Postnatal Development of Blood Serum Concentrations of Immunoglobulin IgG, IgA and IgM Isotypes in Suckling Foal

Sedlinská, Markéta; Krejcí, J; Vyskočil, M.; Kudláčková, Hana

doi:10.2754/avb200675020175

Cited by 7 publications

(11 citation statements)

References 4 publications

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“…In agreement with the current study, onset of IgA synthesis in foals has been reported to occur at approximately 1-2 months of age [18]. Mean periparturient mare serum IgA concentrations were comparable with values reported in a small group of Thorougbred mares [11] and another of mixed-breed horses [16] but lower than a study of 27 mixed-breed adults [14]. In contrast, colostrum and milk concentrations of IgA were found to be lower than those described in previous studies [11,16].…”

Section: Discussionsupporting

confidence: 92%

“…The concentrations of IgA measured in Australian Thoroughbreds are comparable to those found in in a study of 52 European Thoroughbred foals . The rapid reduction of IgA concentration in the foal serum from 12 h to 19 days after parturition is likely due to gut closure and utilisation of passively transferred IgA and is consistent with the response observed for IgG .…”

Section: Discussionsupporting

confidence: 84%

“…Mean periparturient mare serum IgA concentrations were comparable with values reported in a small group of Thorougbred mares [11] and another of mixed-breed horses [16] but lower than a study of 27 mixed-breed adults [14]. In contrast, colostrum and milk concentrations of IgA were found to be lower than those described in previous studies [11,16]. The significance of persistent IgA levels in mares' milk after closure of the window for absorption of maternal IgA appears to have had limited exploration in the horse [8].…”

Section: Discussionsupporting

confidence: 80%

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Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals

Jenvey

Caraguel

Howarth

et al. 2012

Equine Veterinary Journal

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SummaryReasons for performing the study: Prior to the start of endogenous production of immunoglobulins (Igs), absorption of maternal Igs is important to protect against pathogens in the early neonatal period. It is possible that mare-or foal-associated factors may influence neonatal IgA concentrations. Objectives: The temporal relationships among serum and milk IgA concentrations in Thoroughbred mare-foal pairs were explored to determine if periparturient mare-and foal-associated factors contribute to the prediction of foal serum IgA concentrations. Methods: Blood and milk samples as well as complete veterinary records, were collected for 84 Thoroughbred mare-foal pairs from one month before to 2 months after parturition. Samples were tested using enzyme-linked immunosorbent assay (ELISA) for concentrations of IgA. Pairwise correlation coefficients were estimated (P<0.01) and simple linear regression used to investigate unconditional associations between mare IgA levels, mare and foal risk factors and foal serum IgA concentration at 12 h. Backwards, stepwise elimination of nonsignificant factors was used to create a final model. Results: There were significant temporal relationships among mare serum IgA and among colostrum and milk IgA concentrations within mares (P<0.01). Mare serum IgA concentrations up to one month before parturition were associated with foal serum IgA concentrations at all time points and with colostrum and milk IgA concentrations. Mare serum IgA at -28 days and parity were associated with foal serum IgA concentration at 12 h (P<0.001). Conclusions: Mare serum IgA concentrations up to 28 days before parturition, together with mare parity, are indicative of neonatal foal serum IgA concentrations. Potential relevance: Mare serum and colostrum IgA concentrations may be useful peripartum predictors of neonatal mucosal immune status, enabling earlier intervention to prevent the consequences of mucosal infections.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 80%

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Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals

Jenvey

Caraguel

Howarth

et al. 2012

Equine Veterinary Journal

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“…Most studies are focused predominantly on IgG instead of total Ig because of their concentration in serum; this is due to the function of IgG, most of which is absorbed and protect the newborn foal from systemic infections (Sedlinská et al, 2006). These results may be explained by major ontogenetic impacts on the quality of mammary gland secretions (Chavatte-Palmer et al, 2002), which was also observed in our experiment.…”

Section: Discussionsupporting

confidence: 60%

Influence of sulpiride treatment on the level of prolactin and immunoglobulins in the peripheral blood of mares during the postpartum period

