Postnatal corticosteroid therapy in bronchopulmonary dysplasia - why animal studies disagree with clinical trials?
Anantha Harijith,
Thomas M. Raffay,
Rita M. Ryan
Abstract:The systematic review and meta-analysis of newborn animal models by Irene Lok et al. is the first to extensively summarize the literature regarding postnatal systemic corticosteroid use on lung development of newborn rodent models. The meta-analysis showed that the use of postnatal corticosteroids resulted in a reduction in body weight along with persistent alveolar simplification. The most frequently used corticosteroid was dexamethasone. Corticosteroids have been extensively used in clinical trials in preter… Show more
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