglioside following neonatal 5,7-dihydroxytryptamine treatment

Cited by 6 publications

References 43 publications

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Involvement of Gangliosides in Neuroplasticity of the Central Nervous System in Physiological and Pathological Conditions

Ganglioside function in the development and repair of the nervous system

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