Postnatal development of a large auditory nerve terminal: The endbulb of Held in cats

Ryugo, David K.; Montey, Karen L.; Wright, Alison; Bennett, Mariko L.; Pongstaporn, Tan

doi:10.1016/j.heares.2006.01.007

Cited by 39 publications

(60 citation statements)

References 60 publications

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“…It was also consistent with a lack of change in RRP size which varies with tetanic depression (Brenowitz and Trussell, 2001a;Brenowitz et al, 1998;Oleskevich et al, 2002). The number of release sites remained unchanged between P7 and P16, which is in keeping with the morphological maturation of the endbulb in the cat (Ryugo et al, 2006) and mouse (Limb and Ryugo, 2000) where the endbulb becomes more extensively branched and complex with age. Most of the anatomical changes in the mouse take place after postnatal week four and do not reach adult-like complexity until the ninth postnatal week.…”

Section: Development Of Synaptic Strength In Normal Micesupporting

confidence: 78%

The role of spontaneous activity in development of the endbulb of Held synapse

McKay

Oleskevich

2007

Hearing Research

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Section: Development Of Synaptic Strength In Normal Micesupporting

confidence: 78%

The role of spontaneous activity in development of the endbulb of Held synapse

McKay

Oleskevich

2007

Hearing Research

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“…3). Ultrastructural studies in the cat have shown that the earliest contacts between endbulbs and SBCs are irregular, with a ruffled “caterpillar-like” appearance (Ryugo et al, 2006). At these stages, the endbulbs appear to attach to the SBC cell surface via vesicle-free symmetrical membrane thickenings called puncta adherentia .…”

Section: Development Of the Endbulb Of Heldmentioning

confidence: 99%

Morphological and physiological development of auditory synapses

Goodrich

2014

Hearing Research

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Acoustic communication requires gathering, transforming, and interpreting diverse sound cues. To achieve this, all the spatial and temporal features of complex sound stimuli must be captured in the firing patterns of the primary sensory neurons and then accurately transmitted along auditory pathways for additional processing. The mammalian auditory system relies on several synapses with unique properties in order to meet this task: the auditory ribbon synapses, the endbulb of Held, and the calyx of Held. Each of these synapses develops morphological and electrophysiological characteristics that enable the remarkably precise signal transmission necessary for conveying the miniscule differences in timing that underly sound localization. In this article, we review the current knowledge of how these synapses develop and mature to acquire the specialized features necessary for the sense of hearing.

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“…In normal development, Larsen (1984) noted that large spherical cells in the cat AVCN increase rapidly in cross-sectional area during the first month of life, achieving 70% of their normal adult size at about 4-5 weeks of age. Changes in cell ultrastructure, including maturation of postsynaptic densities, intermembranous cisternae and cellular membranes, also occur during the first 30 days postnatal (Ryugo et al, 2006). This period of rapid cell growth is followed by a second, longer period during which cells slowly increase to adult size and synaptic maturation is completed (Larsen, 1984;Ryugo et al, 2006).…”

Section: Effect Of Chronic Electrical Stimulationmentioning

confidence: 99%

“…Changes in cell ultrastructure, including maturation of postsynaptic densities, intermembranous cisternae and cellular membranes, also occur during the first 30 days postnatal (Ryugo et al, 2006). This period of rapid cell growth is followed by a second, longer period during which cells slowly increase to adult size and synaptic maturation is completed (Larsen, 1984;Ryugo et al, 2006). Thus, electrical stimulation in our study probably was effective in increasing the size of the spherical cells in both neonatally and 30-day deafened cats, because maturation of the spherical cells was incomplete at the time stimulation was introduced.…”

Section: Effect Of Chronic Electrical Stimulationmentioning

confidence: 99%

Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats

et al. 2008

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This study examined the effects of deafness and intracochlear electrical stimulation on the anatomy of the cochlear nucleus (CN) after a brief period of normal auditory development early in life. Kittens were deafened by systemic ototoxic drug injections either as neonates or starting at postnatal day 30. Total CN volume, individual CN subdivision volumes, and cross-sectional areas of spherical cell somata in the anteroventral CN (AVCN) were compared in neonatally deafened and 30-day deafened groups at 8 weeks of age and in young adults after approximately 6 months of electrical stimulation initiated at 8 weeks of age. Both neonatal and early acquired hearing loss resulted in a reduction in CN volume as compared to normal hearing cats. Comparison of 8- and 32-week old groups indicated that the CN continued to grow in both deafened groups despite the absence of auditory input. Preserving normal auditory input for 30 days resulted in a significant increase in both total CN volume and cross-sectional areas of spherical cell somata, as compared to neonatally deafened animals. Restoring auditory input in these developing animals by unilateral intracochlear electrical stimulation did not elicit any difference in CN volume between the two sides, but resulted in 7% larger spherical cell size on the stimulated side. Overall, the brief period of normal auditory development and subsequent electrical stimulation maintained CN volume at 80% of normal and spherical cell size at 86% of normal ipsilateral to the implant as compared to 67% and 74%, respectively, in the neonatally deafened group.

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Postnatal development of a large auditory nerve terminal: The endbulb of Held in cats

Cited by 39 publications

References 60 publications

The role of spontaneous activity in development of the endbulb of Held synapse

The role of spontaneous activity in development of the endbulb of Held synapse

Morphological and physiological development of auditory synapses

Effects of age at onset of deafness and electrical stimulation on the developing cochlear nucleus in cats

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