Migdał

Zagrajczuk

et al. 2017

Acta Veterinaria Hungarica

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The aim of this study was to determine the effect of increased levels of prolactin (PRL) on the concentration of immunoglobulins in the blood, colostrum and milk of mares. The study was conducted on 12 mares of the Polish Pony breed (6 in the control and 6 in the experimental group). To induce hyperprolactinaemia in mares of the experimental group, 750 mg sulpiride was administered orally once a day. The initial PRL concentration was 52.22 ± 11.21 ng/ml in the control group and 49.39 ± 10.12 ng/ml in the experimental group. In the subsequent days, the concentration of PRL dynamically changed. Statistical analysis showed highly significant differences (P < 0.01) between the groups. The concentration of immunoglobulins in the blood plasma was at the same level during the experimental period (32.97-29.08 mg/ml in the experimental group and 28.60-18.11 mg/ml in the control group). Statistical analysis showed highly significant differences between the groups in blood plasma immunoglobulin level (P < 0.01). The highest immunoglobulin concentration was obtained within 12 h after parturition in the control and the experimental group (23.49 ± 2.12 mg/ml and 26.94 ±1.72 mg/ml, respectively). The lowest values were obtained on day 12 after parturition in the experimental group (10.15 mg/ml ± 1.47 mg/ml) and on day 7 after parturition in the control group (14.30 mg/ml ± 2.48 mg/ml). In conclusion, this study did not provide evidence that the lactogenic hormone prolactin is involved in the transfer of immunoglobulins into the colostrum in horses.

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“…Foals, calves and piglets are born without placental transfer of Ig from the mother to the fetus and are agammaglobulinaemic at birth. They are therefore solely dependent on intestinal uptake of Ig from colostrum for passive immunization (Curadi et al., 2001; Sangild, 2003; Sedlinská et al., 2006). Likewise, placental transfer of fat‐soluble vitamins, such as vitamin E, is limited (Lauridsen and Jensen, 2007).…”

Section: Introductionmentioning

confidence: 99%

Administration of RRR-α-tocopherol to pregnant mares stimulates maternal IgG and IgM production in colostrum and enhances vitamin E and IgM status in foals

Bondo

Jensen

2010

Journal of Animal Physiology and Animal Nutrition

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This study assessed the effect of a vitamin E supplement given to pregnant mares on immunoglobulins (Ig) levels in foals. In addition, the fatty acid (FA) content and composition of the mares' milk was assessed. Milk α-tocopherol concentrations were compared between pregnant Danish Warmblood mares (n = 17) given a daily oral supplement of 2500 international units (IU) RRR-α-tocopherol in the last 4 weeks of pregnancy and a group of unsupplemented mares (n = 17) receiving 170-320 IU vitamin E daily originating from the feed. Milk α-tocopherol was higher in supplemented mares (36.7, 12.4 and 9.8 μmol/l respectively) in relation to control mares (13.1, 6.4 and 5.8 μmol/l on days 1, 2 and 3 respectively; p < 0.001). Milk IgG was higher on days 2 and 3 post-partum (PP) in supplemented mares (1.03 and 0.73 mg/ml respectively) in relation to control mares (0.79 and 0.56 mg/ml respectively; p < 0.05). Milk IgM was higher on days 2 and 3 post-partum (PP) in supplemented mares (0.19 and 0.17 mg/ml) in relation to control mares (0.13 and 0.11 mg/ml respectively; p < 0.05). Plasma α-tocopherol in foals was higher from supplemented mares on days 1, 2 and 3 (5.7, 14.8 and 19.2 μmol/l respectively) in relation to foals from control mares (3.6, 6.1 and 7.6 respectively; p < 0.001). Foal plasma IgM was higher from supplemented mares on day 3 (0.50 mg/ml) in relation to foals from control mares (0.32 mg/ml; p < 0.001). The total FA content in milk was highest on day 1 (21.6 g FA/kg milk) in relation to days 2 and 3 (13.6 and 13.5 g FA/kg milk respectively; p < 0.001). In conclusion, a daily oral supplement of 2500 IU RRR-α-tocopherol increased α-tocopherol content in mare milk and foal plasma, IgG and IgM in mare milk and IgM in foal plasma.

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Postnatal Development of Blood Serum Concentrations of Immunoglobulin IgG, IgA and IgM Isotypes in Suckling Foal

Cited by 7 publications

References 4 publications

Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals

Identification of periparturient mare and foal associated predictors of post parturient immunoglobulin A concentrations in Thoroughbred foals

Influence of sulpiride treatment on the level of prolactin and immunoglobulins in the peripheral blood of mares during the postpartum period

Administration of RRR-α-tocopherol to pregnant mares stimulates maternal IgG and IgM production in colostrum and enhances vitamin E and IgM status in foals

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